Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C-H Functionalization of 3-Iodooxetane for the Synthesis of 1,5-Dioxaspiro[2.3]hexanes.

Strained spiro-heterocycles (SSH) have gained significant attention within the medicinal chemistry community as promising (sp3)-rich bioisosteres for their aromatic and non-spirocyclic counterparts. We herein report access to an unprecedented spiro-heterocycle - 1,5-dioxaspiro[2.3]hexane.

Exploring Bangladeshi English as a foreign language learners' mindfulness and engagement in the online learning context.

This empirical study investigates the relationship between mindfulness and online engagement among Bangladeshi English as a Foreign Language (EFL) learners during the Covid-19 pandemic. A mixed-methods approach was employed, combining quantitative data from the Langer Mindfulness Scale (LMS) and the Online Student Engagement Scale (OSES) with qualitative data from open-ended responses. A total of 215 university students participated in the study, providing insights into their mindfulness levels and engagement in online learning.

Theoretical Study of CO, NO, NO, Cl, and HS Adsorption Interactions with PdO-Graphene Composites for Gas Sensor Applications.

Gas sensors play a vital role in detecting gases in the air, converting their concentrations into electrical signals for industrial, environmental, and safety applications. This study used density functional theory methods to explore the mechanism and sensitivity of a PdO-graphene composite sensor towards various gases (CO, NO, NO, HS, and Cl). All calculations, including structure, energy, and frequency optimizations, were performed using the Gaussian software with appropriate configurations and basis sets.

Effectiveness of artificially planted mangroves on remediation of metals released from ship-breaking activities.

The pervasive and escalating issue of toxic metal pollution has gathered global attention, necessitating the exploration of innovative ecological strategies like phytoremediation. This study explored the extent of potentially toxic metal contamination status and the effectiveness of three planted mangrove species (Avicennia marina, Bruguiera gymnorhiza,and Excoecaria agallocha) in phytoremediation efforts to reduce pollution level. The results indicated that the mean concentrations of elements in the sediment of the area followed a descending sequence: Fe (27,136.

Overcoming low status or maintaining high status? A multinational examination of the association between socioeconomic status and honour.

We examined the relationship between socioeconomic status (SES) and endorsement of honour. We studied the SES-honour link in 5 studies (N = 13,635) with participants recruited in different world regions (the Mediterranean and MENA, East Asian, South-East Asian, and Anglo-Western regions) using measures that tap into various different facets of honour. Findings from these studies revealed that individuals who subjectively perceived themselves as belonging to a higher (vs.

Dynamic linkages and spillover effects of biodiversity risk in socially responsible investment and commodity markets.

This study employs a novel biodiversity risk measure, developed through textual analysis, to examine how biodiversity risk affects socially responsible investment (SRI) and commodity markets. Biodiversity-related financial risks, arising from ecosystem degradation, represent an emerging and underexplored dimension of market risk, particularly for investors seeking sustainability-aligned portfolios. Our analysis reveals that both SRI equity and commodity indices consistently exhibit negative time-varying correlations with biodiversity risk, with correlations as low as -0.

Effects of stocking density on growth performance, digestive enzyme activity, biochemical composition, and economic efficiency of a new strain of reared in cage culture system at Sindh Pakistan.

The latest strain of is an altered ecological adaptation for sustainable aquaculture and is necessary to sustain stocking density and reduce physiological stress of the new strain. The present study aimed to determine the optimum stocking density, biological performance, and economic efficiency of the Nile tilapia. The 14,000 healthy seeds and uniform weight (40 ± 2.

Trends in Aptasensing and the Enhancement of Diagnostic Efficiency and Accuracy.

The field of healthcare diagnostics is navigating complex challenges driven by evolving patient demographics and the rapid advancement of new technologies worldwide. In response to these challenges, these biosensors offer distinctive advantages over traditional diagnostic methods, such as cost-effectiveness, enhanced specificity, and adaptability, making their integration with point-of-care (POC) platforms more feasible. In recent years, aptasensors have significantly evolved in diagnostic capabilities through the integration of emerging technologies such as microfluidics, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems, wearable devices, and machine learning (ML), driving progress in precision medicine and global healthcare solutions.

Characteristics, Contamination Levels, and Ecosystem Risk Assessment of Microplastics in Surface Water of a Highly Urbanized River from a Developing Country.

Microplastic (MP) contamination poses significant risks to ecosystems and human health. However, the absence of standardized protocols, detailed polymer identification, and sources identification hinders the development of targeted mitigation strategies, particularly in developing nations. There is a scarcity of comprehensive data on MP distribution, sources, and transport mechanisms in freshwater environments.

Green synthesized ZnO and ZnO-based composites for wound healing applications.

