958 results match your criteria: "Universite de Caen-Basse Normandie[Affiliation]"

The fabrication of low-porosity ceramics for humidity sensing is crucial to prevent moisture entrapment, which poses significant challenges. Using Spark Plasma Sintering (SPS), we successfully densified fine-grained ceramic materials based on LiF-doped MgTiO, comparing them with conventionally sintered counterparts. Structural and microstructural analyses, employing X-ray diffraction and Scanning Electron Microscopy (SEM), were conducted.

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Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV).

J Invest Dermatol

September 2024

Laboratory of Human Molecular Genetics, de Duve Institute, UCLouvain, Brussels, Belgium; Center for Vascular Anomalies, Division of Plastic Surgery, VASCERN VASCA European Reference Center, Cliniques Universitaires Saint Luc, UCLouvain, Brussels, Belgium; WELBIO Department, WEL Research Institute, Wavre, Belgium. Electronic address:

Article Synopsis
  • Common capillary malformations typically involve mutations in GNAQ or GNA11, but this study found other genetic causes by analyzing 82 lesions for mutations in PIK3R1 and PIK3CA.
  • The researchers identified 9 somatic pathogenic variants that led to a specific phenotype, characterized by pale capillary malformations with visible dilated veins and abnormal signaling pathways related to disease development.
  • Using zebrafish embryos, they demonstrated that these mutations affect vascular development, and highlighted that the elevated Akt signaling caused by the mutations can be countered by specific inhibitors, paving the way for potential targeted treatments.
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Intra- and Intermolecular Cation-π Interactions between Onium Salts and Alkynes/Acetylene: Experimental and Theoretical Insights.

J Org Chem

October 2023

Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, COBRA UMR 6014, INC3M FR 3038, F-76000 Rouen, France.

Cation-π interactions between various onium salts, alkynes, and acetylene were studied, taking into account the substituents of the triple bond, the nature of the anions, and the polarity of the solvent, through a combination of MP2 calculations and experiments. In an intramolecular setting, these data (including single-crystal X-ray crystallography) concurred with the stability of folded conformers of alkynyl onium salts, even substituted with electron-withdrawing groups. To examine the contribution of these interactions on the alkyne electronic population, a thorough in silico study was carried out using natural bonding orbital analysis of the conformers.

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Nuisance, allergy, and vector role: mosquitoes are responsible for numerous inconveniences. Several strategies have been employed to fight against this confirmed vector. To record the diversity of mosquito vectors in Camargue (France) and assess the effectiveness of the Qista trap, six BAMs were deployed as a belt barrier to protect the Espeyran Castle (Saint-Gilles, Camargue).

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More and more attention is being paid to the influence of powder mixing on the mechanical properties and corrosion resistance of WC-based cemented carbides. In this study, WC was mixed with Ni and Ni/Co, respectively, by chemical plating and co-precipitated-hydrogen reduction, which are labelled as WC-Ni, WC-Ni/Co, WC-Ni and WC-Ni/Co, respectively. After being densified in a vacuum, the density and grain size of CP were denser and finer than those of EP were.

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The brown mussel Perna perna is a valuable fishing resource, primarily in tropical and subtropical coastal regions. Because of their filter-feeding habits, mussels are directly exposed to bacteria in the water column. Escherichia coli (EC) and Salmonella enterica (SE) inhabit human guts and reach the marine environment through anthropogenic sources, such as sewage.

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[Improving the accuracy of the preoperative planning of mandibular osteogenic distraction by an external custom-made device].

Ann Chir Plast Esthet

April 2023

Service de chirurgie maxillo-faciale, centre hospitalo-universitaire de Caen, France; Faculté de médecine du Caen, université de Caen Basse-Normandie, 14032 Caen cedex 5, France; Normandie university unicaen, Bioconnect, 14000 Caen, France.

Purpose: The aim of this study was to analyze the predictability of virtual surgical planning of mandibular reconstruction by osteogenic distraction (OD) with a custom-made osteogenic distraction device (DEOS) after ballistic trauma and to make recommendations to mitigate potential sources of discrepancy.

Methods: This retrospective study involved 12 patients who were victims of facial mandibular ballistic trauma and were reconstructed with osteogenic distraction with a DEOS device. Postoperative images were compared to the planned situation by means of several measures made in two plans : distraction plane and frontal plane.

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The VASCERN-VASCA working group diagnostic and management pathways for lymphatic malformations.

Eur J Med Genet

December 2022

Center for Vascular Anomalies, Division of Plastic Surgery, University Clinics Saint-Luc, University of Louvain, Brussels, Belgium; VASCERN VASCA European Reference Centre University of Louvain, Brussels, Belgium; Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium.

Lymphatic malformations (LMs) are developmental defects of lymphatic vessels. LMs are histologically benign lesions, however, due to localization, size, and unexpected swelling, they may cause serious complications that threaten vital functions such as compression of the airways. A large swelling of the face or neck may also be disfiguring and thus constitute a psychological strain for patients and their families.

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Pooled resequencing of larvae and adults reveals genomic variations associated with Ostreid herpesvirus 1 resistance in the Pacific oyster .

