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Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile).

Biochem Pharmacol

July 2005

Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Drie Eiken Campus, Universiteitsplein 1 building S6 B-2610 Antwerpen (Wilrijk), Belgium.

Inger Brandt Jurgen Joossens Xin Chen Marie-Berthe Maes Simon Scharpé

Vildagliptin (NVP-LAF237/(2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile) was described as a potent, selective and orally bio-available dipeptidyl-peptidase IV (DPP IV, EC 3.4.14.

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Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile).