Exploring the role of Bisphenol A in obesity-driven colorectal cancer progression: network toxicology and multi-organ pathology in animal models.

Bisphenol A (BPA), an endocrine disruptor, is linked to cancer progression in estrogen-responsive tissues, but its role in promoting colorectal cancer (CRC) progression in the context of obesity remains underexplored. This study examines BPA's influence on CRC in obese Sprague-Dawley rats using network toxicology and experimental models. Computational analysis using the Database for Annotation, Visualization, and Integrated Discovery identified pathways such as "CRC" and "chemical carcinogenesis-receptor activation", implicating the PI3K-AKT pathway in IL-1 beta upregulation and BPA's role in CRC during obesity.

Extraction and characterization of sodium alginate from native Malaysian brown seaweed Sargassum polycystum.

Malaysian seaweed, particularly Sargassum polycystum, has potential for alginate production, yet an extraction protocol for this seaweed remains lacking. This study aimed to optimize the extraction process to maximize alginate yield while characterizing the physicochemical properties of the extracted alginate and its potential applications. An alkali-based extraction method was employed, with key parameters, including alkali concentration, extraction temperature, and time, carefully optimized to yield 30.

Clinacanthus nutans crude polysaccharide extract as a green platform for microwave-assisted synthesis of silver nanoparticles: Optimization, characterization, and evaluation of bioactivities.

Clinacanthus nutans (C. nutans) is a plant in tropical Asia with proven biological activities. The optimized extraction method of C.

Interferon-γ induces biphasic changes in caldesmon localization as well as adherens junction organization and expression in HUVECs.

Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ disrupts the endothelial barrier have not been clarified.