Front Immunol

September 2022

Chinese Academy of Sciences (CAS) and Shandong Province Key Laboratory of Experimental Marine Biology and Center of Deep Sea Research, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.

The Ostreid herpesvirus 1 (OsHV-1) is a lethal pathogen of the Pacific oyster (), an important aquaculture species. To understand the genetic architecture of the defense against the pathogen, we studied genomic variations associated with herpesvirus-caused mortalities by pooled whole-genome resequencing of before and after-mortality larval samples as well as dead and surviving adults from a viral challenge. Analysis of the resequencing data identified 5,271 SNPs and 1,883 genomic regions covering 3,111 genes in larvae, and 18,692 SNPs and 28,314 regions covering 4,863 genes in adults that were significantly associated with herpesvirus-caused mortalities.

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Case report study of thalidomide therapy in 18 patients with severe arteriovenous malformations.

Nat Cardiovasc Res

June 2022

Division of Plastic Surgery, Center for Vascular Anomalies, Cliniques universitaires Saint-Luc, UCLouvain, VASCERN VASCA European Reference Centre, Brussels, Belgium.

Arteriovenous malformations (AVMs) are fast-flow lesions that may be destructive and are the most difficult-to-treat vascular anomalies. Embolization followed by surgical resection is commonly used; however, complete resection is rarely possible and partial resection often leads to dramatic worsening. Accumulating data implicate abnormal angiogenic activity in the development of AVMs.

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In this paper, we propose a new privatization mechanism based on a naive theory of a perturbation on a probability using wavelets, such as a noise perturbs the signal of a digital image sensor. Wavelets are employed to extract information from a wide range of types of data, including audio signals and images often related to sensors, as unstructured data. Specifically, the cumulative wavelet integral function is defined to build the perturbation on a probability with the help of this function.

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Background: Art therapy (AT) as supportive care may help patients cope with cancer treatments. This non-blinded randomized trial assessed the impact of creative AT on severe fatigue and quality of life (QoL) in localized breast cancer patients undergoing irradiation.

Material And Methods: 320 patients were randomized to an AT group (ATG; 8 weekly sessions starting during irradiation) or to a standard group (SG).

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The VASCERN-VASCA working group diagnostic and management pathways for severe and/or rare infantile hemangiomas.

Eur J Med Genet

June 2022

Center for Vascular Anomalies, Division of Plastic Surgery, University Clinics Saint-Luc, University of Louvain, VASCERN VASCA European Reference Centre, Brussels, Belgium; Human Molecular Genetics, de Duve Institute, University of Louvain, Brussels, Belgium.

The European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN), is dedicated to gathering the best expertise in Europe and provide accessible cross-border healthcare to patients with rare vascular diseases. Infantile Hemangiomas (IH) are benign vascular tumors of infancy that rapidly growth in the first weeks of life, followed by stabilization and spontaneous regression. In rare cases the extent, the localization or the number of lesions may cause severe complications that need specific and careful management.

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Chronic inflammation associated with intestinal architecture and barrier disruption puts patients with inflammatory bowel disease (IBD) at increased risk of developing colorectal cancer (CRC). Widely used to reduce flares of intestinal inflammation, 5-aminosalicylic acid derivatives (5-ASAs) such as mesalazine appear to also exert more direct mucosal healing and chemopreventive activities against CRC. The mechanisms underlying these activities are poorly understood and may involve the up-regulation of the cadherin-related gene MUCDHL (CDHR5).

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Article Synopsis
  • Germ cell tumors and sex cord stromal tumors are rare ovarian cancers primarily affecting young women, generally treated with conservative surgery and chemotherapy (BEP), which may lead to long-term health issues.
  • The GINECO-VIVROVAIRE study aims to evaluate chronic fatigue, quality of life, and long-term side effects of chemotherapy, especially concerning cardiovascular and pulmonary health in survivors.
  • The study involves comparing 134 ovarian cancer survivors treated with surgery and chemotherapy to control groups, and further medical evaluations will be conducted on a subgroup to assess long-term effects and associated costs.
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Trans-disciplinary diagnosis for an in-depth reform of regulatory expertise in the field of environmental toxicology and security.

Toxicol Res

October 2021

Committee for Independent Research and Information on Genetic Engineering (CRIIGEN), 42 rue de Lisbonne, 75008 Paris, France.

Repeated health and environmental scandals, the loss of biodiversity and the recent burst of chronic diseases constantly remind us the inability of public authorities and risk assessment agencies to protect health and the environment. After reviewing the main shortcomings of our evaluation system of chemicals and new technologies, supported by some concrete examples, we develop a number of proposals to reform both the risk assessment agencies and the evaluation processes. We especially propose the establishment of an independent structure, a High Authority of Expertise, supervising, either at European level or at national level, all the evaluation agencies, and ensuring the transparency, the methodology and the deontology of the expertise.

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Adult brainstem glioma presenting with isolated persistent hemifacial spasm or facial nerve palsy.

