2,503 results match your criteria: "Universite de Reims Champagne-Ardenne[Affiliation]"

Article Synopsis
  • The study investigates the link between blood eosinophil count (BEC) and airway microbiota in stable COPD patients.
  • It involved 59 adult patients, categorized into low BEC (<300/mm) and high BEC (≥300/mm) groups, assessing clinical features and microbiota.
  • Results showed that patients with high BEC experienced more frequent exacerbations and worse symptoms, but microbiota composition was similar across both groups.
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[Eosinophilic fasciitis: From pathophysiology to therapeutics].

Rev Med Interne

August 2024

Service de médecine interne, maladie infectieuse et immunologie clinique, hôpital Robert-Debré, CHU de Reims, rue du Général-Kœnig, 51092 Reims cedex, France; EA 7509 IRMAIC, université de Reims Champagne-Ardenne, Reims, France. Electronic address:

Article Synopsis
  • Eosinophilic fasciitis (EF) is a rare connective tissue disorder that leads to painful swelling and hardening of skin on limbs and trunk, causing joint pain and limited movement.
  • Over 300 cases have been documented since its first identification in 1974, with diagnosis typically confirmed through a deep skin biopsy showing specific tissue changes.
  • Current treatments primarily involve corticosteroids, sometimes with additional medications like methotrexate, while there are emerging therapies targeting interleukin-6 that may offer promising results.
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This study was conducted in Bejaia, Algeria, to determine the presence of in fresh watermelon ( = 105), soil ( = 23), and irrigation water samples ( = 17) collected from two different farms. After isolation, antimicrobial susceptibility testing, serotype determination, multilocus sequence typing, antimicrobial resistance genes detection, and whole genome sequencing were performed. Twenty watermelon samples (19%) were contaminated with , but none were found in the soil or irrigation water.

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Serum S100B Level in the Management of Pediatric Minor Head Trauma: A Randomized Clinical Trial.

JAMA Netw Open

March 2024

Department of Biochemistry and Molecular Genetics, Centre Hospitalier Universitaire (CHU) Clermont-Ferrand, Université Clermont Auvergne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique, Reproduction et Développement, Clermont-Ferrand, France.

Importance: Minor head trauma (HT) is one of the most common causes of hospitalization in children. A diagnostic test could prevent unnecessary hospitalizations and cranial computed tomographic (CCT) scans.

Objective: To evaluate the effectiveness of serum S100B values in reducing exposure to CCT scans and in-hospital observation in children with minor HT.

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Structural and physical basis for the elasticity of elastin.

Q Rev Biophys

March 2024

UMR URCA/CNRS 7369, Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR Sciences Exactes et Naturelles, SFR CAP Santé, Université de Reims Champagne-Ardenne, Reims, France.

Elastin function is to endow vertebrate tissues with elasticity so that they can adapt to local mechanical constraints. The hydrophobicity and insolubility of the mature elastin polymer have hampered studies of its molecular organisation and structure-elasticity relationships. Nevertheless, a growing number of studies from a broad range of disciplines have provided invaluable insights, and several structural models of elastin have been proposed.

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Structural impact of a new spike Y170W mutation detected in early emerging SARS-CoV-2 Omicron variants in France.

Virus Res

May 2024

University of Reims Champagne-Ardenne, Laboratory of Virology, CardioVir UMR-S 1320 51 rue Cognacq Jay, REIMS Cedex, Reims 51092, France; Virology Department, CHU Reims, Hôpital Robert Debré, Reims, France.

Article Synopsis
  • A study analyzed 150 nasopharyngeal samples from outpatient cases in northeastern France during the emergence of the SARS-CoV-2 Omicron variant in December 2021, finding that only 3 samples (2%) were Omicron variants while 147 (98%) were delta variants.
  • Phylogenetic analysis suggested that the early Omicron strains might have originated from South Africa or India, and an uncharacterized spike mutation (Y170W) was identified, which was weakly present during this period.
  • The study concluded that a routine whole-genome sequencing approach is crucial for understanding and tracking the genotypic changes of SARS-CoV-2 variants, which could inform public health policies.
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Exploration of the Diversity of Vicine and Convicine Derivatives in Faba Bean ( L.) Cultivars: Insights from LC-MS/MS Spectra.

Molecules

February 2024

Biotechnologies and Environmental Analytics Platform (BEAP), Environmental Research and Innovation Department (ERIN), Luxembourg Institute of Science and Technology (LIST), 5, Rue Bommel, L-4940 Hautcharage, Luxembourg.

Article Synopsis
  • * Breeding efforts for faba beans focus on lowering these toxic alkaloids to improve safety, yet current methods only measure vicine and convicine, ignoring their potentially harmful derivatives.
  • * Recent research identified over a hundred derivatives of (con)vicine in faba bean cultivars, suggesting that the bioactive content might be underestimated and indicating a need for more comprehensive studies on these compounds.
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Background: Drug research is a long process, taking more than 10 years and requiring considerable financial resources. Therefore, researchers and industrials aim to reduce time and cost. Thus, they use computational simulations like molecular docking to explore huge databases of compounds and extract the most promising ones for further tests.

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The walking dead: Are Zombie firms environmentally and socially responsible? A global perspective.

J Environ Manage

March 2024

South Champagne Business School, Y Schools, Troyes, France; INTRARE, Université de Reims Champagne Ardenne, Reims, France; Department of Business Administration, Iqra University, Karachi, Pakistan. Electronic address:

This study examines the association between zombie firms and their environmental and social performance. Using a global dataset of listed firms from 49 countries between 2002 and 2019, we find that zombie firms perform poorly on environmental and social responsibility fronts. This finding supports the argument that zombie firms are characterized by consistent losses and that their existence is risky without external support.

