Partner treatment strategies for Chlamydia and Gonorrhea: Time for a reappraisal.

Objectives: Epidemiological treatment for suspected Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections is recommended for exposed partners before laboratory confirmation, within 14 days of exposure to reduce symptoms, break transmission chains, and prevent loss of follow-up. This approach may lead to potential antibiotic overuse by uninfected individuals, thereby enhancing antimicrobial resistance. This study investigated the accuracy of epidemiological treatment for CT and NG.

Is Survival Impacted by One or Several Successive Cancers After Liver Transplantation? A French National Study.

Background And Aim: De novo cancers after liver transplantation (LT) are major causes of complications and mortality after LT. No report was found in the literature on several successive cancers (SSC). The aim of this study was to see if the survival of one or more cancers was different and to study the survival prognostic factors of patients with one cancer or SSC after LT.

Influence of the Surgeon's First Operation of the Day on Patient Outcomes.

Objective: To investigate whether the cumulative operative time spent by a surgeon operating on patients on the same day prior to starting a new procedure was associated with surgical outcomes.

Background: The impact of daily operating room workload on a surgeon's performance and patient outcomes is uncertain.

Methods: All elective patients, operated by attending surgeons across seven specialties in four French hospitals between 11/01/2020-12/31/2021, were included.

Introducing a Depressurization Step in Online LCxSFC Modulation.

New online LCxSFC valve technologies have recently been developed, based on the transfer of the first-dimension eluent either in the CO stream or in the cosolvent stream of the SFC dimension. While using the appropriate valve configuration greatly improved peak shapes, the reduction of the analysis time remained a challenge. A compromise between high first-dimension flow rate, to reduce gradient time, and low second-dimension injected volume, to limit injection effects, is to implement a flow split upstream of the valve.

Guidance framework to apply best practices in ecological data analysis: lessons learned from building Galaxy-Ecology.

Numerous conceptual frameworks exist for best practices in research data and analysis (e.g., Open Science and FAIR principles).

Cognitive Remediation for Adolescents With Mental Health Disorders: A Systematic Review and Meta-Analysis.

Introduction: The effects of cognitive remediation therapy (CRT) in adults with mental health disorders have been widely documented, but its effects in adolescents with mental health disorders remain poorly understood. This review aims to (1) determine the effects of CRT on cognition, symptoms and functioning for adolescents with mental health disorders and (2) evaluate the methodological quality of studies on CRT.

Methods: A systematic review and meta-analysis were conducted of randomised controlled trials of CRT involving adolescents with mental health disorders.

Determining the influence of an intervention of stress management on medical students' levels of psychophysiological stress: the protocol of the PROMESS-Stress clinical trial.

Background: Medical students face highly competitive stressful situations throughout their curriculum, which can lead to elevated stress levels and a major decline in quality of life, well-being, learning abilities, and health. It is crucial to assist medical students in coping with these stressful situations during their curriculum.

Methods: The PROMESS-Stress clinical trial aims to support future healthcare professionals by enhancing their abilities to manage stressful situations.

The PENDOR study: establishment of a panel of patient-derived tumor organoids from endometrial cancer to assess efficacy of PARP inhibitors.

Background: Combination of chemotherapy and immunotherapy is the current standard of care for advanced endometrial cancer. However, survival outcome remains poor, highlighting the urgent need for new treatments and reliable tools to identify patients who will benefit from them. Patient-Derived Tumor Organoids (PDTO) are three-dimensional structures established from patient tumors, and are closely mimicking the features of the tumor of origin.

Mitochondria dysfunction, a potential cytoprotection target against ischemia-reperfusion injury in a mouse stroke model.

More than 50 ​% of patients undergoing mechanical thrombectomy (MT) for ischemic stroke have a poor functional outcome despite timely and successful angiographic reperfusion, highlighting the need for adjunctive treatments to reperfusion therapy. Mitochondria are key regulators of cell fate, by controlling cell bioenergetics via oxidative phosphorylation (OXPHOS) and cell death through the mitochondrial permeability transition pore (mPTP). Whether these two main mitochondrial functions are altered by reperfusion and could represent a new cytoprotective approach remains to be elucidated in mice.