Rev Neurol (Paris)

December 2021

Université de Caen Basse-Normandie, UFR de Médecine, 14000 Caen, France; Service de neurologie, CHU de Caen, 14000 Caen, France; Service de neurologie, CHU de Nîmes, 30029 Nîmes, France. Electronic address:

Object: Adult brainstem gliomas are a rare group of heterogeneous brain tumors. Classical clinical presentation includes progressive impairment of cranial nerves associated with long tract signs. The prognosis and response to treatment are poor; nevertheless, some patients do have a long survival.

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Monte Carlo transport of swift protons and light ions in water: The influence of excitation cross sections, relativistic effects, and Auger electron emission in w-values.

Phys Med

August 2021

Grupo de Física Biomédica, Instituto de Física de Rosario (CONICET-UNR) and Facultad de Ciencias Exactas, Ingeniería y Agrimensura, Universidad Nacional de Rosario (UNR), C.P.2000 Rosario, Argentina.

Purpose: To develop a particle transport code to compute w-values and stopping power of swift ions in liquid water and gases of interest for reference dosimetry in hadrontherapy. To analyze the relevance of inelastic and post-collisional processes considered.

Methods: The Monte Carlo code MDM was extended to the case of swift ion impact on liquid water (MDM-Ion).

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In this paper, we introduce a new family of distributions whose probability density function is defined as a weighted sum of two probability density functions; one is defined as a warped version of the other. We focus our attention on a special case based on the exponential distribution with three parameters, a dilation transformation and a weight with polynomial decay, leading to a new life-time distribution. The explicit expressions of the moments generating function, moments and quantile function of the proposed distribution are provided.

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Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations.

Orphanet J Rare Dis

June 2021

Human Molecular Genetics, de Duve Institute, University of Louvain, Avenue Hippocrate 74 (+5), bte B1.74.06, 1200, Brussels, Belgium.

Background: Theragnostic management, treatment according to precise pathological molecular targets, requests to unravel patients' genotypes. We used targeted next-generation sequencing (NGS) or digital droplet polymerase chain reaction (ddPCR) to screen for somatic PIK3CA mutations on DNA extracted from resected lesional tissue or lymphatic endothelial cells (LECs) isolated from lesions. Our cohort (n = 143) was composed of unrelated patients suffering from a common lymphatic malformation (LM), a combined lymphatic malformation [lymphatico-venous malformation (LVM), capillaro-lymphatic malformation (CLM), capillaro-lymphatico-venous malformation (CLVM)], or a syndrome [CLVM with hypertrophy (Klippel-Trenaunay-Weber syndrome, KTS), congenital lipomatous overgrowth-vascular malformations-epidermal nevi -syndrome (CLOVES), unclassified PIK3CA-related overgrowth syndrome (PROS) or unclassified vascular (lymphatic) anomaly syndrome (UVA)].

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Biostimulant impacts of Glutacetine® and derived formulations (VNT1 and VNT4) on the bread wheat grain proteome.

J Proteomics

July 2021

Normandie Univ, UNICAEN, INRAE, UMR EVA, SFR Normandie Végétal FED4277, Esplanade de la Paix, F-14032 Caen, France.

Nitrogen (N) fertilizer is essential to ensure grain yield and quality in bread wheat. Improving N use efficiency is therefore crucial for wheat grain protein quality. In the present work, we analysed the effects on the winter wheat grain proteome of biostimulants containing Glutacetine® or two derived formulations (VNT1 and 4) when mixed with urea-ammonium-nitrate fertilizer.

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Marine diazotrophs are a diverse group with key roles in biogeochemical fluxes linked to primary productivity. The unicellular, diazotrophic cyanobacterium is widely found in coastal, subtropical oceans. We analyze the consequences of diazotrophy on growth efficiency, compared to NO -supported growth in , to understand how cells cope with N-fixation when they also have to face carbon limitation, which may transiently affect populations in coastal environments or during blooms of phytoplankton communities.

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Reply to the Letter from Grégoire Micicoi et al.

Orthop Traumatol Surg Res

April 2021

Ramsay Générale de Santé, Hôpital Privé Jean-Mermoz, Centre Orthopédique Santy, 24, avenue Paul-Santy, 69008 Lyon, France.

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Phylogeny and Biogeography of Spinicaudata (Crustacea: Branchiopoda).

Zool Stud

August 2020

Kansas Biological Survey, and The Biodiversity Institute, The University of Kansas, Higuchi Hall, 2101 Constant Avenue, Lawrence, KS 66047-3759, USA. E-mail: (Rogers).

Article Synopsis
  • Spinicaudata, a group of spiny clam shrimp, has been around since the Devonian and is now found worldwide in temporary waters; recent phylogenetic analysis reveals complex family structures within this taxon.
  • The study shows Cyzicidae is paraphyletic and proposes a new family, Eocyzicidae, while indicating that some existing genera within Cyzicidae and Leptestheriidae are not monophyletic.
  • Findings suggest that the global distribution of these species is largely due to historical landmass break-up, with evidence of underexplored diversity, including many possibly cryptic species in the spinicaudatan lineage.
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