The COSMOS Registry of CytoSorb Hemoadsorption Therapy in Critically Ill Patients: Protocol for an International, Prospective Registry.

Background: Extracorporeal blood purification with CytoSorb has been increasingly used as an adjunctive therapy in several hyperinflammatory critical care conditions, as well as to remove elevated levels of myoglobin or bilirubin in patients with rhabdomyolysis or liver failure. Despite the increasing worldwide use of hemoadsorption, data from large international multicenter studies are still lacking.

Objective: The COSMOS (CytoSorb Treatment Of Critically Ill Patients) registry is a company-sponsored registry by CytoSorbents Corporation and CytoSorbents Medical Inc.

Metallic-based phthalocyanine nanoemulsions for photodynamic purging of ovarian tissue in leukemia patients.

For cancer patients with a high risk of ovarian tissue metastasis, ovarian autotransplantation is not advised due to the potential spread of malignant cells. Ex vivo purging of ovarian fragments may offer a more suitable alternative for fertility restoration. Eradicating malignant cells should be done selectively without affecting follicles or ovarian stromal cells (SCs).

Platelet Membrane-Camouflaged Copper Doped CaO Biomimetic Nanomedicines for Breast Cancer Combination Treatment.

Breast cancer (BC) is the most frequently diagnosed cancer in women worldwide. Chemodynamic therapy (CDT), photothermal therapy (PTT), and ion interference therapy (IIT), used in combination, represent a common treatment. In this study, platelet membrane-camouflaged copper-doped CaO biomimetic nanomedicines have been developed for breast cancer treatments.

[Non-small cell lung cancer in adults under 40 years of age].

Introduction: Non-small cell lung cancers (NSCLC) are the most common lung cancers, withpeak incidence at 65years of age. These cancers rarely occur before the age of 40.

Methods: Based on an illustrative clinical case, a systematic review of the literature was conducted to study the epidemiological, clinical, histological, and biological characteristics of NSCLC in adults under 40years of age.

Automated segmentation in planning-CT for breast cancer radiotherapy: A review of recent advances.

Postoperative radiotherapy (RT) has been shown to effectively reduce disease recurrence and mortality in breast cancer (BC) treatment. A critical step in the planning workflow is the accurate delineation of clinical target volumes (CTV) and organs-at-risk (OAR). This literature review evaluates recent advancements in deep-learning (DL) and atlas-based auto-contouring techniques for CTVs and OARs in BC planning-CT images for RT.

Community antibiotic consumption in the European Union/European economic area: late-pandemic rebound and seasonality analysis.

Background: A rebound in antibiotic consumption has been observed in the European community at the end of the COVID-19 pandemic. Here we evaluate the extent of this increase, when it exactly occurred, and how the seasonality in antibiotic use changed during the late-pandemic period.

Methods: Data on community antibiotic consumption were available from the European Surveillance of Antimicrobial Consumption Network for 28 European countries between 2015 and 2022.

Cluster analysis identifies long COVID subtypes in Belgian patients.

Severe acute respiratory syndrome coronavirus infection presents complications known as long COVID, a multisystemic organ disease which allows multidimensional analysis. This study aims to uncover clusters of long COVID cases and establish their correlation with the clinical classification developed at the Clinical Research Unit of Brugmann University Hospital, Brussels. Such an endeavour is instrumental in customizing patient management strategies tailored to the unique needs of each distinct group.

A Satellite-Based Indicator for Diagnosing Particulate Nitrate Sensitivity to Precursor Emissions: Application to East Asia, Europe, and North America.

Particulate nitrate is a major component of fine particulate matter (PM) and a key target for improving air quality. Its formation is varyingly sensitive to emissions of nitrogen oxides (NO ≡ NO + NO), ammonia (NH), and volatile organic compounds (VOCs). Diagnosing the dominant sensitivity is critical for effective pollution control.

Genetic and functional diversity of allorecognition receptors in the urochordate, .

Allorecognition in is controlled by a highly polymorphic locus (the ), and functionally similar to missing-self recognition utilized by Natural Killer cells-compatibility is determined by sharing a self-allele, and integration of activating and inhibitory signals determines outcome. We had found these signals were generated by two -encoded receptors, called and Here we show that genes are members of an extended family consisting of >37 loci, and co-expressed with an even more diverse gene family-the (). The are membrane proteins related to , but include conserved tyrosine motifs, including ITIMs and hemITAMs.

Modelling the cost differential between current and healthy diets according to household education level in Belgium.

This study aims to estimate the cost differential between current and healthy diets, overall and by household education level. Data from the 2014-2015 and food prices from the 2014 were linked. The was used to model healthy, isocaloric healthy and current diets.

Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan.

Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin as crosslinker. The synthesis of HACC and CHS-DA was effectively confirmed using Fourier transform infrared (FT-IR) analysis and H nuclear magnetic resonance (H NMR) spectroscopy.

