4,126 results match your criteria: "Universite libre de Bruxelles ULB[Affiliation]"
Leuk Res Rep
December 2024
Internal Medicine Department, Institut Jules Bordet - Hôpital Universitaire de Bruxelles (H.U.B.), Université Libre de Bruxelles (ULB), Brussels, Belgium.
We describe the case of a female patient with May-Hegglin syndrome who developed peripheral T-cell lymphoma not otherwise specified. The patient presents with systemic lupus erythematous phenotype and myelofibrosis secondary to T-cell lymphoma. Peripheral T-cell lymphoma not otherwise specified, represents 25 % of all peripheral T-cell lymphoma.
View Article and Find Full Text PDFBMC Biol
January 2025
Faculty of Sciences, Centre for Environmental Sciences, Research Group Zoology: Biodiversity and Toxicology, UHasselt - Hasselt University, Diepenbeek, Belgium.
Background: Stress responses are key the survival of parasites and, consequently, also the evolutionary success of these organisms. Despite this importance, our understanding of the evolution of molecular pathways dealing with environmental stressors in parasitic animals remains limited. Here, we tested the link between adaptive evolution of parasite stress response genes and their ecological diversity and species richness.
View Article and Find Full Text PDFLancet
January 2025
Internal Medicine Department, Delta Hospital, CHIREC & Université Libre de Bruxelles, Brussels, Belgium.
Sleep
January 2025
UR2NF-Neuropsychology and Functional Neuroimaging Research Unit affiliated at CRCN - Centre for Research in Cognition and Neurosciences and UNI - ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Enhancing the retention of recent memory traces through sleep reactivation is possible via Targeted Memory Reactivation (TMR), involving cueing learned material during post-training sleep. Evidence indicates detectable short-term microstructural changes in the brain within an hour after motor sequence learning, and post-training sleep is believed to contribute to the consolidation of these motor memories, potentially leading to enduring microstructural changes. In this study, we explored how TMR during post-training sleep affects performance gains and delayed microstructural remodeling, using both standard Diffusion Tensor Imaging (DTI) and advanced Neurite Orientation Dispersion & Density Imaging (NODDI).
View Article and Find Full Text PDFCells
December 2024
Radiotherapy Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Definitive chemoradiotherapy (CRT) is a cornerstone of treatment for locoregionally advanced head and neck cancer (HNC). Research is ongoing on how to improve the tumor response to treatment and limit normal tissue toxicity. A major limitation in that regard is the growing occurrence of intrinsic or acquired treatment resistance in advanced cases.
View Article and Find Full Text PDFCreat Nurs
January 2025
Society and Ageing Research Lab, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Educational programs for health-care providers increasingly implement culturally sensitive care. Clear methods for educating students in cultural awareness are still lacking. Research indicates that simply increasing knowledge on ethnicity, culture, or migration does not improve culturally sensitive behavior and can foster stereotypes.
View Article and Find Full Text PDFTransfusion
January 2025
Blood Bank - Laboratory of Immunohematology, Centre Hospitalier Universitaire Brugmann/Université Libre de Bruxelles (ULB), Brussels, Belgium.
Background: Detection of alloantibodies associated with the JK system may be tricky. They are nevertheless associated with transfusion reactions and their detection is crucial.
Study Design And Methods: Retrospectively and over a period of 7 years, we compared the results obtained using two different assays for antibody detection.
Nat Commun
January 2025
State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.
Intensified host-guest electronic interplay within stable metal-organic cages (MOCs) presents great opportunities for applications in stimuli response and photocatalysis. Zr-MOCs represent a type of robust discrete hosts for such a design, but their host-guest chemistry in solution is hampered by the limited solubility. Here, by using pyridinium-derived cationic ligands with tetrakis(3,5-bis(trifluoromethyl)phenyl)borate (BAr) as solubilizing counteranions, we report the preparation of soluble Zr-MOCs of different shapes (1-4) that are otherwise inaccessible through a conventional method.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Cellular and Molecular Biology, Lahijan Branch, Islamic Azad University, Lahijan, Iran.
Background/aims: Gastric cancer (GC) is a significant global health issue with high incidence rates and poor prognoses, ranking among the top prevalent cancers worldwide. Due to undesirable side effects and drug resistance, there is a pressing need for the development of novel therapeutic strategies. Understanding the interconnectedness of the JAK2/STAT3/mTOR/PI3K pathway in tumorigenesis and the role of Astaxanthin (ASX), a red ketocarotenoid member of xanthophylls and potent antioxidant and anti-tumor activity, can be effective for cancer treatments.
