1,356 results match your criteria: "University "Alexandru Ioan Cuza".[Affiliation]"

This study aimed to investigate the relationship between autobiographical memory, exposure to traumatic events, and quality of life, in a group of elderly people. The study was conducted using a sample of 362 participants ( = 68.35, = 6.

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Our study aims to identify if the deviation from a balanced time perspective (DBTP) is a predictor of the quality of life among older adults. We also investigated whether awareness of aging moderated and death anxiety mediated the relationship between DBTP and quality of life. A sample of 436 participants was involved in the study ( = 68.

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Cooperative photoinduced switching of molecular materials at the nanoscale is still in its infancy. Strongly cooperative spin-crossover nanomaterials are arguably the best prototypes of photomagnetic and volume-changing materials that can be manipulated by short pulses of light. Open questions remain regarding their non-equilibrium dynamics upon light excitation and the role of cooperative elastic interactions in nanoscale systems that are characterized by large surface/volume ratios.

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This study aimed to isolate Streptomyces sp. from Moroccan terrestrial ecosystems and identify bioactive compounds through GC-MS analysis. Antimicrobial activity was assessed against various pathogenic microorganisms including Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922 and Candida albicans ATCC 60193, and multi-drug resistant strains comprising Listeria monocytogenes, Klebsiella pneumoniae 19K 929, Proteus sp.

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Environmental concerns have consistently been a focal point for the scientific community. Pollution is a critical ecological issue that poses significant threats to human health and agricultural production. Contamination with heavy metals and pesticides is a considerable concern, a threat to the environment, and warrants special attention.

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A Coarse-Grained Molecular Dynamics Perspective on the Release of 5-Fluorouracil from Liposomes.

Mol Pharm

December 2024

Department of Bioinformatics, TRANSCEND Research Center, Regional Institute of Oncology, 2-4 General Henri Mathias Berthelot, Street, Iaşi 700483, Romania.

Liposomes, small bilayer phospholipid-containing vesicles, are frequently used to ensure slow drug release for a prolonged and improved therapeutic effect. Nevertheless, current findings on the membrane affinity and permeability of the anticancer agent 5-fluorouracil (5-FU) are confounding, which leads to a lack of a clear understanding of how lipid composition impacts the distribution of 5-FU within liposomal structures and its delivery. In the current work, we report a comprehensive coarse-grained molecular dynamics (CGMD) investigation on the influence of cholesterol (CHOL) and the cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) on the partitioning of 5-FU in 1,2-dipalmitoyl--glycero-3-phosphocholine (DPPC) double-bilayer systems, as well as its in vitro release from liposomes with identical lipid compositions.

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Explanatory factors of digital citizenship among university students. A cross-national dataset.

Data Brief

December 2024

Educational Sciences Department, Faculty of Psychology and Educational Sciences, Alexandru Ioan Cuza University of Iași, Iasi, Romania.

The present research explores a set of explanatory factors of digital citizenship in university students on a cross-national sample. The data were collected from 501 university students aged 19-23 years old, from two public universities in Romania ( = 350) and Italy ( = 151). Information was gathered from one university in each country by using an online survey form.

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Article Synopsis
  • Preparative chromatographic enantioseparation is the top method for isolating pure enantiomers during the early development of new drugs.
  • Supercritical fluid chromatography was chosen for this process due to its advantages over traditional liquid chromatography.
  • A total of 10 mg of each enantiomer of a new anti-inflammatory compound was successfully isolated, although some peak distortion occurred during testing, likely caused by the method of injection used.
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There is convincing evidence that the learning environments digitalization of tools and equipment ultimately results in the speed and depth learning involvement of academia members, by raising attainment of each of the digital learning experiences. The majority of the research that was conducted on the topic of enhancing the digital skills of learners, which would ultimately lead to an increase in their active engagement, was conducted on students in primary and secondary education, leaving members of higher education outside of the scope of the study. Given the uninterrupted search for academic performance and innovation, the current research considers the technological changes that lead to the transformation of the traditional academic learning environments as previously known.

