11,227 results match your criteria: "Universite de Bordeaux[Affiliation]"
Chemistry
December 2024
University of Pardubice: Univerzita Pardubice, Institute of Organic Chemistry and Technology, CZECHIA.
Differently substituted pyrrole-azo‑benzene molecular photoswitches were prepared in a straightforward synthetic way. Their fundamental properties were investigated by XRD analysis, differential scanning calorimetry, thermogravimetric analysis, cyclic voltammetry, UV‑Vis absorption spectroscopy, Hyper-Rayleigh Scattering, and NMR spectroscopy; the experimental results were further corroborated by DFT calculations. Thermal robustness, the HOMO/LUMO levels, and the absorption properties were altered mostly by substituting the N‑methylpyrrole moiety and further fine-tuned by modifying the benzene substituents.
View Article and Find Full Text PDFEur J Neurol
January 2025
Service de Génétique Médicale, CHU Bordeaux, Bordeaux, France.
Purpose: Heterozygous pathogenic variants in SPAST are known to cause Hereditary Spastic Paraplegia 4 (SPG4), the most common form of HSP, characterized by progressive bilateral lower limbs spasticity with frequent sphincter disorders. However, there are very few descriptions in the literature of patients carrying biallelic variants in SPAST.
Methods: Targeted Sanger sequencing, panel sequencing and exome sequencing were used to identify the genetic causes in 9 patients from 6 unrelated families with symptoms of HSP or infantile neurodegenerative disorder.
Sci Rep
December 2024
GIN, IMN-UMR5293, CEA, CNRS, Université de Bordeaux, Bordeaux, France.
Cerebral microbleeds (CMB) represent a feature of cerebral small vessel disease (cSVD), a prominent vascular contributor to age-related cognitive decline, dementia, and stroke. They are visible as spherical hypointense signals on T2*- or susceptibility-weighted magnetic resonance imaging (MRI) sequences. An increasing number of automated CMB detection methods being proposed are based on supervised deep learning (DL).
View Article and Find Full Text PDFAnimal
December 2024
Physiologie de la Reproduction et des Comportements, CNRS, INRAE, Université de Tours, 37380 Nouzilly, France.
Intravaginal sponges impregnated with the progesterone (P4) analogue fluorogestone acetate (FGA) induce synchronous oestrous behaviour and normal ovulatory cycle in goats. To explore alternatives using natural P4 from plants, we developed a method of ethanolic extraction and a specific enzyme immunoassay (EIA) to measure P4 in the different parts of the walnut tree Juglans regia. We found a very high concentration of P4, specifically in the leaves of the three most common French varieties (∼100 mg/kg of DM) but not in flowers, fruits, septa, husk, oil or cake.
View Article and Find Full Text PDFJ Pers Med
December 2024
Centre Hospitalier Universitaire de Bordeaux, Service de Radiologie et Imagerie Médicale de l'adulte, Place Amélie Raba Léon, 33076 Bordeaux, France.
MRI-guided focal laser ablation (MRI-FLA) is an emerging minimally invasive technique for treating localized prostate tumors, aiming to provide effective cancer control while minimizing side effects. This meta-analysis systematically evaluates the clinical outcomes, technical efficacy, and complication rates associated with MRI-FLA to better understand its therapeutic potential and safety profile in prostate cancer management. In July 2024, PubMed (MEDLINE) was searched for eligible trials using the PRISMA guidelines.
View Article and Find Full Text PDFClin Genet
December 2024
IBMC-Institute for Molecular and Cell Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Hereditary spastic paraplegias (HSP) are a diverse group of neurodegenerative diseases characterized by lower limb spasticity and weakness. To date, over 80 genes have been associated with HSP, but many families remain without a molecular diagnosis. In this study, linkage analysis and whole-exome sequencing (WES) were performed to identify the causal gene in a HSP family with autosomal recessive inheritance.
