Pharmacokinetics of ofloxacin in patients on haemodialysis treatment.

Serum concentrations and pharmacokinetic parameters of ofloxacin were measured in 10 patients on haemodialysis treatment. Serum half-life during the interdialytic interval was 48 hours, and during haemodialysis treatment 10 hours. The decrease in serum concentrations during a 4-hour haemodialysis was 25%.

Nitro-tyrosine as promoter of free radical damage in a DNA model system.

Nitro-tyrosine considerably promotes the degradation of DNA, when incubated with Cu2+ and ascorbate in oxygenated aqueous solution. This deleterious process requires oxygen and can be inhibited with catalase, indicating that H2O2 is involved, via the reduction of oxygen. Menadione and 2,4,6-trinitrobenzenesulfonate, known to catalyze particularly fast such reduction of oxygen, were only slightly more active than nitro-tyrosine.

[Investigations on the incompatibility in theCulex pipiens-complex].

In crosses between populations of the mosquitoCulex pipiens of different geographical origin three crossing types have been found (1) crosses with normal offspring (2) crosses with reduced offspring and (3) crosses that show almost total incompatibility. In the case of incompatible crosses 99.9% of the embryos are lethal and only about 0.

[Regional shifts in the vertebral column of inbred mice treated with X-rays or FCdR].

In three inbred-strains of mice (C57 BL/6, C57 BL/10 and C57 BL/Ks) 5-fluoro2'-deoxycytidine (FCdR) and X-rays have been applied at several stages of pregnancy. The shiftings of the regions of the vertebral column in the offspring have been examined. 1.