2,009 results match your criteria: "Universite de Bretagne Occidentale[Affiliation]"

Article Synopsis
  • Inactivation of the A20 gene is linked to a specific form of lymphoma and is studied in patients with haploinsufficiency of A20 (HA20), revealing immune system impacts.
  • In a study of 34 HA20 patients, researchers found that the loss of one A20 gene copy leads to an increase in self-reactive lymphocyte receptors, often seen in lymphomas.
  • The immune changes are driven by a feedback loop involving tumor necrosis factor (TNF), A20, and NF-κB, and can potentially be reversed by anti-TNF treatment, but may still lead to lymphoma development.
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Impact of inhaled sedation on delirium incidence and neurological outcome after cardiac arrest - A propensity-matched control study (Isocare).

Resuscitation

October 2024

Médecine Intensive Réanimation, CHU de la Cavale Blanche, Bvd Tanguy-Prigent, 29609 Brest Cedex, France; Laboratoire de Traitement de l'Information Médicale INSERM Mixte de Recherche Unité 1101, Université de Bretagne Occidentale, France.

Rationale: Poor neurological outcome is common following a cardiac arrest. The use of volatile anesthetic agents has been proposed during post-resuscitation to improve outcome.

Objectives: To determine the effects of inhaled isoflurane on neurological outcome, delirium incidence, ICU length-of-stay, ventilation duration, mortality during post-resuscitation care of ICU patients.

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Article Synopsis
  • This study evaluates the effectiveness of non-contrast-enhanced 4D MR angiography (NCE-4D-MRA) versus contrast-enhanced 4D MR angiography (CE-4D-MRA) for diagnosing brain arteriovenous malformations (bAVMs), using digital subtraction angiography (DSA) as a reference.
  • Researchers analyzed MRA results from 43 patients and found that NCE-4D-MRA had higher accuracy (0.85) and specificity (95%) than CE-4D-MRA (0.83 accuracy and 85% specificity).
  • The study suggests that NCE-4D-MRA might be a safer diagnostic option for bAVMs, providing
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Article Synopsis
  • The study investigates the demographic history of France using genotype datasets from individuals in Northern France, revealing significant population structure and differentiation in regions like Brittany and the Loire basin.
  • The research highlights a connection between the ancestry of local populations and genetic variations, particularly indicating a distinction in shared ancestry related to Neolithic and steppe populations.
  • Findings suggest the necessity of studying local demographics to better comprehend the distribution of genetic variants and their role in the prevalence of diseases among populations in Brittany and neighboring areas.
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Background And Objectives: To develop and test VMseg, a new image processing algorithm performing automatic segmentation of retinal non-perfusion in widefield OCT-Angiography images, in order to estimate the non-perfusion index in diabetic patients.

Methods: We included diabetic patients with severe non-proliferative or proliferative diabetic retinopathy. We acquired images using the PlexElite 9000 OCT-A device with a photomontage of 5 images of size 12 x 12 mm.

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[Anatomical cartography of the radial nerve at the elbow level for intraradial nerve transfers for finger extension reconstruction in spastic upper limb - A cadaveric study].

Ann Chir Plast Esthet

September 2024

Service de chirurgie de la main et des brûlés, CHU de Grenoble Alpes, hôpital Michallon, Grenoble, France. Electronic address:

Introduction: Upper limb spasticity is a surgical challenge, both in diminishing agonists spasticity and reconstructing antagonist function. Brachioradialis (BR) is often involved in elbow flexors spasticity. Finger extension is often impaired in spastic patients.

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Chemsex defines the practice of sexual activity under the influence of psychoactive substances, mainly by Men who have Sex with Men (MSM). This activity can be associated with negative health consequences, yet there are no recommendations to guide management of individuals who engage in chemsex. The aim of this scoping review was to identify and describe the existing treatments (pharmacological or not) and risk/harm reduction strategies for MSM who engage in chemsex.

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Triiron Complexes Featuring Azadiphosphine Related to the Active Site of [FeFe]-Hydrogenases: Their Redox Behavior and Protonation.

Molecules

July 2024

Laboratoire de Chimie, Electrochimie Moléculaire et Chimie Analytique, UMR 6521 CNRS-Université de Bretagne Occidentale, CS 93837-6 Avenue Le Gorgeu, CEDEX 3, 29238 Brest, France.

Article Synopsis
  • - The study focuses on designing iron clusters with a bimetallic core and multiple protonation sites to better understand polymetallic active sites like the H-cluster in [FeFe]-hydrogenases.
  • - Complexes were synthesized via reactions of hexacarbonyl precursors and mononuclear complexes to incorporate amine functions near the triiron core, aiming to investigate their reactivity and redox properties.
  • - The research identified protonation sites and their interactions, noting that the orientation of protonation processes is influenced by the arrangement of the second coordination sphere, while comparing these triiron species to their dinuclear counterparts.
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Background: In the perioperative setting, the most accurate way to continuously measure arterial blood pressure (ABP) is using an arterial catheter. Surrogate methods such as finger cuff have been developed to allow non-invasive measurements and are increasingly used, but need further evaluation. The aim of this study is to evaluate the accuracy and clinical concordance between two devices for the measurement of ABP during neuroradiological procedure.