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A search for the exclusive hadronic decays W^{±}→π^{±}γ, W^{±}→K^{±}γ, and W^{±}→ρ^{±}γ is performed using up to 140  fb^{-1} of proton-proton collisions recorded with the ATLAS detector at a center-of-mass energy of sqrt[s]=13  TeV. If observed, these rare processes would provide a unique test bench for the quantum chromodynamics factorization formalism used to calculate cross sections at colliders. Additionally, at future colliders, these decays could offer a new way to measure the W boson mass through fully reconstructed decay products.

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Article Synopsis
  • - The ATLAS experiment at the LHC conducted a search for long-lived particles (LLPs) using a large dataset (140 fb^{-1}) from proton-proton collisions at 13 TeV, focusing on LLPs with masses from 5 to 55 GeV that decay within the inner detector.
  • - The study considered scenarios where LLPs are produced from exotic Higgs boson decays and models involving axionlike particles (ALPs).
  • - No significant findings above expected background levels were detected, leading to the establishment of upper limits on various production rates involving the Higgs boson and the top quark related to LLPs and ALPs.
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Review of the Palaearctic species of Bouček, 1956 (Chalcidoidea, Pteromalidae), with descriptions of the eight new species.

Zookeys

October 2024

The Science Museum of Natural Enemies, Geochang 50147, Republic of Korea The Science Museum of Natural Enemies Geochang Republic of Korea.

Palaearctic species of the genus Bouček, 1956 are reviewed. Twelve Palaearctic species are recognized based on females, of which eight new species are described: Tselikh, Lee & Ku, (Republic of Korea), Tselikh, Lee & Ku, (Republic of Korea), Tselikh, Haas & Ku, (Republic of Korea, Sweden), Tselikh, Lee & Ku, (Republic of Korea), Tselikh, Lee & Ku, (Republic of Korea), Tselikh, Lee & Ku, (Republic of Korea), Tselikh, Haas & Ku, (Germany, Japan, Sweden), and Tselikh, Haas & Ku, (Russia, Republic of Korea, Sweden). The female of Bouček, 1956 is described for the first time.

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Methicillin-resistant (MRSA) is considered the main cause of nosocomial and community-associated infections. Because of antimicrobial resistance, MRSA infections are difficult or impossible to treat, leading to high mortality rates and significant economic and societal costs. In view of the MRSA challenge to public health all over the world, the identification of new and effective anti-MRSA agents is a high medical priority.

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Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer.

Int J Mol Sci

October 2024

Biochemistry & Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY 13699-5810, USA.

Environmental exposure to a mixture of chemical xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis and the development of breast cancer (BC). Before anything else, we are what we eat. In this review, we highlight both "the good" and "the bad" sides of the daily human diet and dietary patterns that could influence BC risk (BCR) and incidence.

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This study aimed to explore the antioxidant potential of the ethyl acetate extract of Streptomyces coeruleofuscus SCJ strain, along with its inhibitory effects on the triple-negative human breast carcinoma cell line (MDA-MB-468). The ethyl acetate extract's total phenolic and flavonoid contents were quantified, and its antioxidant activity was investigated using DPPH (1,1-Diphenyl-2-picrylhydrazyl), ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), and FRAP (Ferric Reducing Antioxidant Power) assays. Furthermore, the cytotoxic effect of the organic extract from Streptomyces coeruleofuscus SCJ on MDA-MB-468 cancer cells was assessed via the crystal violet assay.

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This paper assesses the National Recovery and Resilience Plans (NRRPs) of EU member states and regions to uncover commonalities and differences between green and digital transitions, focusing on the role of institutions, among additional socio-economic drivers, in modeling them. To that end, relevant indicators have been assembled, and several econometric models have been developed and tested to evaluate institutional performance in relation to green and digital transformations. The study reveals discrepancies in the two explored transition fields and highlights the power of institutional factors in boosting them.

