An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive.

Background: Oxidative stress is strongly linked to neurodegeneration through the activation of c-Abl kinase, which arrests α-synuclein proteolysis by interacting with parkin interacting substrate (PARIS) and aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2). This activation, triggered by ataxia-telangiectasia mutated (ATM) kinase, leads to dopaminergic neuron loss and α-synuclein aggregation, a critical pathophysiological aspect of Parkinson's disease (PD). To halt PD progression, pharmacological inhibition of c-Abl kinase is essential.

Navigating the nano-world future: Harnessing cellulose nanocrystals from green sources for sustainable innovation.

Cellulose nanocrystals (CNCs) are a class of materials that have received significant attention in recent years due to their unique properties and potential applications. CNCs are extracted from plant fibers and possess high strength, stiffness, and biocompatibility, making them attractive materials for use in various fields such as biomedical engineering, renewable energy, and nanotechnology. This provides an in-depth discussion of the extraction, characterization, and promising applications of CNCs.

An intrusion detection model based on Convolutional Kolmogorov-Arnold Networks.

The application of artificial neural networks (ANNs) can be found in numerous fields, including image and speech recognition, natural language processing, and autonomous vehicles. As well, intrusion detection, the subject of this paper, relies heavily on it. Different intrusion detection models have been constructed using ANNs.

Tailoring UV Penetration Depth in Photopolymer Nanocomposites: Advancing SLA 3D Printing Performance with Nanofillers.

This study examines the influence of nanofillers on the ultraviolet (UV) penetration depth of photopolymer resins used in stereolithography (SLA) 3D printing, and their impact on printability. Three nanofillers, multiwalled carbon nanotubes (MWCNT), graphene nanoplatelets (xGNP), and boron nitride nanoparticles (BNNP), were incorporated into a commercially available photopolymer resin to prepare nanocomposite formulations. The UV penetration depth (Dp) was assessed using the Windowpane method, revealing a significant reduction with the addition of nanofillers.

Fitting of Soil-Water Characteristic Curves (SWCC) of Bukit Mewah, Malaysia soil using field monitoring dataset.

Rainfall-induced landslides are a frequent geohazard for tropical regions with prevalent residual soils and year-round rainy seasons. The water infiltration into unsaturated soil can be analyzed using the soil-water characteristic curve (SWCC) and permeability function which can be used to monitor and predict incoming landslides, showing the necessity of selecting the appropriate model parameter while fitting the SWCC model. This paper presents a set of data from six different sections of the studied slope at varying depths that are used to test the performance of three SWCC models, the van Genuchten-Mualem (vG-M), Fredlund-Xing (F-X) and Gardner (G).

Experimental and numerical analysis of pGFRP and wood cross-arm in latticed tower: a comprehensive study of mechanical deformation and flexural creep.

The adoption of pultruded glass fibre-reinforced polymer (pGFRP) composites as a substitute for traditional wooden cross-arms in high transmission towers represents a relatively novel approach. These materials were selected for their high strength-to-weight ratio and lightweight properties. Despite various studies focusing on structures improvement, there still have a significant gap in understanding the deformation characteristics of full-scale cross-arms under actual operational loads.

Lignosulfonate-based deflocculant and its derivatives for water-based drilling mud: A review.

Chromium-based lignosulfonate (CrLS) deflocculants that are commonly used in water-based drilling muds (WBDMs) to deflocculate bentonites under high temperature (HT), high-pressure (HP), and high-salinity (HS) oil well drilling conditions have been found to contain heavy metals such as chromium, which is toxic and degrades rapidly. However, different ways of addressing this issue have been proffered, including the use of natural polymers such as starch, cellulose, or anionic inorganic agents such as sodium polyphosphates with little or no impact. Other lignosulfonate (LS)-based deflocculants, like sodium-based LS and bio-based LS, have shown a number of benefits, such as being better for the environment, more soluble and evenly distributed in WBDMs, more resistant to salt contamination, easily biodegradable, safe, and able to go through different chemical changes.

New Insights into the Modifications and Bioactivities of Indole-3-Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review.

Indole, a ubiquitous structural motif in bioactive compounds, has played a pivotal role in drug discovery. Among indole derivatives, indole-3-carboxaldehyde (I3A) has emerged as a particularly promising scaffold for the development of therapeutic agents. This review delves into the recent advancements in the chemical modification of I3A and its derivatives, highlighting their potential applications in various therapeutic areas.

Overview of porous magnesium-based scaffolds: development, properties and biomedical applications.

Magnesium (Mg) and its alloys are revolutionizing the field of interventional surgeries in the medical industry. Their high biocompatibility, biodegradability, and a similar elastic modulus to natural bone make porous Mg-based structures potential candidates for orthopedic implants and tissue engineering scaffolding. However, fabricating and machining porous Mg-based structures is challenging due to their complexity and difficulties in achieving uniform or gradient porosity.

Significance of Marangoni convection in ethylene glycol base hybrid nanofluid flow with viscous dissipation through a porous medium.

The current research deals with analytical analysis of Marangoni convection on ethylene glycol base hybrid nanofluid two-dimension flow with viscous dissipation through a porous medium, which have some important application in mechanical, civil, electronics, and chemical engineering. Two types of nanoparticles one is sliver and other is graphene oxide and ethylene glycol is used as base fluid in this research work. The authors applied appropriate transformations to convert a collection of dimension form of nonlinear partial differential equations to dimensionless form of nonlinear ordinary differential equations.

Characteristics of naturally woven Waru bark fiber for eco-friendly composite reinforcement.