In recent years, zinc oxide nanoparticles (ZnO NPs) have gained much attention in biomedical applications because of their distinctive physicochemical features such as low toxicity and biocompatible properties. Traditional methods to produce ZnO NPs sometimes include harmful substances and considerable energy consumption, causing environmental issues and potential health risks. Nowadays, the concern of ZnO production has moved toward environmentally friendly and sustainable synthesis methods, using natural extracts or plant-based precursors.

Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.

There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers.

Contrasting environmental drivers of tree community variation within heath forests in Brunei Darussalam, Borneo.

Understanding how abiotic factors influence Bornean tropical tree communities and diversity is a key aspect in elucidating the mechanisms of species co-existence and habitat preferences in these biodiverse forests. We focused on investigating forest structure, tree diversity and community composition of lowland Bornean heath forests in Brunei Darussalam, within two 0.96 ha permanent forest plots at Bukit Sawat Forest Reserve and Badas Forest Reserve.

Development and validation of the renal dosing questionnaire (RDQ-13) for pharmacists.

Pharmacists, as an integral part of the healthcare team, can play a crucial role in preventing drug-related problems in patients with chronic kidney disease that arise due to inappropriate doses. This study aimed to develop and validate a new tool, the renal dosing questionnaire (RDQ-13), for pharmacists working across hospital, community, and retail pharmacy settings. A cross-sectional study was conducted from January to March 2023 among pharmacists working in different settings.

Multiple mini-interviews as admission process: A study on perception of health science students in Universiti Brunei Darussalam.

Background: As multiple mini-interviews (MMI) have grown in popularity in selecting applicants to health science programmes, it is essential to comprehend students' views towards MMI and its usefulness in the admissions process. The study aims to explore students' perceptions on the usefulness and satisfaction of the MMI as an admission process into the health science programmes offered in Universiti Brunei Darussalam (UBD).

Methods: A cross-sectional study using a self-administered questionnaire was distributed to all Year 1 and 2 health sciences students in the university.

NbCTx-supported bimetallic NPs@ZIF-8 nanohybrid as ECL signal amplifier and peroxidase mimics for chromogranin a immunosensing in human serum and saliva.

Niobium carbide (NbCTx), a key component of the MXene family renowned for its utilization in lithium-ion batteries and supercapacitors, remains largely underutilized in biosensing applications. This study introduces a notably sensitive and label-free dual-mode electrochemiluminescence (ECL) and colorimetric immunosensor to specifically detect chromogranin A (CgA) in biological fluids. Initially, AuAg bimetallic nanoparticles (BiMNPs) were synthesized using NbCTx as a reducing and supporting material.

Erratum: Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021.

[This corrects the article DOI: 10.1016/j.eclinm.

Corrigendum to "Dementia diagnostic and treatment services in the Western Pacific: challenges, preparedness and opportunities in the face of amyloid-targeting therapies" [The Lancet Regional Health-Western Pacific, Volume 50, September 2024, 101183].

[This corrects the article DOI: 10.1016/j.lanwpc.

Decoding Newly Graduated Midwives: A Value-Based Philosophy of Vocational and Professional Midwifery Program in Indonesia.

Aim/objective: This study aims to provide a comprehensive overview of the current education programs and the advancements in vocational and professional education programs in Indonesia. These advancements are a direct result of the 2019 Midwifery Law, which has significantly influenced the landscape of midwifery education in the country.

Background: The history of midwifery education in Indonesia reveals a long-standing trend where the field was shaped by authorities and disciplines outside of midwifery.

The relationship between the use of screen-based devices and self-reported sleep quality in adolescents aged 13-19 years in Brunei.

Background: The widespread use of digital devices among adolescents has raised concerns about the potential impact of screen time on sleep quality. This study aimed to investigate the relationship between screen time and self-reported sleep quality in adolescents.

Methods: A cross-sectional study was conducted on adolescents (13- to 19-year-olds) using multi-stage cluster sampling with probability proportional to the size of public schools.

Global burden of disease attributable to metabolic risk factors in adolescents and young adults aged 15-39, 1990-2021.

Background: Metabolic risk factors are a significant cause of global burden among adolescents and young adults, but there is a lack of attention to the burden attributable to these metabolic risk factors globally.

Aims: This study aims to provide comprehensive estimates of five important metabolic risk factors and the attributable disease burden in people aged 15-39 years from 1990 to 2021, based on the Global Burden of Disease Study (GBD) database.

Methods: Global total deaths and disability-adjusted life years (DALYs) were used to describe the burden attributable to five common metabolic risk factors, including high fasting plasma glucose (FPG), high low-density lipoprotein cholesterol (LDL-C), high systolic blood pressure (SBP), high body mass index (BMI), and kidney dysfunction, in adolescents and young adults.