779 results match your criteria: "Universiteit Utrecht[Affiliation]"

Silicon-based Linkers for Tunable Acid-Sensitive Drug Release from Polymeric Nanoparticles.

Chemistry

December 2024

University of Glasgow, Chemistry, University Avenue, G12 8QQ, Glasgow, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Active Pharmaceutical Ingredients (APIs) may benefit from a carrier to improve their pharmacokinetic and pharmacodynamic properties. Core-crosslinked polymeric micelles (CCPMs) are carriers for hydrophobic small molecule APIs. In CCPMs, APIs are generally covalently coupled to the core of the micelles by use of a linker, which can be tailored to adjust the release rate of the API.

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Purpose: As the global population aged 60+ grows, ensuring mobility and independence for older adults is a critical public health goal. This paper examines barriers to life-space mobility in older adults and explores wearable lower limb exoskeletons (LLEs) and green exercise as innovative solutions.

Methods: Literature search and interdisciplinary expert input were utilized.

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[Engage patients in making healthcare more environmentally sustainable].

Ned Tijdschr Geneeskd

November 2024

Zorginstituut Nederland, Programma Zorgevaluatie en Gepast Gebruik, Diemen.

Many Dutch patients consider sustainability important and are willing to make sustainable choices, even if this means compromising the effectiveness of their treatment. However, they indicate a lack of knowledge to make these choices. Healthcare providers can play a key role by addressing the environmental impact of different treatments and promoting healthy, sustainable lifestyles.

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Article Synopsis
  • Potato cultivation in Ecuador's Andes, particularly the Superchola cultivar, accounts for 60% of the country's potato production, with significant observations made from November 2022 to January 2023 related to stem lesions on these plants.
  • An investigation of symptomatic plants led to the isolation of 14 bacterial strains, with one (M3) identified as pathogenic, causing lesions on potato tubers and stems.
  • Pathogenicity tests confirmed that only isolate M3 induced disease symptoms in healthy potato plants using specific inoculation techniques.
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Introduction: Delirium, a clinical manifestation of acute encephalopathy, is associated with extended hospitalisation, long-term cognitive dysfunction, increased mortality and high healthcare costs. Despite intensive research, there is still no targeted treatment. Delirium is characterised by electroencephalography (EEG) slowing, increased relative delta power and decreased functional connectivity.

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Self-control - the ability to alter unwanted impulses and behavior to bring them into agreement with goal-driven responses - is key during adolescence. It helps young people navigate through the myriad challenges they encounter while transitioning into adulthood. We review empirical milestones in our understanding of how individual differences in adolescent self-control exist and develop.

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Background: Access to sample-level metadata is important when selecting public metagenomic sequencing datasets for reuse in new biological analyses. The Standards, Precautions, and Advances in Ancient Metagenomics community (SPAAM, https://spaam-community.org) has previously published AncientMetagenomeDir, a collection of curated and standardised sample metadata tables for metagenomic and microbial genome datasets generated from ancient samples.

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In order to meet the climate goals of the Paris Agreement and limit the potentially catastrophic consequences of climate change, we must move away from the use of fossil feedstocks for the production of chemicals and fuels. The conversion of synthesis gas (a mixture of hydrogen, carbon monoxide and/or carbon dioxide) can contribute to this. Several reactions allow to convert synthesis gas to oxygenates (such as methanol), olefins or waxes.

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Objectives: Family caregivers of persons with dementia (PwD) experience high levels of distress. We used a randomized-controlled trial to investigate the effects of telephone-based acceptance and commitment therapy (tbACT) for family caregivers.

Methods: Caregivers were randomly allocated to an intervention group (tbACT,  = 41) or an untreated control group (CG,  = 40).

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The prevalence of obesity in the Netherlands has been on the rise for decades and recent preventive efforts of government and other societal actors appear insufficient to reverse this trend. The development of food technologies neutralizing the impact of fat and sugar, and medicines that might help individuals losing weight could be seen as part of a solution. We argue however that these also reinforce three fundamental societal problems underlying the obesity crisis: a vicious market cycle, the framing of overweight as a problem of individuals, and an epistemological dilemma in science.

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Background: This study explores socioeconomic differences in acceptability and preferences for policies that aim to reduce socioeconomic health inequalities. The investigated policies range from structural policies, requiring no individual agency, to agentic policies, which depend on the individual agency for behaviour change.

Methods: An online, cross-sectional survey was conducted among 1182 participants, stratified by education and representative of Dutch adults (aged 25-65) for age and gender.

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Objective: Risk minimisation measures (RMM) are put in place to ensure safe and effective use of medicines. This study assessed whether RMM for five medicines are implemented in Dutch clinical guidelines.

Design: Descriptive study.

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Kinetic hydrate inhibitor laboratory testing before field application is one of the key priorities in the oil and gas industry. The common induction-time-based technique is often used to evaluate and screen for kinetic hydrate inhibitors (KHIs). However, the main challenge relates to the stochastic nature of hydrate nucleation observed in fresh systems, which often results in scattered data on hydrate formation with unacceptable uncertainties.