Prosthetic Joint Infection: Case Report and a Review of the Literature.

Prosthetic joint infections caused by are uncommon, with the majority of cases being attributed to . This case report represents the third instance of a prosthetic hip infection caused by following an episode of gastroenteritis and, notably, in an immunocompetent patient. The infection was successfully managed by surgical debridement and lavage with retention of the prosthesis and 12 weeks of antibiotics.

Froin's Syndrome: A Comprehensive Review of the Literature and the Addition of Two New Cases.

Background: Froin's syndrome (FS) is a rare entity with uncertain prevalence and prognosis, defined by a pathognomonic triad: cerebrospinal fluid (CSF) xanthochromia, elevated protein levels in the CSF, and hypercoagulated CSF, usually obtained through lumbar puncturing below the level of a partial or complete spinal block.

Methods: We conducted a comprehensive review of the literature on FS from its first description in 1903 to December 2023, utilizing PubMed and Google Scholar, and included two new cases from our clinical practice.

Results: We describe two patients who suffered from Froin's syndrome secondary to spinal abscesses.

Impact of Comorbid Personality Disorder on the Risk of Involuntary Hospitalization in Patients Referred for Urgent Forensic Assessment: A Cross-Sectional Study.

Background/objectives: In Belgium, involuntary psychiatric hospitalization is authorized in the presence of certain criteria governed by the law relating to the protection of the mentally ill. The number of involuntary hospitalizations has been increasing continuously in recent years. Since personality disorders are frequent comorbidities in involuntarily hospitalized patients, the aim of this study was to investigate the potential role played by comorbid personality disorders in the decisions about involuntary hospitalization made during urgent forensic assessment.

Sleep Fragmentation Modulates the Neurophysiological Correlates of Cognitive Fatigue.

Cognitive fatigue (CF) is a critical factor affecting performance and well-being. It can be altered in suboptimal sleep quality conditions, e.g.

Pleuropulmonary Epithelioid Hemangioendothelioma.

We present the CT, thoracoscopic, and histological findings of a 55-year-old female with pleuropulmonary epithelioid hemangioendothelioma. The CT scan revealed pleuropulmonary lesions, and thoracoscopy allowed direct visualization and biopsy of the lesions. Histological analysis confirmed the diagnosis, emphasizing the utility of combining imaging, endoscopic, and pathological methods in diagnosing this rare tumor.

The neurophysiological effects of detached and positive reappraisal during the regulation of self-conscious emotions.

Background: While cognitive reappraisal represents a promising emotion regulation strategy in regulating basic emotions, little experimental research has investigated its efficacy in reducing self-conscious emotions such as shame and guilt.

Objective: The present study aimed to investigate the effectiveness of detached reappraisal and positive reappraisal in regulating feelings of shame and guilt, and also compared the effectiveness of these two strategies using behavioral and event-related potentials.

Method: Thirty-nine participants grouped either in positive reappraisal or detached reappraisal condition were informed to advise the decider to perform a dot-estimation task.

Fabrication of injectable, adhesive, self-healing, superabsorbent hydrogels based on quaternary ammonium chitosan and oxidized pullulan.

Injectable hydrogels, which are polymeric materials that are characterized by their ability to be injected in a liquid form into cavities and subsequently undergo in situ solidification, have garnered significant attention. These materials are extensively used in a range of biomedical applications. This study synthesized several injectable composite hydrogels through the mild Schiff base reaction while imposing different concentrations of quaternary ammonium chitosan and oxidized pullulan.

General practitioners' views on inappropriate prescribing for older patients: a qualitative study through focus groups.

Background: Inappropriate prescribing (IP) is a common problem in the older population. Despite numerous attempts to tackle this issue, it remains a public health concern. In most European countries, general practitioners (GPs) are responsible for global primary care and are thus gatekeepers for the adequacy of medicines, specifically for older people.

Pregnancy-related hormonal changes and thyroid growth: do they have an impact on the higher incidence of differentiated thyroid cancer in women?

Purpose Of Review: To analyze whether pregnancy could play a role in the higher prevalence of differentiated thyroid carcinoma (DTC) in women. Estrogens strongly modify thyroid economy by increasing iodine clearance, thyroid hormone requirement and production. Human chorionic gonadotropin (hCG) contributes to the increased thyroid hormone synthesis.

Reproductive life and differentiated thyroid carcinoma in women: reciprocal influences on their respective outcome.

Purpose Of Review: To analyze the reciprocal influences between female reproductive life and DTC management.

Recent Findings: Data on pregnancy outcome in DTC patients indicate that after conceiving, these women may need an increased L-T4 dose to maintain suppressed serum TSH levels. Nevertheless, this does not determine major harm in terms of pregnancy outcome.