Factors associated with post-stroke fatigue among stroke survivors: a cross-sectional study.

Background: Post-stroke fatigue (PSF) is a common complication experienced by stroke survivors. These individuals often confront psychological challenges such as depression and anxiety, along with significant obstacles like reduced quality of life (QoL) and limitations in activities of daily living (ADLs). Such challenges can profoundly affect their overall recovery and well-being.

Identifying leptospirosis hotspots in Selangor: uncovering climatic connections using remote sensing and developing a predictive model.

Background: Leptospirosis is an endemic disease in countries with tropical climates such as South America, Southern Asia, and Southeast Asia. There has been an increase in leptospirosis incidence in Malaysia from 1.45 to 25.

Benchmarking the high conductive two-dimensional layered structured NbS, ZrS, ReS and NbSe materials with zero energy bandgap ( ) for photocatalytic application: a DFT study.

Two-dimensional materials are among the most scientifically accessible materials in material science at the beginning of the twenty-first century. There has been interest in the monolayer transition metal dichalcogenide (TMDC) family because of its large active site surface area for UV photons of light for wastewater treatment. In the present work, density functional theory (DFT) is utilized to model the optical, structural and electrical properties of TMDCs such as NbS, ZrS, ReS and NbSe using the GGA-PBE simulation approximation.

Myiasis in the Neglected Tracheostomy Wound.

Myiasis is the term referring to an infestation of dipterous larvae in the living body tissue, where they feed on the tissue and cause infection. It is typically found in individuals living in unhygienic conditions, with foul-smelling odor emanating from neglected wounds or body discharge, which attract flies to lay their eggs in the affected area. Myiasis can cause life-threatening complications if maggots invade vital organs, resulting in sepsis, hemorrhage, and organ dysfunction.

Integration of physio-biochemical, biological and molecular approaches to improve heavy metal tolerance in plants.

Heavy metal toxicity hinders plant growth and development by inducing oxidative stress, decreasing biomass, impairing photosynthesis, and potentially leading to plant death. The inherent defense mechanisms employed by plants, including metal sequestration into vacuoles, phytochelation, cell wall metal adsorption and an enhanced antioxidant system can be improved via various approaches to mitigate heavy metal toxicity. This review primarily outlines plants direct and indirect responses to HM stress and the tolerance mechanisms by which plants combat the toxic effects of metals and metalloids to understand the effective management of HMs and metalloids in the soil system.

Basic Psychological Needs and Psychological Well-Being Among Undergraduate Students in China: The Mediating Role of Autonomous Motivation and Academic Engagement.

Purpose: From the perspective of positive psychology, and based on Self-Determination Theory and Sustainable Happiness Theory, this study explores the relationship between basic psychological needs and psychological well-being among undergraduate students, as well as the mediating roles of autonomous motivation and academic engagement.

Methods: A survey was conducted among 439 undergraduate students using the Basic Psychological Needs Scale, Learning Motivation Scale, Academic Engagement Scale, and Psychological Well-being Scale.

Results: Basic psychological needs were significantly and positively correlated with undergraduate students' psychological well-being.

Safety assessment of resveratrol surrogate molecule 5 (RSM5): Acute and sub-acute oral toxicity studies in BALB/c mice.

Natural polyphenols have gained greater attention for their potent medicinal properties and potential benefits in addressing various health concerns. Resveratrol, a polyphenolic compound known for its therapeutic properties, has shown limitations in bioavailability, which the novel derivative resveratrol surrogate molecule (RSM5) aims to improve. The present study evaluates the oral toxicity and safety profile of a novel resveratrol derivative through acute and subacute assessments.

Optimization and comparative study of consortia for cellulolytic potential and cellulase enzyme activity.

Lignocellulosic biomass, owing to its recalcitrant nature, requires a consortium of enzymes for its breakdown. The present study deals with the isolation of cellulolytic bacterial strains from landfill leachate collected from the Pulau Burung landfill site of Penang, Malaysia, and consortia were constructed to test their cellulolytic efficiency. The dinitro salicylate method was used for the estimation of enzyme activity, and consortia were compared with promising bacterial strains.

18-year plant reproductive phenology dataset from Lambir, Borneo, including four large general flowering events.