View Article and Find Full Text PDFJ Physiol
December 2024
University of Bordeaux, INSERM, CRCTB, U1045, Pessac, France.
The pericardium plays an important role in mechanical interactions between the right (RV) and left (LV) ventricles, referred to as ventricular interdependence. However, the exact mechanisms of its supportive role remain unknown. The present study aimed to evaluate specifically ventricular interdependence in a model of isolated biventricular working heart of large mammal, which is in absence of neurohormonal influence or series interactions, and to evaluate the impacts of intact pericardium on this phenomenon.
View Article and Find Full Text PDFEClinicalMedicine
January 2025
Department of Dermatology, Saint-Louis Hospital, AP-HP, Paris, France.
[This corrects the article DOI: 10.1016/j.eclinm.
View Article and Find Full Text PDFJoint Bone Spine
December 2024
Université Paris Cité, INSERM U1266, Institut de Psychiatrie et Neuroscience de Paris, Paris, France; Service de Psychiatrie et Addictologie, AP-HP, Hôpital Corentin-Celton, DMU Psychiatrie et Addictologie, Issy-les-Moulineaux, France.
Chemistry
December 2024
Centre National de la Recherche Scientifique, Institut des Sciences Moléculaires, 351 Cours de la libération - Bâtiment A12, 33405, TALENCE CEDEX, FRANCE.
Various protecting groups have been developed for boronic acids, mostly based on diols. Alternatives include trifluoroborates and amine complexes, which offer easier synthesis and release under milder conditions. We present here a new strategy involving photocleavable protecting groups for boronic and borinic acids, based on the 2-nitrobenzyl motif.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Université de Bordeaux, CBMN UMR5248, IECB, 2, rue Robert Escarpit, 33607, PESSAC, FRANCE.
Peptide stapling has emerged as a versatile approach in drug discovery to reinforce secondary structure elements especially α-helices and improve properties of linear bioactive peptides. Inspired by the prevalence of arginine in protein-protein and protein-DNA interfaces, we investigated guanidinium-stapling as a means to constrain helical peptides. Guanidinium stapling was readily achieved on solid support, utilizing two orthogonally protected lysine or unatural α-amino acid residues with an amino function.
View Article and Find Full Text PDFSmall
December 2024
UMR CNRS 5629, laboratoire LCPO, Université de Bordeaux, Pessac, F-33600, France.
This work addresses the structural quantification of multiphase materials, here nanostructured polymer solid precursors and their micro/nano sized foamed counterparts. It is based on a strategy of contrast/edge enhancement, locally adaptive to image data in digital images of materials. The method allows to binarize straightforwardly the structures (the phases) in TEM and SEM images after edge identification, edge choice, and image virtual reconstruction.
View Article and Find Full Text PDFEur Urol Oncol
December 2024
Department of Urology, CHU de Bordeaux, Université de Bordeaux, Bordeaux, France.
Therapie
December 2024
Équipe AHeaD, CHU de Bordeaux, service de pharmacologie clinique, BPH, université de Bordeaux, Inserm U1219, 33000 Bordeaux, France.
The drug authorization process is shifting towards a policy aimed at shortening time-to-market. While this policy facilitates early access to new treatments, it can also result in potentially insufficient knowledge of both efficacy and safety at the time of marketing. The latter is particularly true for long-term outcomes or in specific populations (e.
View Article and Find Full Text PDFArch Cardiovasc Dis
December 2024
Inserm ICAN 1166, Hôpitaux de l'est parisien (Saint-Antoine-Tenon), AP-HP, Sorbonne Université, 184, Faubourg-Saint-Antoine, 75571 Paris cedex, France.
Med Sci (Paris)
December 2024
Centre de recherche Bordeaux Population Health, Inserm U1219, institut de santé publique, d'épidémiologie et de développement, université de Bordeaux, Bordeaux, France.
