Antimicrobial resistance pattern of avian pathogenic with detection of extended-spectrum β-lactamase-producing isolates in broilers in east Algeria.

Background And Aim: Avian pathogenic (APEC) is the causative agent of colibacillosis, one of the most prevalent bacterial diseases responsible for significant economic losses in the poultry industry worldwide. This study aimed to assess the antimicrobial resistance (AMR) patterns of APEC isolates recovered from poultry in east Algeria and estimate the prevalence of extended-spectrum β-lactamase (ESBL)-producing isolates.

Materials And Methods: In the slaughterhouse of Batna City (Algeria), livers indicating colibacillosis were sampled from 204 suspected carcasses with growth retardation and generalized congestion.

Evaluation of the Antiparasitic and Antifungal Activities of Synthetic Piperlongumine-Type Cinnamide Derivatives: Booster Effect by Halogen Substituents.

A series of synthetic N-acylpyrrolidone and -piperidone derivatives of the natural alkaloid piperlongumine were prepared and tested for their activities against Leishmania major and Toxoplasma gondii parasites. Replacement of one of the aryl meta-methoxy groups by halogens such as chlorine, bromine and iodine led to distinctly increased antiparasitic activities. For instance, the new bromo- and iodo-substituted compounds 3 b/c and 4 b/c showed strong activity against L.

Synthesis, characterization, anticancer activity and molecular docking of metal complexes bearing a new Schiff base ligand.

2-(()-((4-((()-4-Nitrobenzylidene)amino)phenyl)imino)methyl)naphthalen-1-ol, was synthesised followed by metalation with Fe(III), Co(III), Cu(II), Zn(II) and Ni(II) metals. The compounds were characterised by different methods CHN, AAS, IR, NMR, XRD, TGA and UV-Vis. The results reveal that the ligand has bidentate behavior, and it is bound with metals by a coordination bond through both the nitrogen atom of the azomethine group and the oxygen atom, this provided an octahedral geometry.

Deep Learning Solution for Quantification of Fluorescence Particles on a Membrane.

The detection and quantification of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus particles in ambient waters using a membrane-based in-gel loop-mediated isothermal amplification (mgLAMP) method can play an important role in large-scale environmental surveillance for early warning of potential outbreaks. However, counting particles or cells in fluorescence microscopy is an expensive, time-consuming, and tedious task that only highly trained technicians and researchers can perform. Although such objects are generally easy to identify, manually annotating cells is occasionally prone to fatigue errors and arbitrariness due to the operator's interpretation of borderline cases.

Deep-active-learning approach towards accurate right ventricular segmentation using a two-level uncertainty estimation.

The Right Ventricle (RV) is currently recognised to be a significant and important prognostic factor for various pathologies. Its assessment is made possible using Magnetic Resonance Imaging (CMRI) short-axis slices. Yet, due to the challenging issues of this cavity, radiologists still perform its delineation manually, which is tedious, laborious, and time-consuming.

Biosynthesis MgO and ZnO nanoparticles using chitosan extracted from Pimelia Payraudi Latreille for antibacterial applications.

Chitosan (CS) is one of the most abundant biopolymers in nature with superior properties such as biocompatibility, biodegradability, lack of toxicity, antimicrobial activity, acceleration of wound healing, and stimulation of the immune system. In this study, chitosan was extracted from the exoskeletons of beetles (Pimelia payraudi latreille) and then used for the biosynthesis of highly pure MgO NPs and ZnO NPs by a facile greener route. The extracted chitosan exhibited excellent physicochemical properties, including high extraction yield (39%), high degree of deacetylation (90%), low ash content (1%), high fat-binding capacity (366%), and unusual crystallinity index (51%).

Efficacy of endemic Algerian essential oils against single and mixed biofilms of Candida albicans and Candida glabrata.

Objectives: This study investigated the in vitro effect of Origanum glandulosum, Ammoides verticillata, and Saccocalyx satureioides essential oils against planktonic cells and biofilms formed by single and mixed species of Candida albicans and Candida glabrata oral isolates. The effect of the essential oils in combination with amphotericin B on planktonic cells was also studied.

Design: The antifungal susceptibility of planktonic cells was evaluated by disc diffusion and broth microdilution methods.

Modern vision for critical flow in an egg-shaped section (Part II).

The main aim of this research was to examine the simultaneous effects of all flow parameters on the critical regime occurrence frequency in an egg-shaped conduit. Furthermore, one may first study the impacts of the conduit's generator diameter, then the influence of the generator diameter/longitudinal slope, and finally the effect of all parameters: the generator diameter, longitudinal slope, roughness and viscosity. It has been concluded that all these parameters, combined, have limit values that can generate a single critical state from which a diagram can be drawn showing different states of the critical flow that can be observed.

Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study.

The effectiveness of curcumin in preventing and treating collagen-induced inflammatory arthritis (CIA) in rats and oxidative stress in rats was investigated. We investigated curcumin's curative and preventive effects on paw edema, arthritic size, body weight, and radiologic and histological joint abnormalities. It has been shown that curcumin may dramatically lower the risk of developing arthritis.

Study on correlation between shadow patterns and human behaviour in hot, arid cities: a case study of Biskra, Algeria.

Although the thermal comfort benefits of shade in warm areas are well known, empirical work on the link between public space use and shade pattern from hot, arid cities remain poorly investigated. The aim of the present study is to investigate the correlation between shadow pattern, outdoor thermal comfort and human behaviour, according to the intensity of public space use by urban dwellers. This work was conducted in an urban area in Biskra City (Algeria), characterized by a hot climate, with an average high temperature 40.

The effect of spices L., L., L., and their combinations on growth performance, carcass trait, and hematobiochemical parameters in broiler chicken.