Flowering and fruiting phenology can have large impacts on a plant's reproductive success. In many plant species, these phenological events are controlled by seasonal climatic cues, resulting in one-year reproductive cycles. However, parts of SE Asian tropical forests have an aseasonal climate with irregular fluctuations.

Key insights into recommended SMS spam detection datasets.

Short Message Service (SMS) spam poses significant risks, including financial scams and phishing attempts. Although numerous datasets from online repositories have been utilized to address this issue, little attention has been given to evaluating their effectiveness and impact on SMS spam detection models. This study fills this gap by assessing the performance of ten SMS spam detection datasets using Decision Tree and Multinomial Naïve Bayes models.

Palm-based nanocrystal cellulose-stabilized Pickering emulsions: investigating characteristics, stability and in vitro digestion for potential application as substitution of coconut milk.

Background: Coconut milk encounters challenges related to global sustainability and its high fat content, which may potentially have adverse effects on health. Nanocrystal cellulose (NCC) has gained attention due to its amphiphilic nature, high aspect ratio and large elastic modulus, making it a beneficial natural stabilizer for emulsion stabilization. Recent studies have demonstrated that NCC plays a role in modulating gastrointestinal digestion.

Matching-Adjusted Indirect Comparison of Daratumumab-Pomalidomide-Dexamethasone and Pomalidomide-Bortezomib-Dexamethasone in Relapsed/Refractory Multiple Myeloma.

Background: Standard-of-care treatment for patients with multiple myeloma (MM) typically includes frontline lenalidomide until disease progression, making lenalidomide-refractoriness a challenge in relapsed/refractory MM (RRMM). Lenalidomide-sparing triplet therapies, daratumumab, pomalidomide, and dexamethasone (DPd) and pomalidomide, bortezomib, and dexamethasone (PVd), demonstrated efficacy in lenalidomide-exposed patients in the APOLLO and OPTIMISMM trials, respectively. Without head-to-head trial data, we assessed the comparative effectiveness of DPd versus PVd via matching-adjusted indirect comparison (MAIC).

Plant extracts as a source of antiviral agents against influenza A virus.

The influenza virus, especially influenza A (IAV), has remained a constant global health threat due to its high morbidity rate and ability to undergo antigenic shifts and drifts, causing pandemics and epidemics. Due to the rapid evolution of IAV, novel therapeutics are urgently required to combat these viruses effectively, as they develop resistance against current therapeutics. Natural products have been the subject of debate for alternative IAV therapy, where the abundance of bioactive compounds offers numerous potentials for novel anti-IAV drug discovery.

Translation, Adaptation, and Validation of the Professional Collaborative Practice Tool for Community Pharmacists and Physicians in Arabic-Speaking Countries.

Background: The importance of collaboration between physicians and community pharmacists in healthcare is increasingly recognized. Enhanced cooperation positively impacts medication management and patient outcomes by merging medical and pharmaceutical expertise for improved health care. Previously, the Professional Collaborative Practice Tool, which is crucial for assessing such collaboration, was unavailable in Arabic.

Enhancing therapeutic efficacy of Fingolimod via Intranasal Delivery in an Ethidium Bromide-induced Model of Multiple Sclerosis.

Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune neurological characterized by muscle weakness, numbness, tingling, vision problems, and difficulty in coordination and balance caused by the damage of myelin content around the nerve fibres. The recent literature is evident that along with their lymphocyte attack prevention mechanism, fingolimod (FNG) can serve as neuroprotective also by ensuring their improved brain availability. Therefore, in this project brain availability of FNG was enhanced by delivering the FNG in the form of nanoparticles.

Nanocoating of quinoa protein and hyaluronic acid enhances viability and stability of Limosilactobacillus fermentum RC4 microcapsules.

Nanocoating represents an effective strategy for creating a protective barrier on probiotic surfaces, preventing them from damage. Here, we developed HAQ microcapsules comprising Limosilactobacillus fermentum RC4, which were nanocoated with hyaluronic acid and quinoa protein. We characterized the stability and safety, and investigated the intermolecular forces and transcriptome to elucidate the mechanisms underlying the nanocoating.

