Biotransformation of anabolic androgenic steroids in human skin cells.

In comparison to well-known drug-metabolizing organs such as the liver, the metabolic capacity of human skin is still not well elucidated despite the widespread use of topical drug application. To gain a comprehensive insight into anabolic steroid metabolism in the skin, six structurally related anabolic androgenic steroids, testosterone, metandienone, methyltestosterone, clostebol, dehydrochloromethyltestosterone, and methylclostebol, were applied to human keratinocytes and fibroblasts derived from the juvenile foreskin. Phase I metabolites obtained from incubation media were analyzed by gas chromatography-mass spectrometry.

Are cannabis use problems comparable across individuals using for recreational and medical purposes? An international cross-sectional study of individuals who use self-grown cannabis.

Background: Little is known about cannabis use problems among individuals who use cannabis for medical purposes and whether rates and determinants of cannabis use problems in medical users differ to those observed among individuals using for recreational reasons. This study examines whether Severity of Dependence Scale (SDS) scores differ across individuals who use self-grown cannabis for the following reasons: "recreational only", "medical and recreational" and "medical only". Furthermore, the study tests whether cannabis use frequency, cannabis strain, and type of cannabis influences the strength of the association between purpose of use and cannabis use problems.

The systemic error in the vertical component of handgun bullet trajectory reconstructions.

Establishing the path or trajectory of a fired bullet is an often recurring part of shooting incident reconstruction. The current study describes how gravitational pull causes a systemic error on the vertical component of a trajectory reconstruction. Bullet drop, drop angle, and vertical offset are explained and calculated for 10 different handgun/ammunition combinations over a range of distances up to 100 m.

Research- vs. government-driven physical activity policy monitoring: a systematic review across different levels of government.

Background: Even though the importance of physical activity policy monitoring has increased in the last decade, there is a lack of understanding what different approaches exist and which methodology they employ. In order to address this research gap, this review attempts to map existing approaches of physical activity policy monitoring and to analyse methodological aspects, especially with regards to the roles of governments and researchers.

Methods: A systematic search was conducted in five scientific databases (PubMed, Scopus, SportDiscus, Psycinfo, Web of Knowledge) in July 2021, and the identified records were screened independently by two reviewers.

A new temporal framework for the passionate engagement journey of ultra-endurance athletes: A qualitative investigation.

The explosion of popularity of ultra-endurance (UE) sports in the last 20 years has attracted a lot of interest amongst sport psychologists who studied many aspects of their participants. However, a temporal perspective on the development of the UE engagement was missing. With this research we aimed to explore the long-term individual journeys of UE athletes and how their passion developed over time from the moment of inception to full adoption of UE as an identity and a lifestyle.

[Towards eco-responsible medical devices : life cycle analysis of medicine cups].

Human Health relies on Environmental Health, we thus must assess the environmental impact of healthcare systems. Life cycle analysis (LCA) quantifies the impacts on : human health, climate change, ecosystems and resources. This technique allows for evaluation of the environmental impacts of objects or processes.

Consensus definition of advance care planning in dementia: A 33-country Delphi study.

Introduction: Existing advance care planning (ACP) definitional frameworks apply to individuals with decision-making capacity. We aimed to conceptualize ACP for dementia in terms of its definition and issues that deserve particular attention.

Methods: Delphi study with phases: (A) adaptation of a generic ACP framework by a task force of the European Association for Palliative Care (EAPC); (B) four online surveys by 107 experts from 33 countries, September 2021 to June 2022; (C) approval by the EAPC board.

[Recognizing and managing side effects of tyrosine kinase inhibitors in chronic myeloid leukemia].

Tyrosine kinase inhibitors (TKI) have emerged as a paradigm-shifting therapeutic approach for the treatment of chronic myeloid leukemia (CML) following their regulatory approval in 2001. These agents have revolutionized the management of CML by significantly improving patient outcomes and enabling them to achieve near-normal life expectancies. Consequently, the utilization of TKI has become increasingly prevalent, accompanied by the recognition and management of their associated adverse effects.

French validation of the Compensatory Eating and Behaviors in Response to Alcohol Consumption Scale (CEBRACS) in a university student sample.

Purpose: Food and Alcohol Disturbance (FAD) is characterized by the combination of problematic alcohol use and eating disorder symptoms to offset caloric intake associated with alcohol drinking and/or to enhance intoxication. The Compensatory Eating and Behaviors in Response to Alcohol Consumption Scale (CEBRACS) is a proven tool for measuring FAD, validated in English and Italian populations but never in the French population. The present study aims at validating a French version of the CEBRACS in a representative sample of university students and to determine its validity and reliability.