View Article and Find Full Text PDFNat Commun
January 2025
Institut Pasteur, Université Paris Cité, CNRS UMR3525, Unité Plasticité du Génome Bactérien, Département Génomes et Génétique, Paris, France.
The replication of the two chromosomes in the pathogenic bacterium Vibrio cholerae is coordinated by the binding of initiator protein RctB to a checkpoint sequence, crtS. Replication of crtS on the primary chromosome (Chr1) triggers replication of the secondary chromosome (Chr2), but the details are poorly understood. Here, we analyze RctB binding patterns in the V.
View Article and Find Full Text PDFPhysiol Rep
January 2025
Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Bruxelles, Belgium.
The effect of acetazolamide on regional brain tissue oxygenation in patients with acute brain injury (ABI) is unknown. We studied adult patients with ABI who received acetazolamide as per the treating physician's decision and had ICP and brain oxygen pressure (PbtO) monitoring. Baseline measurements of ICP, cerebral perfusion pressure (CPP), and PbtO were taken before administering acetazolamide; subsequent measurements were recorded every 5 min for a total of 20 min.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Hidradenitis suppurativa is an inflammatory skin disease for which adalimumab is an effective treatment in just over half of cases. Few factors associated with therapeutic response, and therefore potentially predictive of response, are known to date. This real-life study retrospectively explores the existence of such factors in a Belgian cohort of 82 patients, using several response scores: the Hidradenitis Suppurativa Clinical Response (HiSCR), the International Hidradenitis Suppurativa Severity Scoring System-55 (iHS4-55), and the dynamic metascore (a combination of the Hurley score, the 2007 version of the Sartorius score, the iHS4 and the HiSCR).
View Article and Find Full Text PDFInt J Surg Case Rep
December 2024
Bibliothèque des Sciences de la Santé, Université libre de Bruxelles (ULB), Campus Erasme - CP 607, Route de Lennik, 808, 1070 Bruxelles, Belgium. Electronic address:
Introduction: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common type of cancer in the world. Metastases occur in up to 40 % of cases and bones are the second most frequent site. Metastases in extremities are uncommon with very few publications covering distal lower-limb bone metastasis.
View Article and Find Full Text PDFWhile pancreatic beta-cell proliferation has been extensively studied, the role of cell death during islet development remains incompletely understood. Using a genetic model of caspase inhibition in beta cells coupled with mathematical modeling, we here discover an onset of beta-cell death in juvenile zebrafish, which regulates beta-cell mass. Histologically, this beta-cell death is underestimated due to phagocytosis by resident macrophages.
View Article and Find Full Text PDFCerebellum
January 2025
Center for Language and Cognition, University of Groningen, PO box 716, 9700 AS, Groningen, the Netherlands.
Pediatric cerebellar tumor survivors may present with spontaneous language impairments following treatment, but the nature of these impairments is still largely unclear. A recent study by Svaldi et al. (Cerebellum.
View Article and Find Full Text PDFACS Omega
December 2024
Laboratoire de Chimie Organique, Service de Chimie et PhysicoChimie Organiques, Université libre de Bruxelles (ULB), Avenue F. D. Roosevelt 50, CP160/06, Brussels 1050, Belgium.
An in-depth experimental and computational study to rationalize the mechanism underlying the gold-catalyzed intramolecular hydroalkylation of ynamides to indenes is reported. Evaluating the reactivity of a set of deuterated ynamides and gold complexes allowed to get valuable insights into the mechanism of this reaction, while DFT calculations allowed to determine a plausible reaction pathway for this unprecedented transformation. This pathway involves the activation of the ynamide followed by a [1,5]-hydride shift from the highly reactive, in situ generated keteniminium ion, and a subsequent cyclization before deprotonation followed by a final protodeauration.
View Article and Find Full Text PDFClin Infect Dis
January 2025
ISARIC - Pandemic Sciences Institute, University of Oxford, United Kingdom.
Background: The global mpox outbreak which started in May 2022 was caused by a novel clade IIb variant of the mpox virus (MPXV). It differed from the traditional Western and Central Africa disease in transmission patterns and clinical presentation.