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With the growth in maritime traffic comes an increased need for precise modelling, analysis, and visualisation to enhance the monitoring capabilities of maritime authorities. To address this need, a range of sensing technologies have been developed to track vessel movements worldwide. Among these, the Automatic Identification System (AIS) is particularly significant, offering high-frequency transmission of both location and identification data.

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Background And Aims: Home treatment is considered safe in acute pulmonary embolism (PE) patients selected by a validated triage tool (e.g. simplified PE severity index score or Hestia rule), but there is uncertainty regarding the applicability in underrepresented subgroups.

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The effect of adding organized supramolecular systems such as β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the photochemically-induced fluorescence (PIF) spectral properties of -fluvalinate (TFV) in aqueous solutions was examined. The influence of pH, UV irradiation time and photoproduct stability on the cyclodextrin-enhanced photochemically-induced fluorescence intensity was also investigated. The spectral changes associated with the inclusion process yielded values for the formation constants of TFV inclusion complexes between 450 and 640 M, which were calculated using the nonlinear iterative regression approach least squares.

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Soil microbial communities are fundamental to ecosystem processes and plant growth, yet community composition is seasonally and successionally dynamic, which interferes with long-term iterative experimentation of plant-microbe interactions. We explore how soil sample handling (e.g.

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Isotretinoin: Past, present and future. A French perspective.

Ann Dermatol Venereol

September 2024

Centre de Preuves de la Société Française de Dermatologie, 10 Cité Malesherbes, 75009 Paris, France; Groupe DEFI de la Société Française de Dermatologie, 10 Cité Malesherbes, 75009 Paris, France; Consultation dermatoses faciales, AP-HP, Hôpital Universitaire Pitié-Salpêtrière, 75013 Paris, France.

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Horse riding is a popular yet dangerous sport, often resulting in facial traumas due to unpredictable horse reactions or falls. This retrospective study examines 20 patients. The aim of the study is to analyze maxillofacial traumas of equine origin and discuss prevention strategies.

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In the realm of ophthalmology, precise measurement of tear film break-up time (TBUT) plays a crucial role in diagnosing dry eye disease (DED). This study aims to introduce an automated approach utilizing artificial intelligence (AI) to mitigate subjectivity and enhance the reliability of TBUT measurement. We employed a dataset of 47 slit lamp videos for development, while a test dataset of 20 slit lamp videos was used for evaluating the proposed approach.

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Impacts of bycatch from beach seining: a case study of a shrimp fishery in Brazil.

An Acad Bras Cienc

May 2024

Universidade Federal Rural de Pernambuco, Departamento de Ecologia, Rua Dom Manuel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil.

It is commonly assumed that beach seining (BS) is more sustainable than bottom trawling because it involves non-motorized operations and limited fishing power. However, no scientific evidence supports this assumption. To address this gap, we evaluated the impact of beach seining, taking a small-scale shrimp fishery in northeast Brazil.

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Biological invasions pose a rapidly expanding threat to the persistence, functioning and service provisioning of ecosystems globally, and to socio-economic interests. The stages of successful invasions are driven by the same mechanism that underlies adaptive changes across species in general-via natural selection on intraspecific variation in traits that influence survival and reproductive performance (i.e.

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Article Synopsis
  • The volatile fraction of sea fennel was previously well-studied, but its polar constituents and their bioactivities needed further exploration.
  • A hydromethanolic extract of sea fennel leaves was tested for various health benefits, including antioxidant, anti-inflammatory, antidiabetic, neuroprotective, and skin-protective activities, with the polar fractions showing significant effectiveness.
  • Key compounds like chlorogenic acid and quercetin derivatives were identified, suggesting that sea fennel could be a promising source for developing medicinal or nutritional products aimed at combating diabetes, inflammation, and oxidative stress.
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Copper ion is a versatile and ubiquitous facilitator of redox chemical and biochemical processes. These include the binding of molecular oxygen to copper(I) complexes where it undergoes stepwise reduction-protonation. A detailed understanding of thermodynamic relationships between such reduced/protonated states is key to elucidate the fundamentals of the chemical/biochemical processes involved.

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Purpose: The accuracy of target delineation in radiation treatment planning of high-grade gliomas (HGGs) is crucial to achieve high tumor control, while minimizing treatment-related toxicity. Magnetic resonance imaging (MRI) represents the standard imaging modality for delineation of gliomas with inherent limitations in accurately determining the microscopic extent of tumors. The purpose of this study was to assess the survival impact of multi-observer delineation variability of multiparametric MRI (mpMRI) and [F]-FET PET/CT.

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Introduction : Early-onset pneumonia (EOP) occurs in around 50% of critically ill patients with out-of-hospital cardiac arrest (OHCA) and is associated with increased morbidity. Prompt diagnosis of EOP in these patients is difficult because of targeted temperature management and the postcardiac arrest syndrome. We hypothesized that an algorithm for proactive screening of EOP would improve patient outcomes.

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Nirmatrelvir/ritonavir is a promising option for preventing severe COVID-19 in solid organ transplant recipients with SARS-CoV-2 infection. However, concerns have arisen regarding potential drug interactions with calcineurin inhibitors (CNI). This two-phase multicentre retrospective study, involving 113 patients on tacrolimus and 13 on cyclosporine A, aimed to assess the feasibility and outcomes of recommendations issued by The French societies of transplantation (SFT) and pharmacology (SFPT) for CNI management in this context.

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