Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm.

Childhood maltreatment exposure (CME) increases the risk of adverse long-term health consequences for the exposed individual. Animal studies suggest that CME may also influence the health and behaviour in the next generation offspring through CME-driven epigenetic changes in the germ line. Here we investigated the associated between early life stress on the epigenome of sperm in humans with history of CME.

How Residual Fertility Impacts the Efficiency of Crop Pest Control by the Sterile Insect Technique.

The sterile insect technique (SIT) is a biological control technique based on mass-rearing, radiation-based sterilization that can induce fitness costs, and releases of the pest species targeted for population control. Sterile matings, between females and sterilized males, can reduce the overall population growth rate and cause a fall in population density. However, a proportion of irradiated males may escape sterilization, resulting in what is called residual fertility.

Clinical Manifestations.

Background: Speech and language impairments are associated with cognitive decline in neurodegenerative dementias, particularly Alzheimer's Disease (AD), where subtle speech changes may precede clinical dementia onset. As clinical trials prioritize early identification for disease-modifying treatments, digital biomarkers for timely screening become imperative. Digital speech-based biomarkers can be employed for screening populations at the earliest AD stages.

PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression.

Our study explores the complex dynamics of the integrated stress response (ISR) axis, highlighting PIM2 kinase's critical role and its interaction with the BCL2 protein family, uncovering key mechanisms of cell survival and tumor progression. Elevated PIM2 expression, a marker of various cancers, often correlates with disease aggressiveness. Using a model of normal and malignant plasma cells, we show that inhibiting PIM2 kinase inhibits phosphorylated BAD production and activates ISR-mediated NOXA expression.

[Visions and repercussions of identity-release in oocyte and sperm donors : descriptive survey among gamete donors].

Objectives: The Bioethics Law of August 2nd, 2021 established access to origins for people conceived by gamete donation. Two years after the implementation of this disposition, what is the proportion of former gamete donors informed about access to origins, and what is their position on this matter? What could be the potential repercussions of this new law on them? .

Methods: Retrospective single-center cohort study using questionnaires Results: When former gamete donors were asked about access to origins, only 53 % of oocytes donors and 71 % of sperm donors were aware of this measure.

Haematometabolism rewiring in atherosclerotic cardiovascular disease.

Atherosclerotic cardiovascular diseases are the most frequent cause of death worldwide. The clinical complications of atherosclerosis are closely linked to the haematopoietic and immune systems, which maintain homeostatic functions and vital processes in the body. The nodes linking metabolism and inflammation are receiving increasing attention because they are inextricably linked to inflammatory manifestations of non-communicable diseases, including atherosclerosis.

EGFR status assessment using reflex testing targeted next-generation sequencing for resected non-squamous non-small cell lung cancer.

EGFR status assessment is mandatory for adjuvant decision-making of resected stage IB-IIIA non-squamous non-small cell lung cancer (NS-NSCLC). It is questionable whether single-gene RT-PCR versus next-generation sequencing (NGS) should be used for this evaluation. Moreover, co-occurring mutations have an impact on tumor behavior and may influence future therapeutic decision-making.

Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis.

Meiosis, endoreplication, and asynthetic fissions are variations of the canonical cell cycle where either replication or mitotic divisions are muted. Here, we identify a cell cycle variantconserved across organs and mammals, where both replication and mitosis are muted, and that orchestrates the differentiation of post-mitotic progenitors into multiciliated cells (MCCs). MCC progenitors reactivate most of the cell cycle transcriptional program but replace the temporal expression of cyclins E2 and A2 with non-canonical cyclins O and A1.

Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation.

Multiciliated cells (MCCs) ensure fluid circulation in various organs. Their differentiation is marked by the amplification of cilia-nucleating centrioles, driven by a genuine cell-cycle variant, which is characterized by wave-like expression of canonical and non-canonical cyclins such as Cyclin O (CCNO). Patients with CCNO mutations exhibit a subtype of primary ciliary dyskinesia called reduced generation of motile cilia (RGMC).

Impact of post-traumatic stress disorder on epileptogenic networks: a functional connectivity study.

Post-traumatic stress disorder (PTSD) is more common in patients with drug-resistant epilepsy. Some of these patients experience PTSD due to early psychotraumatic events. This study aims to assess the influence of PTSD on interictal functional connectivity using stereoelectroencephalography (SEEG) recordings in patients with temporal lobe DRE (TDRE).

Comparative analysis of creative problem solving tasks across age groups using modular cube robotics.

Creative Problem Solving (CPS) is an important competency when using digital artifacts for educational purposes. Using a dual-process approach, this study examines the divergent thinking scores (fluidity, flexibility, and originality) and problem-solving speed in CPS of different age groups. Participants engaged in CreaCube CPS tasks with educational robotics for two consecutive instances, with performance analyzed to explore the influence of prior experience and creative intentions.

A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging.

Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated ganglioside GD3 at their surface. The increased level of GD3 expression on senescent cells that naturally occurs upon aging in liver, lung, kidney or bones leads to a strong suppression of NK-cell-mediated immunosurveillance.