Biol Methods Protoc
December 2024
Department of Life and Health Sciences, Université de Bordeaux, INSERM U1211, Maladies Rares: Génétique et Métabolisme (MRGM), F-33615, Pessac, France.
The main objective of the ZebraCool programme was to create a positive attitude and curiosity towards science by bringing experimental activities within schools using an introductory cognitive and sensory approach. This innovative programme was offered at all levels of primary and secondary education including vocational high schools. Thematic workshops can be carried out on various themes such as comparative anatomy and embryology, molecular biology and evolution, or toxicology and endocrine disruptors.
View Article and Find Full Text PDFBMJ Open Respir Res
December 2024
Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, Université de Bordeaux, Bordeaux, France.
Introduction: Biologics provide significant benefits in asthma, reducing exacerbations and symptoms. Some biologics have shown promising results in small subgroups of patients with chronic obstructive pulmonary disease (COPD) and frequent exacerbations. Nevertheless, real-life data on the size of the COPD target population remain scarce.
View Article and Find Full Text PDFDiscov Nano
December 2024
Division of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Delhi, 110054, India.
Several approaches have been utilised to deliver therapeutic nanoparticles inside the brain but rendered by certain limitation such as active efflux, non-stability, toxicity of the nanocarrier, transport, physicochemical properties and many more. In this context use of biocompatible nano carriers is currently investigated. We herein present the hypothesis that the nucleoside-lipid based conjugates (nucleolipids) which are biocompatible in nature and have molecular recognition can be tuned for improved permeation across blood-brain barrier (BBB).
View Article and Find Full Text PDFNat Commun
December 2024
Beijing Institute of Tropical Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
The phylum Apicomplexa comprises eukaryotic parasites that cause fatal diseases affecting millions of people and animals worldwide. Their mitochondrial genomes have been significantly reduced, leaving only three protein-coding genes and highly fragmented mitoribosomal rRNAs, raising challenging questions about mitoribosome composition, assembly and structure. Our study reveals how Toxoplasma gondii assembles over 40 mt-rRNA fragments using exclusively nuclear-encoded mitoribosomal proteins and three lineage-specific families of RNA-binding proteins.
View Article and Find Full Text PDFBull Cancer
December 2024
UE7453 CHELTER, Inserm CIC-501, site Estaing, service de thérapie cellulaire et d'hématologie clinique adulte, service d'oncologie médicale, CHU de Clermont-Ferrand, Clermont-Ferrand, France.
The editorial board of the Bulletin du Cancer has compiled a summary of the news from 2024 in oncology, based on the main results presented at international congresses or published over the past year. After a year marked by the success of the Olympic Games, the selection of data is presented and discussed in podiums of three main results by topic. Emphasis is placed on studies that have an immediate impact on practice and on data that raise important questions for the year 2025.
View Article and Find Full Text PDFFront Psychol
December 2024
COMPTRASEC (UMR CNRS 5114), CIECST, GPR HOPE Idex, Université de Bordeaux, Bordeaux, France.
Int J Mol Sci
November 2024
Neurocentre Magendie INSERM U1215, Université de Bordeaux, 33000 Bordeaux, France.
In amyotrophic lateral sclerosis (ALS), early mitochondrial dysfunction may contribute to progressive motor neuron loss. Remarkably, the ectopic expression of the Orthobornavirus bornaense type 1 (BoDV-1) X protein in mitochondria blocks apoptosis and protects neurons from degeneration. Therefore, this study examines the neuroprotective effects of X protein in an ALS mouse model.
View Article and Find Full Text PDFJ Infect
December 2024
Département des Maladies Infectieuses et Tropicales, Hospices Civils de Lyon, F-69004 Lyon, France; Centre International de Recherche en Infectiologie (CIRI), Inserm 1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, F-69007, France.
Introduction: The increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria.
Methods: This retrospective multicentre study investigated the real-world use of FDC in 114 immunocompromised adults treated for MDR infections in 12 French hospitals (June 2020-November 2023).