Postmortem redistribution of cannabinoids: Statistical analysis of a novel dataset and meta-analysis.

The assessment of human postmortem concentrations of Δ-THC (THC) and its metabolites, 11-nor-9-carboxy-THC (THCCOOH) and 11-hydroxy-THC (11-OH-THC), is routinely performed in forensic toxicology laboratories. However, the literature on cannabinoids postmortem redistribution (PMR) is scarce and highlights their complex postmortem changes. This study aims to investigate the postmortem behavior of THC and its metabolites in order to provide practitioners with potential indicators of PMR.

[Promoting physical activity in primary care practices. Review fifteen years after the launch of PAPRICA training].

This article reviews the PAPRICA (Physical Activity promotion in PRImary CAre) program fifteen years after the first training course in physical activity counseling for primary care physicians in French-speaking Switzerland. Subsequent developments are also presented, based on the PAPRICA experience. The article then looks at the national strategy for promoting physical activity in the medical practice, the issues involved in financing the services, and the situation in other comparable countries.

[MedEscapeRoom: an innovative learning method at Unisanté. A course offered as part of pre-graduate medical training].

Teaching methods in the health sciences are evolving with societal changes and the needs of new generations. Gamification in the field of medical education is a fast-growing theme. The use of games in medical training activities engages participants in problem-solving by amplifying their emotional experience and promotes adult learning.

[Borderline psychiatric disorder in the general hospital : specificity and clinical challenges].

Borderline personality disorder (BPD) is a psychiatric condition frequently encountered at the general hospital. This article will focus on the multiple presentation of this mental illness in the aforementioned setting, such as chronic somatic disease, multiple physical complaints as well as chronic pain, all of which that could severely alter the life quality. In this context, especially if there is an unsatisfied need for reinsurance, risk taking behavior (self-harm or harming others) may arise, as well as significant rise of medical costs through multiple medical consultations, longer average lengths of stay and additional complementary examinations.

Influence of macular pigment on the sensitivity to discomfort glare from daylight.

Understanding the factors that influence the human perception of glare is necessary to properly address glare risks in buildings and achieve comfortable visual environments, especially in the workplace. Yet large inter-individual variabilities in glare perception remain unexplained and thus uncovered by the current empirical glare models. We hypothesize that this variability has an origin in the human retina, in particular in the density of macular pigments present in its central area, which varies between individuals.

[Transitional care from hospital to home: how to target the right population?].

When patients are discharged from the hospital and return home, they are at risk of adverse events if the continuity of care is broken. So far, the evidence for transitional care models to reduce readmission rates has focused mainly on patients with a single condition. Based on this observation, we identified the population that may benefit the most from the development of a new transitional care model, as part of the INSTEAD project, by consensus between patients and professionals in hospitals and the community.

Relationship Between Effort-Reward Imbalance, Over-Commitment and Occupational Burnout in the General Population: A Prospective Cohort Study.

To prospectively investigate the association between Effort-Reward Imbalance (ERI) and over-commitment and the scores of the burnout dimensions over a 4 years follow-up period considering potential confounders. Data stemmed from CoLaus|PsyCoLaus, a population-based cohort study including 575 participants (mean age 55 years, 50% men). Participants completed the Maslach Burnout Inventory-General Survey, ERI and over-commitment questionnaires at baseline (T1) and after a 4 years follow-up (T2), and provided demographic, behavioral, psychiatric, personality and social support information through self-reported questionnaires and semi-structured interviews.

[Patients experiencing burnout : medico-social needs and resources].

There is a gap between the current service offer and the needs of people suffering from burnout. Actors in the field, from employers to prescribers, have a role to play in addressing the health needs of the target population, promoting existing services and facilitating their integrative collaboration. This is what a study evaluating the adequacy between the health needs of people experiencing burnout and the services offered to these patients from the point of view of key informants in the canton of Vaud has shown.

[Risk assessment of drugs during breastfeeding].

Medication intake during the postpartum period is common with discontinuation of breastfeeding sometimes unnecessarily recommended for fear of adverse effects in the breastfed infant, while exposure through human milk is generally low. The assessment of risks associated with medication intake during breastfeeding is based, among other things, on the little clinical evidence available in specialized sources of information, and on pharmacokinetic principles. A decision-making support is presented to facilitate communication with mothers, foster medication adherence and prevent unnecessary interruption of breastfeeding.

[Hematological workup in cases of recurrent early miscarriages: what evidences?].

Recurrent miscarriages have a major psychological and somatic impact, as well as a significant economic burden. An etiological work-up should be offered after two or three miscarriages, the threshold varying from one scientific society to another. However, the proposed biological work-up must be justified by scientific evidence.