The aim of this study was to investigate the potential of Waru bark fiber (WBF) as a reinforcement material for composites. To achieve this aim, WBF was extracted using a conventional process, to ensure its purity, and then characterized for physical, mechanical, chemical, and thermal properties. Microstructure analysis was performed using Scanning Electron Microscope (SEM) to show uniform and exceptional fiber sheets with naturally woven fiber shapes.

Evaluation of mechanical responses of asphalt mixtures incorporating plastic waste as additives by different compaction efforts and mixing temperatures for a sustainable mixture.

Sustainable pavement is essential for country development, offering durable, environmentally friendly, and cost-effective infrastructure. For Malaysia, sustainable pavement supports Sustainable Development Goals (SDGs) 9 and 11 while addressing road deterioration caused by increasing traffic volumes and loads. This deterioration shortens pavement service life and necessitates frequent maintenance, driving the need for innovative solutions.

Controlled Synthesis of Perovskite Nanocrystals at Room Temperature by Liquid Crystalline Templates.

Perovskite nanocrystals (PNCs) are promising active materials because of their outstanding optoelectronic properties, which are finely tunable via size and shape. However, previous synthetic methods such as hot-injection and ligand-assisted reprecipitation require a high synthesis temperature or provide limited access to homogeneous PNCs, leading to the present lack of commercial value and real-world applications of PNCs. Here, we report a room-temperature approach to synthesize PNCs within a liquid crystalline antisolvent, enabling access to PNCs with a precisely defined size and shape and with reduced surface defects.

Efficient biodiesel production from waste cooking oil using a bifunctional Ce/Mn/γ-Al₂O₃ catalysts.

As the demand for sustainable energy sources intensifies, biodiesel emerges as a compelling renewable alternative to petroleum-based fuels. Leveraging waste cooking oil (WCO) as a feedstock not only offers an environmentally friendly fuel source but also addresses waste disposal issues. However, biodiesel production from WCO faces challenges, particularly due to its high free fatty acid (FFA) content, which can hinder efficient conversion and lead to soap formation in traditional alkaline-catalysed processes.

Development and validation of trigger tools in primary care: A scoping review.

In primary care, trigger tools have been utilized to evaluate and identify patient safety events. The use of trigger tools could help clinicians and patients detect adverse events in a patient's medical record. Due to a lack of research on the process development of trigger tools in primary care, the purpose of this scoping review is to investigate the trigger development and validation process in primary care settings.

Water quality assessment of Johor River Basin, Malaysia, using multivariate analysis and spatial interpolation method.

In the Johor River Basin, a comprehensive analysis was conducted on 24 water environmental parameters across 33 sampling sites over 3 years, encompassing both dry and wet seasons. A total of 396 water samples were collected and analyzed to calculate the Water Quality Index (WQI). To further assess water quality and pinpoint potential pollution sources, multivariate techniques such as principal component analysis (PCA) and cluster analysis (CA), alongside spatial analysis using inverse distance weighted (IDW) interpolation, were employed.

Citrate-modified bacterial cellulose as a potential scaffolding material for bone tissue regeneration.

Bacterial cellulose (BC) is a novel biocompatible polymeric biomaterial with a wide range of biomedical uses, like tissue engineering (TE) scaffolds, wound dressings, and drug delivery. Although BC lacks good cell adhesion due to limited functionality, its tunable surface chemistry still holds promise. Here, hydroxyapatite (HA) was incorporated into a citrate-modified BC (MBC) using the biomimetic synthesis in simulated body fluid (SBF).

Temporal trends and predictive modeling of air pollutants in Delhi: a comparative study of artificial intelligence models.

Air pollution monitoring and modeling are the most important focus of climate and environment decision-making organizations. The development of new methods for air quality prediction is one of the best strategies for understanding weather contamination. In this research, different air quality parameters were forecasted, including Carbon Monoxide (CO), Nitrogen Monoxide (NO), Nitrogen Dioxide (NO), Ozone (O), Sulphur Dioxide (SO), Fine Particles Matter (PM), Coarse Particles Matter (PM), and Ammonia (NH).

Enhancing fish sludge bioconversion kinetics for nutrient recovery in aquaponics using a modified biological aerated filter with a novel media of polyhedral hollow spheres.

Nutrient recovery from aquaculture sludge is vital for promoting hydroponic plant growth and achieving near-zero solid waste discharge in aquaponic systems. Modified biological aerated filters (MBAFs) are promising because of the dual capabilities of aquaculture sludge collection and aerobic mineralization. However, the bioconversion kinetics, which is indirectly related to the packed media, need to be improved.

Navigating green synthesized metal-based nanoparticles as anti-inflammatory agent - Comprehensive review.

The biosynthesis of nanomaterials is a vast and expanding field of study due to their applications in a variety of fields, particularly the pharmaceutical and biomedical fields. Various synthetic routes, including physical and chemical methods, have been developed in order to generate metal nanoparticles (NPs) with definite shapes and sizes. In this review, focused on the recent advancements in the green synthetic methods for the generation of silver, zinc and copper NPs with simple and eco-friendly approaches and the potential of the biosynthesized metal and metal oxide NPs as alternative and therapeutic agent for the treatment of inflammatory diseases.

IoT-based remote monitoring system: A new era for patient engagement.

Internet of Things (IoT) is changing patient engagement in healthcare by shifting from traditional care models to a continuous, technology-driven approach using IoT-based Remote Monitoring Systems (IoT-RMS). This research seeks to redefine patient engagement by examining how Internet of Things (IoT) technologies can impact healthcare management and patient-provider interactions at different phases. Additionally, it presents the relationship between patient engagement stages and IoT-RMS, which promotes patients' active participation using technological health management tools.