Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort.

The present study explored for the first time the blood-based proteomic signature that could potentially distinguish older adults with and without cognitive frailty (CF). The participants were recruited under the Malaysian Elders Longitudinal Research (MELoR) study. Cognition and physical frailty were determined using the Montreal Cognitive Assessment (MoCA) and Fried's criteria, respectively.

Spatial patterns of colorectal cancer survival rates in Malaysia, 2013-2018.

Background: Large geographical variations in colorectal cancer (CRC) survival rates have been reported across regions. Poorer survival rates were mainly found in socioeconomically deprived areas, highly dense areas, and areas lacking healthcare accessibility. The objective of this study was to identify, compare, and contrast the spatial patterns of 5-year CRC-specific survival rates and identify high-priority areas by districts in Malaysia.

Federated learning-driven collaborative recommendation system for multi-modal art analysis and enhanced recommendations.

With the rapid development of artificial intelligence technology, recommendation systems have been widely applied in various fields. However, in the art field, art similarity search and recommendation systems face unique challenges, namely data privacy and copyright protection issues. To address these problems, this article proposes a cross-institutional artwork similarity search and recommendation system (AI-based Collaborative Recommendation System (AICRS) framework) that combines multimodal data fusion and federated learning.

Ethyl (2,3,4)-1-ethyl-2-(furan-2-yl)-4-hy-droxy-5-oxopyrrolidine-3-carboxyl-ate.

The title racemic oxopyrrolidine compound, CHNO, contains three stereogenic centres and crystallizes with two mol-ecules in the asymmetric unit. The five-membered pyrrolidine rings in both mol-ecules exhibit envelope conformations. The -ethyl group of one of the mol-ecules is disordered over two sets of sites in a 0.

Understanding climate literacy research using scientometrics analysis.

Climate literacy, critical for understanding both the individual's impact on climate and the consequential effects on society and the biosphere, is comprehensively examined in this study through scientometric analysis. Spanning research from 1981 to 2024 and utilizing the Web of Science database, this study maps the evolution of publication trends, pinpoints central themes, and identifies pivotal publications within the domain. Leveraging advanced visualization tools like CiteSpace, the research employs dual-map overlays and document co-citation analysis to uncover the intricate web of interconnections among scholarly works.

Dexibuprofen loaded into nanoemulsion based gel for topical application - In vitro characterization and in vivo anti-inflammatory evaluation.

Arthritic disease is one of the most common diseases in adults and a leading cause of joint degeneration. Dexibuprofen (DEX) is routinely used for the treatment of rheumatoid arthritis, acute postoperative pain, primary dysmenorrheal, and in lower back pain. However, it is poorly water soluble with compromised bioavailability, and hence has limited therapeutic activity.

The efficacy of vagus nerve stimulation for epilepsy in Malaysia.

Introduction: The first vagus nerve stimulation (VNS) implantation in Malaysia was back in 2000, and the implantation rate increased tremendously since 2019. VNS has been used in patients who had persistent seizures despite epilepsy surgeries or were not candidates for epilepsy surgeries. We aimed to study the efficacy of VNS in Malaysia.

A comprehensive review of lignin-reinforced lignocellulosic composites: Enhancing fire resistance and reducing formaldehyde emission.

The rising environmental concerns and the growing demand for renewable materials have surged across various industries. In this context, lignin, being a plentiful natural aromatic compound that possesses advantageous functional groups suitable for utilization in biocomposite systems, has gained notable attention as a promising and sustainable alternative to fossil-derived materials. It can be obtained from lignocellulosic biomass through extraction via various techniques, which may cause variability in its thermal, mechanical, and physical properties.

Repeated time-series cross-validation: A new method to improved COVID-19 forecast accuracy in Malaysia.

