Proactive Approaches for a Wheelchair User in Pediatric Residency: A Case Study for Disability Inclusion.

Objective: Despite encountering many barriers to inclusion, people with disabilities are entering residency training in increasing numbers. However, the increase in representation among people with physical disabilities remains low and published case studies and accommodations processes for wheelchair users in pediatric residency are absent in the literature. To support the inclusion of residents with physical disabilities in residency, we outline a proactive approach to the accommodations process and inclusion of a resident with a physical disability in pediatric residency.

Modelling the effect of allopregnanolone on the resolution of spike-wave discharges.

Childhood absence epilepsy (CAE) is a paediatric generalized epilepsy disorder with a confounding feature of resolving in adolescence in a majority of cases. In this study, we modelled how the small-scale (synapse-level) effect of progesterone metabolite allopregnanolone induces a large-scale (network-level) effect on a thalamocortical circuit associated with this disorder. In particular, our goal was to understand the role of sex steroid hormones in the spontaneous remission of CAE.

SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL), a Snakemate workflow for rapid and bulk analysis of Illumina sequencing of SARS-CoV-2 genomes.

The incorporation of sequencing technologies in frontline and public health healthcare settings was vital in developing virus surveillance programs during the Coronavirus Disease 2019 (COVID-19) pandemic caused by transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, increased data acquisition poses challenges for both rapid and accurate analyses. To overcome these hurdles, we developed the SARS-CoV-2 Illumina GeNome Assembly Line (SIGNAL) for quick bulk analyses of Illumina short-read sequencing data.

A holistic physics-informed neural network solution for precise destruction of breast tumors using focused ultrasound on a realistic breast model.

This study presented a novel approach for the precise ablation of breast tumors using focused ultrasound (FUS), leveraging a physics-informed neural network (PINN) integrated with a realistic breast model. FUS has shown significant promise in treating breast tumors by effectively targeting and ablating cancerous tissue. This technique employs concentrated ultrasonic waves to generate intense heat, effectively destroying cancerous tissue.

Deep superpixel generation and clustering for weakly supervised segmentation of brain tumors in MR images.

Purpose: Training machine learning models to segment tumors and other anomalies in medical images is an important step for developing diagnostic tools but generally requires manually annotated ground truth segmentations, which necessitates significant time and resources. We aim to develop a pipeline that can be trained using readily accessible binary image-level classification labels, to effectively segment regions of interest without requiring ground truth annotations.

Methods: This work proposes the use of a deep superpixel generation model and a deep superpixel clustering model trained simultaneously to output weakly supervised brain tumor segmentations.

Analyzing the Life History of Caimans: The Growth Dynamics of Caiman latirostris From an Osteohistological Approach.

Skeletochronology and growth dynamics are intensively investigated in vertebrate osteohistology. These techniques are particularly important for interpreting the life history of long-lived species, such as crocodilians. To understand the longevity, growth dynamics, sexual maturity, and sexual dimorphism of caimans we studied an almost complete ontogenetic series of captive and wild specimens of Caiman latirostris from different localities of Argentina.

Perceived usability and acceptability of the My-Hip Fracture risk communication tool from the perspective of academic clinicians.

Objective: We evaluated the usability and acceptability of My-Hip Fracture (My-HF), a web application that assists providers in delivering individualized prognostic information to patients hospitalized for hip fracture (HF).

Methods: We observed a sample of 16 clinicians as they navigated My-HF. We then administered a structured questionnaire and conducted semi-structured interviews to explore participants' opinions about the app's content and the feasibility of incorporating the app into clinical workflows.

Structure-Activity Relationship Study of Splicing Modulators on Hsh155/SF3B1 through Chemical Synthesis and Yeast Genetics.

Meayamycins are synthetic analogs of the natural product FR901464 and exhibit potent anticancer activity against human cancers. They bind SF3B1 and PHF5A, components of the human spliceosome, and they alter pre-mRNA splicing. Detailed analysis of the active site led us to investigate a narrow pocket within the binding site that surrounds the α,β-unsaturated amide portion of meayamycin.

Child Abuse and Neglect and Obsessive-Compulsive Personality Traits: Effects of Attachment, Intolerance of Uncertainty, and Metacognition.

Child Abuse and Neglect (CAN) is extensively implicated as a risk factor preceding the development of Obsessive-Compulsive Personality Traits (OCPT). Nevertheless, the majority of individuals with a history of CAN do not go on to develop OCPT. To date, little research has investigated potential model networks that may help contribute to explaining why CAN sometimes leads to OCPT and not at other times.

Switchable Fluorescence of a Mechanical Stimulus-Responsive Au-P-S Complex.

The reaction of [(3-bdppmapy)(AuCl)] with NaHmna (3-bdppmapy = N,N'-bis-(diphenylphosphanylmethyl-3-aminopytidine, Hmna = 2-mercaptonicotinic acid)) resulted in a tetranuclear Au-P-S complex [(3-bdppmapy)(AuHmna)(AuCl)] () which emitted bright yellow fluorescence at 542 nm under 377 nm excitation (QY = 5.3%, = 0.83 ns).

Long-Term Survival of Canadian Liver Transplant Recipients Remains Stagnant- A Cohort Study on the Evolution of Cause-Specific Mortality.

Objective: Recent U.S. registry publications showed no improvement in long-term survival post-liver transplant in the last three decades.

Elucidating the Mechanism of Electrooxidative Allene Dioxygenation: Dual Role of Tetramethylpiperidine -Oxyl (TEMPO).

The cumulated π system of a nonsymmetric allene contains three distinct unsaturated carbons that imbue it with unique reactivity toward radicals as compared to its alkene and alkyne counterparts. Despite the synthetic potential of these versatile building blocks, electrochemical transformations of allenes have been historically underexplored. Myriad strategies for easy access to allenes, coupled with the resurgence of interest in sustainable oxidative transformations of hydrocarbons, prompted our efforts to conduct an in-depth investigation of a rare example of an electrochemical TEMPO-mediated allene dioxygenation.

Time-series data from a hybrid finite element Large Eddy Simulation of flow over a backward-facing step.

In previous work, a Large Eddy Simulation turbulence (LES) algorithm was developed for finite element-based computational fluid dynamics, using a hybrid continuous-discontinuous Galerkin scheme. The test case for this was a backward-facing step, which is a well-known example with published experimental results for validation. The results of this simulation were used to produce temporal statistics, such as averaged velocity and Reynolds stress profiles, and time-series data.

Chimeric aggregative multicellularity in absence of kin discrimination.

Aggregative multicellularity is a cooperative strategy employed by some microorganisms. Unlike clonal expansion within protected environments during multicellular eukaryotic development, an aggregation strategy introduces the potential for genetic conflicts and exploitation by cheaters, threatening the stability of the social system. , a soil-dwelling bacterium, employs aggregative multicellularity to form multicellular fruiting bodies that produce spores in response to starvation.

Use of Digital Health and Digital Therapeutics to Treat SUD in Criminal Justice Settings: a Review.

Purpose Of Review: The purpose of this review is to investigate the use of digital health technologies and/or digital therapeutics (DTx) products in the treatment of substance use disorders (SUDs) in the general population and among criminal justice-involved individuals.

Recent Findings: Despite an expanding evidence base, only three SUD DTxs have received federal regulatory approval. Across studies, DTx products have proven successful in engaging patients in SUD treatment and reducing healthcare costs and resource utilizations.

Becoming a person-centred facilitator of learning in a hospital setting: Findings from a participatory action-oriented study with hospital-based educators.

Aim: Investigate the experience of hospital-based educators becoming person-centred facilitators of learning.

Background: Hospital-based educators working with staff are not well-prepared for their role. No person-centred pedagogical approaches exist specifically for use in hospital settings.

BAMITA: Bayesian multiple imputation for tensor arrays.

Data increasingly take the form of a multi-way array, or tensor, in several biomedical domains. Such tensors are often incompletely observed. For example, we are motivated by longitudinal microbiome studies in which several timepoints are missing for several subjects.

The right to health for socioeconomically disadvantaged TB patients in South Korea: An AAAQ framework analysis.

Tuberculosis, a disease of poverty, continues to disproportionately affect socioeconomically disadvantaged populations worldwide. This is particularly concerning given the recent resurgence of TB following the COVID-19 pandemic. In South Korea, despite substantial socioeconomic development, TB remains a prominent problem, ranking as the leading infectious killer in the country.

PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress.

Uncontrolled degradation and collapse of stalled replication forks (RFs) are primary sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse remain to be fully elaborated. Here, we show that polynucleotide kinase-phosphatase (PNKP) localizes at stalled forks and protects stalled forks from excessive degradation. The loss of PNKP results in nucleolytic degradation of nascent DNA at stalled RFs.

sp. nov., a member of the isolated from badland surfaces in the Red Desert, Wyoming, USA.

A novel Gram-stain-positive, black-pigmented bacterium, designated as WL48A , was isolated from the surface of badland sedimentary rock in the Red Desert of Wyoming and characterized using a polyphasic taxonomic approach. Good growth occurred at 28-32 °C, pH 7-9, and NaCl less than 1% (w/v). Colonies, growing well on International Streptomyces Project media (ISP) 3 and ISP 7, were black and adhering to the agar.

Nitrogen doped carbon quantum dots: a multifaceted carbon nanomaterial that interferes in an amyloid-forming trajectory.

Carbon quantum dots (CQDs) are a versatile class of carbon-based nanomaterial frameworks that have previously been used as a diagnostic device, in sensing for environmental applications, in bioimaging, and for drug delivery systems. Their versatility stems from their ability to be chemically tailored functionalization to optimize properties for specific applications. In this study, we have synthesized lactic acid-derived nitrogen doped carbon quantum dots (LAdN-CQDs) and examined their ability to intervene in the conversion of soluble, monomeric hen egg-white lysozyme (HEWL) into mature fibrils.

Laser writing of metal-oxide doped graphene films for tunable sensor applications.

Flexible and wearable devices play a pivotal role in the realm of smart portable electronics due to their diverse applications in healthcare monitoring, soft robotics, human-machine interfaces, and artificial intelligence. Nonetheless, the extensive integration of intelligent wearable sensors into mass production faces challenges within a resource-limited environment, necessitating low-cost manufacturing, high reliability, stability, and multi-functionality. In this study, a cost-effective fiber laser direct writing method (fLDW) was illustrated to create highly responsive and robust flexible sensors.

repeat expansion creates the unstable folate-sensitive fragile site FRA9A.

The hyper-unstable Chr9p21 locus, harbouring the interferon gene cluster, oncogenes and , is linked to multiple diseases. (GGGGCC)n expansions (Exp) are associated with incompletely penetrant amyotrophic lateral sclerosis, frontotemporal dementia and autoimmune disorders. Exp patients display hyperactive cGAS-STING-linked interferon immune and DNA damage responses, but the source of immunostimulatory or damaged DNA is unknown.

Navigating challenges and cultivating connections: Faculty experiences teaching RN-BSN students.

Background: Success in completing an RN to BSN program largely depends on program quality, flexibility, and accessibility, as well as faculty ability to help students navigate several complex factors. Research specific to the RN-BSN student experience suggests that faculty teaching in RN-BSN programs must be respectful of diverse learners' needs, mindful to avoid bias and reduce stigma, and capable in creating equitable learning spaces. Faculty must also make content relevant to support immediate use by students in the workplace.