Epilepsy and sudden unexpected death in epilepsy in a mouse model of human -linked developmental and epileptic encephalopathy.

Voltage-gated sodium channel β1 subunits are essential proteins that regulate excitability. They modulate sodium and potassium currents, function as cell adhesion molecules and regulate gene transcription following regulated intramembrane proteolysis. Biallelic pathogenic variants in , encoding β1, are linked to developmental and epileptic encephalopathy 52, with clinical features overlapping Dravet syndrome.

Combined dexamethasone/CRF test in remitted outpatients with recurrent major depressive disorder.

Background: Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is a prominent neurobiological finding during a major depressive episode, reflecting a state dependent factor. An issue under investigation is whether the dysfunction of the HPA axis has also a role to play as a state-independent or trait factor for major depressive disorder (MDD). In relation to this, it is important to examine HPA axis function in patients who are clinically remitted from depression.

[Education in basic clinical skills for doctors].

There was reason to believe there were problems regarding basic clinical skills in the medical undergraduate curriculum. 106 students from three groups of final year students at two medical schools (i.e.