Forecasting COVID-19 cases is challenging, and inaccurate forecast values will lead to poor decision-making by the authorities. Conversely, accurate forecasts aid Malaysian government authorities and agencies (National Security Council, Ministry of Health, Ministry of Finance, Ministry of Education, and Ministry of International Trade and Industry) and financial institutions in formulating action plans, regulations, and legal acts to control COVID-19 spread in the country. Therefore, this study proposes Repeated Time-Series Cross-Validation, a new data-splitting strategy to identify the best forecasting model that is capable of producing the lowest error measures value and a high percentage of forecast accuracy for COVID-19 prediction in Malaysia.

RETRACTED: Azra et al. Crayfish Research: A Global Scientometric Analysis Using CiteSpace. 2023, , 1240.

The journal retracts the article titled "Crayfish Research: A Global Scientometric Analysis Using CiteSpace" [...

A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine related disorders.

The endocrine system is a complex network of glands that produce and release hormones that regulate various physiological processes. In the past few decades, the human skin has been identified as an important peripheral endocrine organ that is the main site for the synthesis of vitamin D through exposure to sunlight. Mutations in downstream vitamin D-related gene pathways are associated with disease development.

Repurposing the antipsychotic drug penfluridol for cancer treatment (Review).

Cancer is one of the most prevalent diseases and the leading cause of death worldwide. Despite the improved survival rates of cancer in recent years, the current available treatments often face resistance and side effects. Drug repurposing represents a cost‑effective and efficient alternative to cancer treatment.

Physio-Mechanic and Microscopic Analyses of Bioactive Glass-Based Resin Infiltrants.

This study aimed to investigate the efficacy and durability of bioactive glass-based dental resin infiltrants. Resin infiltrants were formulated by combining photoinitiated dimethacrylate monomers with three variations of bioactive glass: 45S5 Bioglass (RIS), boron-substituted (RIB), fluoride-substituted (RIF), and pure resins (PR), whereby TOOTH group (TH) and ICON (CN) served as commercial control groups. Teeth samples were prepared, and experimental and control infiltrants were applied on demineralized human-extracted teeth.

Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure.

Purpose: This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia.

Methods: 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF were surveyed using the EQ-5D-5 L questionnaire. The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD).

Improving patient safety and access to healthcare: The role of pharmacist-managed clinics in optimizing therapeutic outcomes.

Contemporary patient care requires a multidisciplinary approach to monitoring, assessing, and managing diseases. Promoting multidisciplinary approaches encourages the purposeful participation of many healthcare professionals and harnessing their combined knowledge to provide tailored treatment plans. Pharmacists, skilled and knowledgeable professionals in medication management, drug-related problems, and disease prevention, can offer vital interventions that contribute to improved patient outcomes.

The influence of emotional intelligence on knowledge, perception and readiness on Telepharmacy.

Introduction: Emotional Intelligence (EI) involves skills to recognise, comprehend, and manage emotions that influence thinking. Using EI allows for the integration of emotion into reasoning and problem-solving. If applied effectively, EI can foster positive emotions that promote the deployment of telepharmacy, which involves delivering pharmaceutical services remotely via telecommunication.

Exploring Betel Quid Chewing Among Orang Asli: A Qualitative Study.

Betel quid chewing is a culturally significant practice among the indigenous people (Orang Asli) in Malaysia, but it poses serious health risks, including oral cancer and systemic diseases. Studies on betel quid chewing are limited, making it difficult to develop effective public health interventions. This study aimed to explore the cultural significance, perceived health effects, and misconceptions surrounding betel quid chewing among the indigenous people, assess their awareness of health risks, and explore factors influencing their intentions to quit or reduce betel quid chewing.

Performance of yellow and pink oyster mushroom dyes in dye sensitized solar cell.

A solar photovoltaic (PV) cell, is an electrical device that uses the PV effect to convert light energy into electricity. The application of oyster mushroom dyes in dye sensitized solar cell (DSSC) is a novel strategy to substitute the costly chemical production process with easily extractable, environmentally acceptable dyes. Both dyes of yellow and pink oyster mushrooms were extracted using the same process but dried into powder form using two techniques, warm drying and freeze drying.