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Thrombotic microangiopathies (TMA) are usually associated with hematological features (RH-TMA). The epidemiology of TMA limited to kidneys (RL-TMA) is unclear Therefore, patients with TMA and native kidney biopsies were identified during 2009-2022 in 20 French hospitals and results evaluated. RL-TMA was present in 341/757 (45%) patients and associated with lower creatinine levels (median 184 vs 346 μmol/L) than RH-TMA.

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Background And Objectives: This research relies on a combination of variable- and person-centered approaches to help improve our understanding of the dimensionality of job demands by jointly considering employees' global levels of job demands, exposure and their specific levels of exposure to challenge and hindrance demands.

Design And Methods: We relied on a sample of 442 workers who completed a questionnaire twice over three months. Our analyses sought to identify the nature of the job demands profiles experienced by these workers, to document the stability of these profiles over time, and to assess their associations with theoretically-relevant outcomes (i.

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Major challenge in biorefineries is the use of all lignocellulosic components, particularly lignins. In this study, Thermobacillus xylanilyliticus grew on kraft lignin, steam-exploded and native wheat straws produced different sets of phenoloxidases and xylanases, according to the substrate. After growth, limited lignin structural modifications, mainly accompanied by a decrease in phenolic acids was observed by Nuclear Magnetic Resonance spectroscopy.

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Individuals with psychotic disorders such as schizophrenia may be more vulnerable during pandemics, but research on this topic is limited. This study examined COVID-19 impact on a population affected by schizophrenia during the COVID-19 pandemic. Levels of psychological distress and COVID-19-related behaviours, from the COVID-related Thoughts and Behavioral Symptoms (Cov-Tabs) Scale, were compared between 107 patients with schizophrenia and 70 control participants.

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UVC Box: An Effective Way to Quickly Decontaminate Healthcare Facilities' Wheelchairs.

Life (Basel)

February 2024

Université de Reims Champagne-Ardenne, UR 4691 Biomatériaux et Inflammation en Site Osseux (BIOS), UFR de Pharmacie, SFR CAP-Santé, 51 rue Cognacq Jay, 51100 Reims, France.

Disinfection in the hospital environment remains challenging, especially for wide and structurally complex objects such as beds or wheelchairs. Indeed, the regular disinfection of these objects with chemicals is manually carried out by healthcare workers and is fastidious and time-consuming. Alternative antibacterial techniques were thus proposed in the past decades, including the use of naturally antimicrobial UVC.

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Article Synopsis
  • The insulin receptor (IR) is crucial for insulin signaling, and defects in its function are linked to type 2 diabetes.
  • This study explores how the removal of sialic acid from N-glycan chains of the IR affects its function, particularly in 3T3-L1 adipocytes.
  • Findings show that desialylation reduces the autophosphorylation activity of the IR and weakens its ability to interact with insulin, potentially contributing to insulin resistance in diabetes.
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The data provided here relate to the research paper "Assessing the complementarity of TD-NMR, solid-state NMR and Dynamic Vapor Sorption in the characterization of polysaccharide-water interactions". The original data from TD-NMR, ss-NMR and DVS is provided in .dps, topspin and .

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Background: Extracellular matrices play a critical role in tissue structure and function and aberrant remodelling of these matrices is a hallmark of many age-related diseases. In skin, loss of dermal collagens and disorganization of elastic fibre components are key features of photoageing. Although the application of some small matrix-derived peptides to aged skin has been shown to beneficially affect in vitro cell behaviour and, in vivo, molecular architecture and clinical appearance, the discovery of new peptides has lacked a guiding hypothesis.

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Background: The HOME-CoV (Hospitalisation or Outpatient ManagEment of patients with SARS-CoV-2 infection) score is a validated list of uniquely clinical criteria indicating which patients with probable or proven COVID-19 can be treated at home. The aim of this study was to optimise the score to improve its ability to discriminate between patients who do and do not need admission.

Methods: A revised HOME-CoV score was derived using data from a previous prospective multicentre study which evaluated the original Home-CoV score.

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Article Synopsis
  • In 2019, France expanded its HPV vaccination recommendations to include boys aged 11 to 19, prompting a study on how French general practitioners (GPs) adapted their vaccination practices following this change.
  • A cross-sectional survey conducted between May and August 2022 revealed that 61.2% of participating GPs now systematically offer HPV vaccination to boys, compared to just 5.5% before the recommendation.
  • Factors influencing this increase included the gender of the GP, with female GPs more likely to advocate for vaccination, and prior experience in proposing the vaccine before the official recommendation.
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Infections Differ Among Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Individuals: Results From a Nationwide Surveillance Program in France.

Open Forum Infect Dis

February 2024

Department of Infectious Diseases and Tropical Medicine, Université Paris Cité, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Institut Hospitalo-Universitaire Imagine, Paris, France.

Among 1107 cryptococcosis cases from the French surveillance network (2005-2020), the proportion of HIV-seronegative individuals has recently surpassed that of HIV-seropositive individuals. We observed marked differences in patient characteristics, disease presentations, cryptococcal antigen results, infecting species, and mortality according to HIV serostatus.

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Plant-growth-promoting rhizobacteria (PGPR) could potentially enhance photosynthesis and benefit plant growth by improving soil nutrient uptake and affecting plant hormone balance. Several recent studies have unveiled a correlation between alterations in photosynthesis and host plant resistance levels. Photosynthesis provides materials and energy for plant growth and immune defense and affects defense-related signaling pathways.

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