Methods: To address the need for detailed clinical and virologic data, we conducted an observational cohort study (MOSAIC) during May 2022-July 2023 in individuals with confirmed MPXV infection enrolled in six European Countries.
J Adv Nurs
January 2025
Department of Health Services and Management, School of Medical Humanities and Management, Wenzhou Medical University, Wenzhou, China.
Aim: To explore changes in home- and community-based service utilisation and its associated factors among Chinese older adults between 2016 and 2018.
Design: A national cohort study.
Methods: This study included 6924 older adults from the China Longitudinal Aging Social Survey 2016 and 2018 waves, examining the changes in service utilisation among four groups: continuous users, former users, new users and nonusers.
Radiography (Lond)
December 2024
Université Libre de Bruxelles (ULB), Brussels University Hospital, Jules Bordet Institute, Radiotherapy Department, Rue Meylemeersch 90, 1070 Bruxelles, Belgium.
Introduction: Radiation Therapists (RTTs) are crucial in delivering Radiotherapy (RT) to cancer patients. The advancements in RT technology and the increasing cancer incidence have heightened the demand for RTTs, necessitating strategic workforce planning at the national level. This study aims to identify and estimate current and future RTT workforce in Belgium.
View Article and Find Full Text PDFHealth Expect
February 2025
Osteopathy Sciences Research Unit (URSO), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Objective: Chronic musculoskeletal pain (CMSP) is frequent in chronic diseases, decreasing the quality of life of these patients. In a survey conducted in Belgium in 2019, chronic pain was named by patients as the main factor of complexity in their lives. The objective of our research was to provide elements to understand why and how CMSP contributes to the complexity of these people's lives.
View Article and Find Full Text PDFInt J Cancer
December 2024
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) is a dNTP hydrolase important for intracellular dNTP homeostasis and serves as tumor suppressor and modulator of antimetabolite efficacy in cancer, though largely unexplored in breast cancer (BC). A cohort of patients with early BC (n = 564) with available gene expression data (GEP) was used. SAMHD1 protein expression was assessed by immunohistochemistry performed on tissue microarrays.
View Article and Find Full Text PDFJ Funct Morphol Kinesiol
December 2024
Environmental, Occupational, Aging (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), 1160 Brussels, Belgium.
This study investigates the effects of a five-week training program on the medial gastrocnemius muscle, comparing two approaches: blood flow restriction (BFR) training and normobaric hyperoxia (oxygen supplementation). It evaluates three strengthening modalities (dynamic, isometric, and the 3/7 method) analyzing their impact on maximal voluntary contraction (MVC), muscle architecture, and perceived exertion. A total of 36 young healthy participants (21 females, 15 males) were randomized into six subgroups (n = 6 each) based on the type of contraction and oxygen condition.
View Article and Find Full Text PDFCurr Oncol
December 2024
Department of Digestive Surgery and Digestive Surgical Oncology, Jules Bordet Institute, The Brussels University Hospital (H.U.B), Université Libre de Bruxelles (ULB), Meylemeersch Street 90, 1070 Brussels, Belgium.
Ovarian cancer (OC) is diagnosed at a locally advanced stage in two-thirds of cases. The first line of treatment consists of cytoreductive surgery (CRS) combined with neoadjuvant and/or adjuvant chemotherapy. However, CRS can be associated with high rates of postoperative complications (POCs), and detection of fragile patients at high risk of POCs is important.
View Article and Find Full Text PDFClocks Sleep
December 2024
UR2NF-Neuropsychology and Functional Neuroimaging Research Unit, at CRCN-Centre for Research in Cognition and Neurosciences and UNI-ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium.
Continued solicitation of cognitive resources eventually leads to cognitive fatigue (CF), i.e., a decrease in cognitive efficiency that develops during sustained cognitive demands in conditions of constrained processing time, independently of sleepiness.
View Article and Find Full Text PDFAdv Mater
December 2024
Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, CB3 0HE, UK.
High contact resistance remains the primary obstacle that hinders further advancements of organic semiconductors (OSCs) in electronic circuits. While significant effort has been directed toward lowering the energy barrier at OSC/metal contact interfaces, approaches toward reducing another major contributor to overall contact resistance - the bulk resistance - have been limited to minimizing the thickness of OSC films. However, the out-of-plane conductivity of OSCs, a critical aspect of bulk resistance, has largely remained unaddressed.
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