Impacts of acid mine drainage remediation in the largest gold mine of Latin America on natural water bodies in the Dominican Republic.

Impacts of the acid mine drainage (AMD) remediation are investigated on the largest gold mine in Latin America, located in the Dominican Republic. Geochemical analysis of suspended matter in water performed in 2022 on water bodies located downstream to the mine, namely, the Margajita River and Lake Hatillo, are compared with analyses made in 2007, before the AMD remediation. The results for the Margajita River show a strong decrease in heavy metal and metalloid concentrations in the dissolved phase for Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Sb, and Pb (between 89.

A Copper-Binding Peptide with Therapeutic Potential against Alzheimer's Disease: From the Blood-Brain Barrier to Metal Competition.

Alzheimer's disease (AD) is the most common form of dementia worldwide. AD brains are characterized by the accumulation of amyloid-β peptides (Aβ) that bind Cu and have been associated with several neurotoxic mechanisms. Although the use of copper chelators to prevent the formation of Cu-Aβ complexes has been proposed as a therapeutic strategy, recent studies show that copper is an important neuromodulator that is essential for a neuroprotective mechanism mediated by Cu binding to the cellular prion protein (PrP).

Processing order in short-term memory is spatially biased in children.

When processing serial information, adults tend to map elements of a sequence onto a mental horizontal line, following the direction of their reading and writing system. For example, in a Western population, the beginning of a series is associated with the left-hand side of the mental line, while its end is preferentially associated with the right. To complete the few studies that have investigated the cultural vs.

When to stop immunotherapy for advanced melanoma: the emulated target trials.

Background: Immune checkpoint inhibitors (ICIs) have demonstrated their efficacy with a 7.5-year overall survival (OS) close to 50% for advanced stages. The design of clinical trials provides for treatment until progression or toxicity, or for a maximum duration of two years.

Systematic characterization of the barrier function of diverse models of damaged human skin.

Background: The skin barrier plays a crucial role in protecting our body against external agents. Disruption of this barrier's function leads to increased susceptibility to infections and dermatological diseases. Damaged skin can be due to the use of detergents, sunburn or excessive scratching.

A new regulation mechanism for KCNN4, the Ca-dependent K channel, by molecular interactions with the Capump PMCA4b.

KCNN4, a Ca-activated K channel, is involved in various physiological and pathological processes. It is essential for epithelial transport, immune system and other physiological mechanisms but its activation is also involved in cancer pathophysiology as well as red blood cell disorders (RBC). The activation of KCNN4 in RBC leads to loss of KCl and water, a mechanism known as the "Gardos effect" described seventy years ago.

In Situ Measurements of Light Diffusion in an Optically Dense Atomic Ensemble.

This study introduces a novel method to investigate in situ light transport within optically thick ensembles of cold atoms, exploiting the internal structure of alkaline-earth metals. A method for creating an optical excitation at the center of a large atomic cloud is demonstrated, and we observe its propagation through multiple scattering events. In conditions where the cloud size is significantly larger than the transport mean free path, a diffusive regime is identified.

Tunable Generation of Spatial Entanglement in Nonlinear Waveguide Arrays.

Harnessing high-dimensional entangled states of light presents a frontier for advancing quantum information technologies, from fundamental tests of quantum mechanics to enhanced computation and communication protocols. In this context, the spatial degree of freedom stands out as particularly suited for on-chip integration. But while traditional demonstrations produce and manipulate path-entangled states sequentially with discrete optical elements, continuously coupled nonlinear waveguide systems offer a promising alternative where photons can be generated and interfere along the entire propagation length, unveiling novel capabilities within a reduced footprint.

Spatial distribution of SARS-CoV-2 incidence, social inequality, housing conditions, and density in South-Eastern France: keys for future epidemics.

Introduction: Early in 2021, the SARS-CoV-2 incidence rate was higher in the East than in the West of the Alpes-Maritimes district in France. What was the impact of social deprivation, household overcrowding and population density per km on this difference in incidence rate?

Methods: Cases were defined as persons with a first SARS-CoV-2 positive test detected between 04/01/2021 and 14/02/2021. We studied the « French Deprivation index » (FDep), rate of overcrowded households and population density/km.

Multiple-timescale dynamics, mixed mode oscillations and mixed affective states in a model of bipolar disorder.

Mixed affective states in bipolar disorder (BD) is a common psychiatric condition that occurs when symptoms of the two opposite poles coexist during an episode of mania or depression. A four-dimensional model by Goldbeter (Progr Biophys Mol Biol 105:119-127, 2011; Pharmacopsychiatry 46:S44-S52, 2013) rests upon the notion that manic and depressive symptoms are produced by two competing and auto-inhibited neural networks. Some of the rich dynamics that this model can produce, include complex rhythms formed by both small-amplitude (subthreshold) and large-amplitude (suprathreshold) oscillations and could correspond to mixed bipolar states.