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Article Synopsis
  • - Farmers and veterinarians in the livestock sector lack sufficient information on the prevalence and impact of contagious diseases, necessitating better risk assessment tools for disease management.
  • - The DECIDE project creates data-driven decision-support tools that provide early disease signals, diagnostic options, and control strategies while considering the effects on disease spread, economic impacts, and animal welfare.
  • - By focusing on major livestock species and incorporating stakeholder needs, cost evaluations, and advanced modeling, DECIDE aims to enhance disease surveillance and decision-making, ultimately promoting a healthier and more sustainable European food chain.
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Thermal catalytic decomposition of methane is an innovative pathway to produce CO-free hydrogen from natural gas. We investigated the role of Cu content in carbon-supported bimetallic NiCu catalysts. A graphitic carbon material was used as a model support, and we combined operando methane decomposition experiments in a thermogravimetric analyzer with electron microscopy measurements.

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Visualizing the internal structure of museum objects is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of museum objects is computed tomography (CT), a technique that computationally forms a 3D image using hundreds of radiographs acquired in a full circular range. However, the lack of affordable and versatile CT equipment in museums, combined with the challenge of transporting precious collection objects, currently keeps this technique out of reach for most cultural heritage applications.

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Sensory neurons reconstruct the world from action potentials (spikes) impinging on them. To effectively transfer information about the stimulus to the next processing level, a neuron needs to be able to adapt its working range to the properties of the stimulus. Here, we focus on the intrinsic neural properties that influence information transfer in cortical neurons and how tightly their properties need to be tuned to the stimulus statistics for them to be effective.

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Background: Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding, and intervention for low self-control is, therefore, a public health goal. A prominent developmental theory proposes that individuals with high genetic propensity for low self-control that are also exposed to stressful environments may be most at-risk of low levels of self-control.

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Using a 1-year longitudinal design, we examined the role of personal demands and personal resources in long-term health impairment and motivational processes among master students. Based on the job demands-resources theory and transactional model of stress, we hypothesized that students' personal demands (i.e.

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Collaborative research in myositis-related disorders: MIHRA, a global shared community model.

Clin Exp Rheumatol

February 2024

Department of Neuromuscular Diseases and Centre for Rheumatology, University College London; and Department of Rheumatology and Queen Square Centre for Neuromuscular Diseases, University College London Hospitals NHS Foundation Trust, London, UK.

Myositis International Health and Research Collaborative Alliance (MIHRA) is a newly formed purpose-built non-profit charitable research organization dedicated to accelerating international clinical trial readiness, global professional and lay education, career development and rare disease advocacy in IIM-related disorders. In its long form, the name expresses the community's scope of engagement and intent. In its abbreviation, MIHRA, conveys linguistic roots across many languages, that reflects the IIM community's spirit with meanings such as kindness, community, goodness, and peace.

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Spontaneous Deposition of Single Platinum Atoms on Anatase TiO for Photocatalytic H Evolution.

Langmuir

March 2024

Chemistry and Structure of Novel Materials, Department of Chemistry and Biology, University of Siegen, Paul-Bonatz-Str. 9-11, 57076 Siegen, Germany.

Single-atom (SA) decoration has emerged as a frontier in catalysis due to its unique characteristics. Recently, decorated Pt single atoms on titania have shown promise in photocatalytic hydrogen evolution. In this work, we demonstrate that Pt SAs can spontaneously deposit on the surface, driven by electrostatic forces; the key is to determine the golden pH and surface potential.

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[What can you do to … not be influenced?].

Ned Tijdschr Geneeskd

December 2023

Universiteit Utrecht, Utrecht InstituteforPharmaceutical Sciences (UIPS), afd. Farmaco-epidemiologie & Klinische Farmacologie, Utrecht.

Objectives: To identify persuasion strategies in paper-based marketing materials about medicines, sent to general practices.

Design: Observational study.

Method: Twenty Dutch general practices collected all mail from pharmaceutical companies during one month.

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Implementing co-created citizen science in five environmental epidemiological studies in the CitieS-Health project.

Environ Res

January 2024

Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

Article Synopsis
  • Scientists are trying to get more people involved in research to improve the way science connects with communities, especially in understanding how the environment affects our health.
  • The CitieS-Health project allowed regular citizens in five European countries to work together with scientists on important health studies about things like air pollution and mental health.
  • Citizens played a big role in all parts of these studies, from coming up with ideas to sharing the results, but the scientists faced challenges in making sure everyone understood complex topics and balancing different opinions.
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In March 2018, the European pregnancy prevention programme for oral retinoids was updated as part of risk minimisation measures (RMM), emphasising their contraindication in pregnant women. To measure the impact of the 2018 revision of the RMMs in Europe by assessing the utilisation patterns of isotretinoin, alitretinoin and acitretin, contraceptive measures, pregnancy testing, discontinuation, and pregnancy occurrence concomitantly with a retinoid prescription. An interrupted time series (ITS) analysis to compare level and trend changes after the risk minimisation measures implementation was conducted on a cohort of females of childbearing age (12-55 years of age) from January 2010 to December 2020, derived from six electronic health data sources in four countries: Denmark, Netherlands, Spain, and Italy.

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Eighteenth century river hydraulics used both theory and measurement to address problems of flood safety, navigation and defense related to the rivers. In the late eighteenth century the Dutch overseer of the rivers, Christiaan Brunings, integrated hydraulic theory and meteorological practices, which enabled him to design a unique instrument for measuring river flow. The question is whether the unprecedented detail of measurements fits the putative empirical stance in the eighteenth century.

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