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Article Synopsis
  • The study investigates the associated production of Higgs and W bosons, focusing on how the relative signs of the Higgs couplings to W and Z bosons impact the process.
  • Two specific searches were conducted using large amounts of collision data from the LHC to analyze different coupling scenarios: one for opposite-sign couplings and another for same-sign (standard model-like) couplings.
  • The results significantly exclude the opposite-sign coupling hypothesis and set a strict upper limit on the production rate of this process compared to standard model predictions.
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The past performance and the capital structure of the companies that are involved in mergers and acquisition (M&As) are considered into the analysis of the circular causality relationship between financial performance and market value. Considering two models, one for value relevance and one for accounting conservatism, this paper aims to analyze if the capital market influences the accounting practices of a target company or that the accounting figures influence the capital market. The analyzed sample used in the study is represented by the target companies involved in M&As which took place in the European Union Enlarged in 2017-2018.

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Tumor-on-chip platforms for breast cancer continuum concept modeling.

Front Bioeng Biotechnol

October 2024

Biochemistry & Proteomics Laboratories, Department of Chemistry and Biochemistry, Clarkson University, Potsdam, NY, United States.

Our previous article entitled "Proteomics and its applications in breast cancer", proposed a Breast Cancer Continuum Concept (BCCC), including a Breast Cancer Cell Continuum Concept as well as a Breast Cancer Proteomic Continuum Concept. Breast cancer-on-chip (BCoC), breast cancer liquid biopsy-on-chip (BCLBoC), and breast cancer metastasis-on-chip (BCMoC) models successfully recapitulate and reproduce the principal mechanisms and events involved in BCCC. Thus, BCoC, BCLBoC, and BCMoC platforms allow for multiple cell lines co-cultivation to reproduce BC hallmark features, recapitulating cell proliferation, cell-to-cell communication, BC cell-stromal crosstalk and stromal activation, effects of local microenvironmental conditions on BC progression, invasion/epithelial-mesenchymal transition (EMT)/migration, intravasation, dissemination through blood and lymphatic circulation, extravasation, distant tissues colonization, and immune escape of cancer cells.

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Conventional passive packaging plays a crucial role in food manufacturing by protecting foods from various external influences. Most packaging materials are polymer-based plastics derived from fossil carbon sources, which are favored for their versatility, aesthetic appeal, and cost-effectiveness. However, the extensive use of these materials poses significant environmental challenges due to their fossil-based origins and persistence in the environment.

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Article Synopsis
  • Growing interest in cognitive dysfunction related to Alzheimer's disease (AD) highlights the need for effective therapies, as current treatments have limitations.
  • Flavonoids have shown promise due to their antioxidative, anti-inflammatory, and anti-amyloidogenic properties, which could help combat AD symptoms.
  • In this study, researchers tested three flavonoids in zebrafish to assess their potential to improve memory, reduce anxiety, and lower oxidative stress, finding that these compounds positively influence gene expression related to neuroprotection and synaptic function.
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Six polysaccharide-based chiral stationary phases were screened to separate the enantiomers of six chloro-containing derivatives and one derivative bearing electron donating mesomeric substituents, chosen for comparison. These compounds are expected to be P2X7 receptor antagonists with potential anti-inflammatory activity. The study was carried out with four different mobile phases composed of n-heptane and ethanol or isopropanol.

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Investigating the Impact of Nutrition and Oxidative Stress on Attention Deficit Hyperactivity Disorder.

Nutrients

September 2024

Department of Gastroenterology, "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, University Street No. 16, 700115 Iași, Romania.

Attention deficit hyperactivity disorder (ADHD) is the most common childhood-onset neurodevelopmental disorder, characterized by difficulty maintaining attention, impulsivity, and hyperactivity. While the cause of this disorder is still unclear, recent studies have stated that heredity is important in the development of ADHD. This is linked to a few comorbidities, including depression, criminal behavior, and anxiety.

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Rapid Tryptophan Assay as a Screening Procedure for Quality Protein Maize.

Molecules

September 2024

Integrated Centre of Environmental Science Studies in the North East Region-CERNESIM Centre, Institute of Interdisciplinary Research, Alexandru Ioan Cuza University of Iasi, 11 Carol I, 700506 Iasi, Romania.

Tryptophan is an essential amino acid deficient in cereals, especially maize. However, maize ( L.) is the main source of protein in some developing countries in Africa and Latin America.

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