3 results match your criteria: "Universiteitsplein 1 Building T[Affiliation]"
Contribution of transient and sustained calcium influx, and sensitization to depolarization-induced contractions of the intact mouse aorta.
BMC Physiol
September 2012
Laboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1 Building T, 2.18, Wilrijk B-2610, Belgium.
Background: Electrophysiological studies of L-type Ca2+ channels in isolated vascular smooth muscle cells revealed that depolarization of these cells evoked a transient and a time-independent Ca2+ current. The sustained, non-inactivating current occurred at voltages where voltage-dependent activation and inactivation overlapped (voltage window) and its contribution to basal tone or active tension in larger multicellular blood vessel preparations is unknown at present. This study investigated whether window Ca2+ influx affects isometric contraction of multicellular C57Bl6 mouse aortic segments.
View Article and Find Full Text PDFA manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics.
Int J Biol Sci
January 2010
Laboratory of Protein Chemistry, Proteomics and Signal Transduction, Department of Biomedical Sciences, University of Antwerp (Campus Drie Eiken), Universiteitsplein 1 - Building T, Wilrijk, Belgium.
Article Synopsis
- PML-NBs are dynamic nuclear aggregates that play a crucial role in cellular functions, and the study aims to better understand their interactions.
- A comprehensive network, called 'the PML-ome', has been created by reviewing existing literature to identify proteins associated with PML-NBs.
- The research suggests that PML-NBs could act as a central site for SUMOylation, based on the presence of SUMO pathway interactors and a prediction model highlighting SUMOylatable proteins within these nuclear bodies.
Corticotropin-releasing factor-binding protein, stress and major depression.
Ageing Res Rev
May 2005
Department of Molecular Genetics VIB8, Flanders Interuniversity Institute for Biotechnology, University of Antwerp (UA), Universiteitsplein 1/Building T, B-2610 Antwerpen, Belgium.
Major depressive disorder (MDD) is characterized by a dysregulation of the stress response system. A corticotropin-releasing factor (CRF) hyperdrive is a consistent and well-documented finding. CRF-binding protein (CRF-BP) may play a role in the pathogenesis of MDD.
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