Association of Sympathovagal Imbalance with Increased Inflammation and Impaired Adaptive Immunity in Bladder Cancer Patients.

Stress responses can impact bladder cancer (BC) outcomes via immune-inflammatory pathway modulation. This study explores heart rate variability (HRV) associations with serum immune-inflammatory biomarkers, blood count inflammatory markers, and psychosocial self-report measures in patients versus healthy controls. The TREM-1 and TREM-2 expressions on peripheral blood monocytes were analysed via flow cytometry; serum inflammatory biomarkers by ELISA; HRV (5-min ECG) pre-tumour resection; blood counts by haematology analyser; and psychosocial factors by validated questionnaires.

Pleated colposuspension: Our modification of Burch colposuspension.

Introduction: Burch colposuspension is a standard treatment for stress urinary incontinence. However, it is associated with recurrence and urinary retention. We describe a modification of this technique to overcome these problems and evaluate the results in comparison with the standard procedure.

Ultrasound Characteristics of Patients with Urinary Stress Incontinence with or without Genital Prolapse.

Purpose: The study purpose was to evaluate the clinical and ultrasound characteristics of women with urinary stress incontinence (USI) with or without genital prolapse (GP).

Materials And Methods: A total of 268 patients who underwent ultrasound perineal evaluation were divided into two groups: isolated USI (n=132) and USIGP (n=136) with USI/GP stage I/II. The latter group was additionally divided into two subgroups: USIGP(A) (n=78) with USI/GP stage I and USIGP(B) (n=58) with USI/GP stage II.

Outcome Assessment of the Marshall Coughing Test during Cervix Reposition Maneuver in Women with Urinary Stress Incontinence with/without Genital Prolapse.

Objectives. Outcome assessment of the Marshall coughing test (MT) during cervix reposition maneuver (CRM) in women with urinary stress incontinence (USI) with/without genital prolapse (GP). Study Design.

Predictive values of the ultrasound parameters, CA-125 and risk of malignancy index in patients with ovarian cancer.

Backgrounds: Assessment of predictive values for CA-125, ultrasound features (US) and risk of malignancy index (RMI) in ovarian malignancy.

Material And Methods: 115 patients, divided into: 1) group-A (n = 41)--ovarian malignancy; group-B (n = 74)--benign ovarian tumor; 2) subgroup-CA(a) with low CA-125 (< 35 U/mL) (n = 64); subgroup-CA(b) with slightly elevated CA-125 (35-130 U/ml) (n = 26); subgroup-CA(c) with high CA-125 (> 130 U/ml) (n = 25).

Results: 1) patients of group-A were older (p < 0.

A new modification of the POPQ system--its effectiveness in the diagnosis of supravaginal elongation of the uterine cervix in cases with genital prolapse.

Background: The evaluation of a genital prolapse has to include the POPQ-pelvic organ position quantification as a descriptive system.

Objectives: Effectiveness of our modification of the POPQ in the diagnosis of supravaginal cervical elongation.

Methods: We evaluated our modification: Bal (midpoint of distance Aa/Va); Vas (most proximal point of anterior vaginal wall); Va (attachment of anterior vaginal wall to cervix); Vp (attachment of posterior vaginal wall to cervix); Vps (most proximal point of posterior vaginal wall); SU (attachment of sacrouterine ligaments to cervix); Bp1 (midpoint of distance Ap/Vp); as well as some level distances: (Vas-Va), (Vp-SU), (Vps-Vp), (Aa-Ba1) in 358 patients, divided into: group A-stage I/II prolapse; group B-stage I/II prolapse and cervical elongation; group C-stage III/IV prolapse; group D-stage III/IV prolapse and cervical elongation; group E-stage 0 prolapse and stress incontinence during Valsalva maneuver (Vm) and Pozzy maneuver (Pm).

Prooxidative/antioxidative homeostasis in heroin addiction and detoxification.

Background: Long-term heroin abuse is related to pathological changes in many organs mediated by oxidative stress (OS).

Objectives: Estimation of systemic OS and antioxidant capacity in heroin addiction and detoxification provides information about prooxidant/antioxidant homeostasis in heroin misuse and need for antioxidant supplementation.

Methods: OS was evaluated by the measurement of plasma reactive oxygen metabolites using spectrophotometric method and plasma lipid peroxidation by its end product--malondyaldehyd using Tiobarbituric Acid Reactions Substances method.

Combination of two anti-stress procedures: our original 4-corner deltoid-like vaginal suspension and suburethral duplication sec. Lazarevski in patients with genital prolapse.

Aim: The effectiveness of the combination of two anti-stress procedures: 1) our original 4-corner deltoid-like vaginal suspension; and 2) suburethral duplication sec. Lazarevski are analysed.

Study Design: 144 women, undergoing vaginal hysterectomy, combined with our original 4-corner deltoid-like vaginal suspension and suburethral duplication sec.

Vaginosacral colpopexy (VSC)--a new modification of the Mc Call operation using vaginosacral ligaments as autologous sliding grafts in posthysterectomy vault prolapse.

Objectives: The effect of a new modification of the Mc Call operation, vaginosacral colpopexy (VSC) was evaluated in the group of 32 patients.

Background: Due to our bad experience with transabdominal lumbosacral colpopexy, we tried to find out another solution.

Methods: VSC using the mobilized vaginosacral ligaments as sliding grafts (two sutures through the vaginosacral ligaments and posterior vaginal wall and the third suture through the uterosacral ligaments) for vault prolapse was performed in the group of 32 patients.

Benefit and safety of 28-day transdermal estrogen regimen during vaginal hysterectomy (a controlled trial).

Objectives: Assessment of benefit and safety of 28-day transdermal 17-beta estradiol regimen during vaginal hysterectomy.

Methods: Two-hundred and sixty-nine postmenopausal women, undergoing vaginal hysterectomy were divided into: transdermal estrogen hormone replacement therapy (TEHRT) group (n=119) with 28-day transdermal 17-beta estradiol 50 mg/day, 14 days before and after operation; and vaginal estrogen hormone replacement therapy (VEHRT) group (n=150) with 14-day preoperative vaginal conjugated estrogen 0.625 mg/day.

Structural aspects of flavonoids as trypsin inhibitors.

In the search for new proteinase inhibitors we have focused on the screening and Computer Assisted Drug Design (CADD) studies of polyphenolic compounds. In this paper we report CADD of flavonoles and flavones as trypsin inhibitors concomitant by the screening results. 5,7-Dihydroxy flavonoid have been found to be a perspective trypsin/trypsin-like-enzyme inhibitor.