Effectiveness of online and offline blended teaching methods using a mobile application on surgical nursing apprenticeship: A clustered randomised controlled trial.

Background: Although online and offline blended teaching has emerged as a new teaching method, little research has been conducted on teaching clinical nursing skills and even less on the online teaching of this aspect of nursing apprenticeships.

Aim: This study aimed to evaluate a blended online and offline teaching module for surgical nursing apprenticeship using the Learning Pass mobile application.

Design: A clustered randomised control trial was conducted among 166 nursing students at a university.

A comprehensive review of fused imidazonaphthyridine derivatives: Synthetic approaches and biological applications.

Fused heterocyclic imidazonaphthyridine compounds stand at the forefront of global research, captivating remarkable interest in medicinal and synthetic organic chemistry. These compounds possess a range of potent biological and pharmacological properties, rendering them invaluable for medical and therapeutic research, particularly in drug design and discovery. Despite their significance, no dedicated review has focused on fused heterocyclic imidazonaphthyridine derivatives.

Foam-based mustard essential oil microcapsules preparation, characterization, grilling application and comparison with emulsion microcapsules.

Emulsion-based microencapsulation is the dominant form of encapsulating target components. Foam of emulsions is a neglected and important form of encapsulation due to its lower substance content, large specific surface area, and stable water-oil emulsion interface, which is equally feasible for drying and encapsulation. In this study, using the encapsulation of a small amount of mustard essential oil (MEO) as an example, the differences in physicochemical properties between foam-based and emulsion-based MEO microcapsules were evaluated by preparing protein (soybean isolate protein) and polysaccharide (sodium alginate) emulsion systems with a high amount of foaming, collecting the foams and drying (hot air drying and freeze-drying).

Effects of functional training on skill performance and movement quality among skilled youth male tennis players: A cluster randomized control trial.

Purpose: Functional training to improve athletes' technical performance and movement quality is becoming increasingly popular, but few studies have focused on young tennis players. The aims of this study were to compare the effects of 12 weeks of functional training on skilled youth male tennis players' skill performance and movement quality.

Methods: Forty skilled youth male tennis players were assigned to the functional training group (n = 20) or the control training group (n = 20).

Serial multiple mediation of perceived stress and self-control in the relationship between neuroticism and career anxiety among nursing interns in China: a cross-sectional questionnaire survey.

Background: Nursing internship play a crucial role in cultivating nursing students. However, nursing interns often face challenges of career anxiety, which can have negative impacts on their professional development and work quality. Therefore, understanding the factors influencing career anxiety among nursing interns is important.

Prevalence of Mpox vaccine acceptance and hesitancy among people living with HIV: a comprehensive systematic review and meta-analysis.

Background: Vaccine acceptance among People Living with HIV (PLWH) is crucial for managing and mitigating the spread of infectious diseases, including Mpox. This systematic review and meta-analysis assess the rate of vaccine acceptance for Mpox among PLWH and identify factors influencing these rates.

Methods: We searched major databases including PubMed, Embase, and Web of Science up to 30 August 2024 for observational studies involving PLWH that reported on mpox vaccine acceptance rates.

Holistic horizons: understanding the landscape of traditional and complementary medicines among menopausal women in Kuala Lumpur.

Background: The use of traditional and complementary medicines (T&CM) among menopausal women has become prevalent due to the concerns on the adverse effects and differing opinions regarding hormone replacement therapy's (HRT) suitability for long-term following the release of Women's Health Initiative (WHI) results in 2002. To date, there have been no studies conducted on knowledge, attitude and practice towards T&CM among menopausal women in Malaysia. In addition, many women seek relief from menopausal symptoms by using T&CM despite questionable safety and efficacy.

An 8-year-old girl with secondary histiocytic sarcoma with BRAF mutation following T-cell acute lymphoblastic leukemia demonstrating stable disease for 3 years on dabrafenib and trametinib - a case report and literature review.

Background: Histiocytic sarcoma as a secondary malignancy following childhood leukemia is extremely uncommon with fewer than 20 cases reported worldwide. They often pose a diagnostic challenge and prognosis is dismal. There is a lack of well-established clinical treatment protocols owing to rarity of disease.