Background And Aim: The incorporation of herbs and species has been shown to enrich the food with antioxidants and bioactive antimicrobial compounds, thereby preserving the safety and productivity of broiler chicken production. This study aimed to determine the effects of three phytogenic feed additives (PHT) on certain zootechnical and hematobiochemical parameters in broiler chickens. .

Particle Swarm Optimization and Two-Way Fixed-Effects Analysis of Variance for Efficient Brain Tumor Segmentation.

Segmentation of brain tumor images, to refine the detection and understanding of abnormal masses in the brain, is an important research topic in medical imaging. This paper proposes a new segmentation method, consisting of three main steps, to detect brain lesions using magnetic resonance imaging (MRI). In the first step, the parts of the image delineating the skull bone are removed, to exclude insignificant data.

Investigation of [H]diazepam derivatives as allosteric modulators of GABAA receptor αβγ subtypes: combination of molecular docking/dynamic simulations, pharmacokinetics/drug-likeness prediction, and QSAR analysis.

Unlabelled: In this paper, a data set of [H] diazepam derivatives was analyzed using various computational methods: molecular docking/dynamic simulations, and QSAR analysis. The main aims of these studies are to understand the binding mechanisms by which benzodiazepines allosterically modulate GABA receptor αβγ subtypes, from inducing neuronal inhibition at lower doses to the anesthetic effect at higher doses, and also, to define the structural requirements that contribute to improving the response of GABA/αβγ receptor to benzodiazepine drugs. The results of the molecular docking study allowed selecting Ro12-6377 and proflazepam as the best modulators for the four binding sites simultaneously.

Phenolic Characterization Using cLC-DAD Analysis and Evaluation of In Vitro and In Vivo Pharmacological Activities of Forssk.

The perennial aromatic plant Forssk (Rutaceae) has been traditionally used by Mediterranean peoples as folk medicine against several types of disease to treat diverse illness. The objective of this work is to evaluate the in vitro and in vivo pharmacological activities of the aqueous (RAE) and methanolic (MeOH) 80% (RME) extracts of Algerian aerial parts. Antioxidant potential, neuro-protective and anti-arthritic activities were investigated in vitro using six antioxidant approaches and by determining acetyl-cholinesterase and bovine albumin denaturation inhibitory capacities, respectively.

Enhanced activity of hyperthermostable Pyrococcus horikoshii endoglucanase in superbase ionic liquids.

Objectives: Ionic liquids (ILs) that dissolve biomass are harmful to the enzymes that degrade lignocellulose. Enzyme hyperthermostability promotes a tolerance to ILs. Therefore, the limits of hyperthemophilic Pyrococcus horikoschii endoglucanase (PhEG) to tolerate 11 superbase ILs were explored.

Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies.

Unlabelled: A new and suitable multicomponent one-pot reaction was developed for the synthesis of 2-amino-3-cyanopyridine derivatives.

Background: This synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using enaminones as key precursors under solvent-free conditions.

Methods: A range of spectroscopic techniques was used to determine and confirm the chemical structures (FTIR, H NMR, C NMR).

A Preliminary Survey of Olive Grove in Biskra (Southeast Algeria) Reveals a High Diversity of Thrips and New Records.

This study was conducted to determine Thysanoptera species composition associated with olive trees, fruit injury, fluctuations in the abundance of the most phytophagous species relative to the phenological stages of the olive tree, and the temporal variations in the species in relation to environmental variations in Biskra province between 2018 and 2020. The olive orchard chosen for this study is located at the Experimental Station of the Technical Institute for the Development of Saharan Agriculture (ITDAS) in El Outaya (Biskra, a Saharan region of Algeria). Five trees were sampled each week, and thrips were collected by shaking 20 twigs (4 twigs per tree).

Roadside Unit Deployment in Internet of Vehicles Systems: A Survey.

In recent years, the network technology known as Internet of Vehicles (IoV) has been developed to improve road safety and vehicle security, with the goal of servicing the digital demands of car drivers and passengers. However, the highly dynamical network topology that characterizes these networks, and which often leads to discontinuous transmissions, is one of the most significant challenges of IoV. To address this issue, IoV infrastructure-based components known as roadside units (RSU) are designed to play a critical role by providing continuous transmission coverage and permanent connectivity.

IoMT-fog-cloud based architecture for Covid-19 detection.

Limitations Of Available Literature: Nowadays, coronavirus disease 2019 (COVID-19) is the world-wide pandemic due to its mutation over time. Several works done for covid-19 detection using different techniques however, the use of small datasets and the lack of validation tests still limit their works. Also, they depend only on the increasing the accuracy and the precision of the model without giving attention to their complexity which is one of the main conditions in the healthcare application.

Sand Flies (Diptera: Psychodidae): Fauna and Ecology in the Northeast of Algeria.

Sand flies (Diptera: Psychodidae) transmit several Leishmania (Kinetoplastida: Trypanosomatidae) species, which cause leishmaniasis, a significant public health concern in Algeria. We compared sand fly species abundance and composition among different biotopes (urban, peri-urban, rural areas), bioclimatic zones (humid, sub-humid, semi-arid), and elevation ranges. We also used the additive partitioning of beta diversity to test whether the variation in sand fly composition among biotopes, bioclimatic zones, and elevation ranges is due to species turnover or community subsetting.

Nephroprotective Efficacy of Selenium and Zinc Against Potassium Dichromate-Induced Renal Toxicity in Pregnant Wistar Albino Rats.

Hexavalent chromium (CrVI) compounds are potent toxicants commonly used in numerous industries. Thus, potential toxic effects and health hazards are of high relevance. Selenium (Se) and zinc (Zn) are known for their antioxidant and chemoprotective properties.