Neural correlates of unconventional verb extensions reveal preschoolers' analogical abilities.

In the current event-related potential (ERP) study, we assessed 4-year-olds' ability to extend verbs to new action events on the basis of abstract similarities. Participants were presented with images of actions (e.g.

Empirical Analysis of Health Assessment Objective and Subjective Methods on the Determinants of Health.

Background: There are several methods for assessing health status. The aims of this study were to investigate the empirical differences between health assessment objective and subjective methods, to identify a possible long-term relationship between methods and health determinants and the influence of these methods on the perceived level of risk according to health determinants.

Methods: Using data from 1970 to 2018 in the United States, health status was assessed by perception of health, absence from work due to self-reported illness, life expectancy at birth and mortality rate.

Defining Your "Life Territory": The Meaning of Place and Home for Community Dwellers and Nursing Home Residents-A Qualitative Study in Four European Countries.

The meaning of place and home for community dwellers and nursing home residents remains unclear. We explored the relationship between older people and their "life territory", to propose a working definition of this concept, which could be used to orient policy decisions. Individual, semi-structured interviews were performed with older people, nursing home staff, and representatives of local institutions/elected officials in four European countries (France, Belgium, Germany, Italy).

[The orphan child and his family confronted with the violence of deathThe orphan child and his family facing the violent consequences of death].

The death of a parent is a form of extreme violence which has an effect on the child and on the adults around him/her, often leaving them powerless. There are risks of avoidance, of silence about the event and the figure of the deceased, to which can be added a lack of identification of the child's difficulties and the absence of responses adapted to his or her needs, at each stage of development. A better knowledge of their needs could reduce the risk of being negligent, or even ill-treating them, and allow them to grow up, better assured in their filiation and their personal identity.

Serum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab.

Objectives: The study aimed to assess the potential for serum neurofilament light chain (NFL) levels to predict the risk of progressive multifocal leukoencephalopathy (PML) in natalizumab (NTZ)-treated patients with multiple sclerosis (MS) and to discriminate PML from MS relapses.

Methods: NFL levels were measured with single molecule array (Simoa) in 4 cohorts: (1) a prospective cohort of patients with MS who developed PML under NTZ therapy (pre-PML) and non-PML NTZ-treated patients (NTZ-ctr); (2) a cohort of patients whose blood was collected during PML; (3) an independent cohort of non-PML NTZ-treated patients with serum NFL determinations at 2 years (replication cohort); and (4) a cohort of patients whose blood was collected during exacerbations.

Results: Serum NFL levels were significantly increased after 2 years of NTZ treatment in pre-PML patients compared with NTZ-ctr.

Being useful among persons aged over 65: social representations from a cross-sectional European study.

Background: There is a compelling need to prepare our societies and healthcare systems to deal with the oncoming wave of population ageing. The majority of older persons maintain a desire to be valued and useful members of society and of their social networks.

Aims: We sought to investigate the perception of usefulness among persons aged 65 years and over in four European countries.

[Towards a personalized support necessary but complex to implement. The exemple of oncogeriatric care].

The considerable developments in the field of oncology have led to increased life expectancy and are contributing to conceptual changes in the care and management of patients. As such, the introduction of supportive care represents the archetype of a new "person-centred" approach and its characteristic needs. While the chronicity of the disease reflects advances in treatment, it also raises questions about a particularly long, cumbersome and painful treatment process for an aging and vulnerable population.

[Complementary and alternative medicine: what place in geriatric medicine?].

This article is about the development of complementary and alternative medicine in geriatrics. He questions the meaning of his practices - and more broadly that of relational and non-drug care - as well as their application in the field in the aging sector. Indeed, the promotion of non-drug therapies by the high health authority, the growing role of actors in relational care or the emergence of practices complementary attest to a new dynamic of care in favor of a more global approach to support.

[Towards a personalized support necessary but complex to implement. The exemple of oncogeriatric care].

The considerable developments in the field of oncology have led to increased life expectancy and are contributing to conceptual changes in the care and management of patients. As such, the introduction of supportive care represents the archetype of a new "person-centred" approach and its characteristic needs. While the chronicity of the disease reflects advances in treatment, it also raises questions about a particularly long, cumbersome and painful treatment process for an aging and vulnerable population.

Cooperation in Online Conversations: The Response Times as a Window Into the Cognition of Language Processing.

Measuring the cognitive cost of interpreting the meaning of sentences in a conversation is a complex task, but it is also at the core of Sperber and Wilson's Relevance Theory. In cognitive sciences, the delay between a stimulus and its response is often used as an approximation of the cognitive cost. We have noticed that such a tool had not yet been used to measure the cognitive cost of interpreting the meaning of sentences in a free-flowing and interactive conversation.

Late Functional Changes Post-Severe Traumatic Brain Injury Are Related to Community Reentry Support: Results From the PariS-TBI Cohort.

Objectives: To explore late functional changes after a traumatic brain injury and their relation to patients' characteristics and reentry support.

Design: Prospective follow-up of an inception cohort of adults with severe traumatic brain injury recruited in 2005-2007 in the Parisian area, France. One and 4-year assessments were performed by trained neuropsychologists.

Normalisation of brain spectroscopy findings in Niemann-Pick disease type C patients treated with miglustat.

Niemann-Pick disease type C (NP-C) is a fatal progressive neurolipidosis involving neuronal storage of cholesterol and gangliosides. Miglustat, an inhibitor of glycosphingolipid synthesis, has been approved to treat neurological manifestations in adults and children with NP-C. This open-label observational study in adults with confirmed NP-C evaluated the efficacy of miglustat (200 mg t.

Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome.

Background: Macrophages are important components of inflammatory processes in multiple sclerosis, closely linked to axonal loss, and can now be observed in vivo using ultra-small superparamagnetic iron oxide (USPIO). In the present 1-year longitudinal study, we aimed to determine the prevalence and the impact on tissue injury of macrophage infiltration in patients after the first clinical event of multiple sclerosis.

Methods: Thirty-five patients, 32 years mean age, were imaged in a mean of 66 days after their first event using conventional magnetic resonance imaging, gadolinium (Gd) to probe blood-brain barrier integrity, USPIO to study macrophage infiltration and magnetization transfer ratio (MTR) to assess tissue structure integrity.

Progressive neuropsychiatric manifestations of phenylketonuria in adulthood.

Introduction: Neuropsychiatric signs and MRI abnormalities can occur in patients with phenylketonuria in adulthood. We describe clinical and radiological features of phenylketonuric patients and we discuss the advantage of continuing diet in adulthood.

Method: We report late onset neuropsychiatric symptoms of four phenylketonuric patients (33-45years) diagnosed in infancy and report the case of a patient (33years) diagnosed with phenylketonuria because of late onset neurological signs.

[A guide to advance health care directives].

Since the law of 22nd April 2005, any patient at the end of their life can draw up advance health care directives indicating their wishes with regard to the care and treatments they would like or not like to receive if they are no longer able to communicate. Valid for three years and included in the patient's records, the doctor must consult them but is not obliged to follow them.

[Bipolar shoulder prosthesis for rheumatoid arthritis with irreparable rotator cuff tear: results after 5 years' follow-up].

Purpose Of The Study: The goal of this study was to assess the clinical and radiological outcome of bipolar shoulder prosthesis in twelve shoulders with rheumatoid arthritis (RA) and irreparable rotator cuff tears.

Material And Methods: The follow-up was more than five years (range 2-9 years). In addition, in order to investigate the effect of rheumatoid arthritis on outcome, results were compared with ten bipolar shoulder prostheses implanted for osteoarthritis with massive rotator cuff tears.