[Rare intracranial plasmacytoma manifestations. Case reports and review of the literature in diffuse plasmocytoma, in primary solitary extramedullary plasmacytoma in in primary solitary osseous plasmacytoma].

Plasmacytomas can be divided into multiple, solitary osseous and solitary extraosseous/extramedullary plasmacytomas. Intracranial plasmacytomas of the dura, leptomeninx and cerebrum are well known from the literature. They are manifestations of multiple myeloma, intracranial extramedullary plasmacytoma or metastatic disease of extramedullary plasmacytoma in distant locations.

Serum concentrations of thyroid hormones in patients with nonseasonal affective disorders during treatment with bright and dim light.

Serum concentrations of thyroxine (T4), triiodothyronine (T3), and thyrotropine were measured in 34 patients with nonseasonal affective disorders before and after 1 week of light treatment. Nineteen of these patients received bright white light (2500 lx) and 15 dim red light (50 lx) for 2 hours daily in the mornings over a 1-week period. Slight but significant reductions in the rating scores for the depressive symptomatology were found for both the bright-and dim-light groups, but there were no significant differences between the two groups.

The reproducibility and validity of furcation measurements using a pressure-calibrated probe.

The furcation involvement of 100 molars in 25 patients suffering from moderate to advanced periodontitis was investigated. The horizontal probing attachment level (PAL-H) within the furcations was assessed 2x within 2 weeks using the pressure-calibrated (0.25 N) flexible plastic universal explorer version of the TPS probe (TPS).

[Renal artery dilatation in renovascular hypertension. Acute and long-term outcome in a large patient sample].

Background: Renal angioplasty is an established therapy for treatment of renovascular hypertension. This study was performed to evaluate short- and long-term outcome of this procedure up until 3 years afterwards.

Patients And Methods: Altogether, 111 renal artery stenosis in 92 patients were dilated.

Structural investigations on small RNA molecules using different force field methods.

The structures of two kinds of small RNA hairpin loops were investigated. As an example of four-membered loops the family of GNNA-loops was chosen, and the influence of a variation of the two middle bases on the rather uncommon G-A base pair was examined. Comparison of the resulting structures showed surprisingly little dependence on the sequence for the overall structure and for the G-A base pair geometry.

Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor.

The physiologically active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Parallel to the increase in cell-cell communication, we observed a VDR-dependent increase in connexin43 protein and connexin43 mRNA levels.

[Possible errors in diagnosis of left atrial thrombosis in transesophageal echocardiography].

The detection of thrombi in the left atrium and left atrial appendage by transesophageal echocardiography has significant diagnostic and therapeutic value. However, it requires high method accuracy in routine evaluation. In order to record the percentage of false positive findings, a reevaluation was performed by two experienced examiners using the video recordings of 51 patients, in whom a thrombus has been diagnosed during the routine evaluation.

[Value of immunohistochemical determination of receptors, tissue proteases, tumor suppressor proteins and proliferation markers as prognostic indicators in primary breast carcinoma].

Objective: We tested whether immunohistochemical detection of oestrogen and progesterone receptor (ER, PR), the oestrogen-dependent protein pS2, the growth hormone receptors p 185neu and EGF-R, the tumour suppressor protein p53, the tissue proteases Cathepsin D and Urokinase, and the proliferation marker PCNA are of prognostic relevance in breast cancer patients.

Methods: Expression of the proteins listed above was evaluated in formalin-fixed and paraffin-embedded sections of 311 primary breast cancer specimens using modified Avidin-Biotin-Complex methods. Results were correlated to clinical and morphological parameters (age, menopausal status, nodal status, tumour size, tumour grade), and clinical course of disease (complete follow-up in 301 women, median observation time 62 months) utilising univariate and multivariate statistical analyses.

[MRI-controlled intervention in suspected lesions of the breast].

Purpose: To evaluate two different systems for magnetic resonance (MR) imaging-guided breast interventions.

Materials And Methods: 41 patients with 41 lesions detected exclusively with contrast-enhanced MR imaging underwent 68 interventional procedures (27 needle biopsies and 41 preoperative wire localisations) with two different systems. An add-on device for surface coils was used in 39 cases, and a dedicated single breast biopsy coil was used in 29.

[Type II diabetic patients in general practice. A regional questionnaire survey--analysis and consequences].

In the offices of 26 general practitioners in Upper Franconia, Germany, a complete survey of all type II diabetics was carried out. A total of 2,180 type II diabetics were analyzed in terms of age, sex and treatment with diet alone, tablets, or insulin. On average, each office is looking after 7.

Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes.

The effect of zinc ions on carbohydrate metabolism and intracellular Zn2+ was studied in hepatocytes from fed rats. The addition of ZnCl2 to the medium led to an almost 3-fold increase in lactate production and an increase in net glucose production of about 50%. Half-maximal rates occurred at about 40 microM ZnCl2.

Previously unknown aldehydic lipid peroxidation compounds of arachidonic acid.

Arachidonic acid was oxidized by iron ascorbate. Samples were withdrawn in time intervals. The aldehydic oxidation products were trapped by preparation of pentafluorbenzyloximes.

[Legal definition of the accident concept in social accident insurance].

For the first time, the "Gesetz zur Einordnung des Rechts der gesetzlichen Unfallversicherung in das Sozialgesetzbuch (Unfallversicherungs-Einordnungsgesetz UVEG)" from August 7, 1996, defines the term "accident" in the social accident insurance, as expressed since January 1, 1997, in 8 I Sozialgesetzbuch (SGB) VII. This legal definition widely corresponds to the definition in the private accident insurance as well as to the previous interpretation known from the literature and the jurisdiction.

[The 16th October 1846 and its outcome].

Morton's first successful public demonstration of ether anaesthesia for a surgical operation, performed on October 16, 1846 in Boston/Massachusetts, had far-reaching consequences. The first effect was the surprisingly fast propagation of the new way of preventing pain to nearly all parts of the globe. Anaesthesia made it possible to perform operations previously considered impossible under conditions now acceptable for the patient.

MR imaging of residual tumor tissue after transsphenoidal surgery of hormone-inactive pituitary macroadenomas: a prospective study.

22 patients were examined by magnetic resonance (MR) imaging before and after transsphenoidal surgery of hormone-inactive pituitary macroadenomas to evaluate for tumor removal. MR imaging was performed without and with gadolinium-DTPA before the operation and 3 months after. In all cases a suprasellar tumor extension was found preoperatively, in 9 cases with an additional parasellar, in 2 cases with an additional retrosellar extension (average diameter 2.

Proliferation parameters for pituitary adenomas.

In this review, the value of assessing proliferation parameters in surgically resected pituitary tumour tissue is analyzed. Histological examination of basal dura biopsies identifies invasive growth even when intraoperatively not apparent to the surgeon. Determination of DNA-polymerase activity, Ki-67 immunohistochemistry and DNA-flow-cytometry shows a clear difference in the proliferative potential of enclosed and invasive pituitary adenomas.

[Causal "cancer personality" attribution--an expression of maladaptive coping with illness?].

In psycho-oncology, the concept of a "cancer-prone personality" has gained some attention. This notion means that persons who try to stay pseudo-normal in spite of severe life stress, suppress negative emotions, particularly anger, and sacrifice themselves for other people without uttering any personal demands, are at a high risk to develop cancer. However, it has been demonstrated by previous research that features of the cancer-prone personality could only be found if the ill person was convinced to suffer from cancer, irrespective of what the factual diagnosis was.

[Dyssocial identity disorder (double identity) in psychopathology and poetry].

Identity dissociation signifies: there seem to exist two identities in one personality that take turns-apparently without knowing about each other. Descriptions of this rare state are often spectacular. As scientifically proven they depend on culturally specific conditions and iatrogeneous influences.

[Depressive symptoms and syndromes in adolescents].

The present study examined the frequency of self-reported depressive symptoms in high school students aged 11 to 19 years using the Revised Ontario Child Health Study Scales. A high percentage of subjects occasionally experienced some types of depressive symptoms in the last six months. Three levels of diagnostic certainty were generated by varying the severity of depressive symptoms.

Changes in DNA supertwist as a response of Bacillus subtilis towards different kinds of stress.

We have investigated the change in DNA supercoiling in Bacillus subtilis after exposure to different kinds of stress. No or only minor effects are induced by solvents. Anaerobiosis and heat shock result in plasmids which are less negatively supercoiled.

[Compliance with psychiatric legal ordinance section 63 STGB. Legal principles--current status--treatment concepts--perspectives].

According to German law, delinquents who are considered either not fully responsible or not responsible at all for their actions because of a mental disorder receive no punishment or a lesser degree of punishment in criminal trials. They may, however, be sentenced to psychiatric treatment either in a psychiatric hospital or in an addiction centre, if the risk of them committing such offenses in the future is considered to be high. This article reviews the current situation of mentally ill offenders in hospitals and explores possible developments in forensic psychiatry.