Robust deep learning from weakly dependent data.

Recent developments on deep learning established some theoretical properties of deep neural networks estimators. However, most of the existing works on this topic are restricted to bounded loss functions or (sub)-Gaussian or bounded variables. This paper considers robust deep learning from weakly dependent observations, with unbounded loss function and unbounded output.

A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium.

Low-intensity Transcranial Ultrasonic Stimulation (TUS) is a non-invasive brain stimulation technique enabling cortical and deep brain targeting with unprecedented spatial accuracy. Given the high rate of adoption by new users with varying levels of expertise and interdisciplinary backgrounds, practical guidelines are needed to ensure state-of-the-art TUS application and reproducible outcomes. Therefore, the International Transcranial Ultrasonic Stimulation Safety and Standards (ITRUSST) consortium has formed a subcommittee, endorsed by the International Federation of Clinical Neurophysiology (IFCN), to develop recommendations for best practices in human TUS applications.

Assessing the Risk of Relapse After In Vitro Fertilization in Women With Multiple Sclerosis.

Background And Objectives: Older studies reported an increased risk of relapse after in vitro fertilization (IVF) in women with multiple sclerosis (MS), which has not been confirmed by more recent works. All these studies had several limitations, such as small sample sizes, absence of a control population, or lack of neurologic validation of the relapses. The aim of this study was to determine the risk of relapse after IVF in women with MS.

NK Cell Immaturity and NKp30 Expression Positively Correlate with Clinical Outcome in Multiple Myeloma Patients from the IFM2009 Clinical Trial.

Multiple myeloma (MM) is a proliferation of tumoral plasma cells that is still incurable. Natural killer (NK) cells can recognize and kill MM cells in vitro. However, previous literature suggests an alteration of NK cell function in MM patients.

Variation in the fitness impact of translationally optimal codons among animals.

Early studies in invertebrate model organisms (fruit flies, nematodes) showed that their synonymous codon usage is under selective pressure to optimize translation efficiency in highly expressed genes (a process called translational selection). In contrast, mammals show little evidence of selection for translationally optimal codons. To understand this difference, we examined the use of synonymous codons in 223 metazoan species, covering a wide range of animal clades.

Exogenous-Endogenous Surfactant Interaction Yields Heterogeneous Spreading in Complex Branching Networks.

Experiments have shown that surfactant introduced to a liquid-filled maze can find the solution path. We reveal how the maze-solving dynamics arise from interactions between the added surfactant and endogenous surfactant present at the liquid surface. We simulate the dynamics using a nonlinear model solved with a discrete mimetic scheme on a graph.

Micromolar Concentration Affinity Study on a Benchtop NMR Spectrometer with Secondary C Labeled Hyperpolarized Ligands.

Benchtop NMR is becoming an increasingly important tool, sometimes providing a simple and low-cost alternative to high-field NMR. The Achilles heel of NMR and even more critically of benchtop NMR is its limited sensitivity. However, when combined with hyperpolarization techniques, the sensitivity boost can provide excellent sensitivity that can even make benchtop NMR compatible with affinity studies for drug discovery.

Enhancing fluorescence correlation spectroscopy with machine learning to infer anomalous molecular motion.

The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as "anomalous diffusion." To study this phenomenon in living cells, fluorescence correlation spectroscopy (FCS) and single-particle tracking (SPT) are the two main methods of reference. In opposition to SPT, FCS, with its classical analysis methodology, cannot consider models of motion for which no analytical expression of the auto-correlation function is known.

Bone mineral density in French adults with early-treated phenylketonuria.

Phenylketonuria (PKU) treatment requires a low-phenylalanine (Phe) diet limiting natural protein intake, using medical low-protein foods and Phe-free amino acids (AA) supplements along with micronutriments' supplies. Current recommendations suggest maintaining this diet for life to prevent neuro-psychological effects of high Phe concentrations. The long-term consequences of such a diet are poorly understood, particularly on bone health.

Biomechanical properties of ovarian tissue and their impact on the activation of follicular growth: a narrative review.

Follicular recruitment is tightly regulated to ensure long-term balance between the pools of dormant and growing follicles. While the growth of secondary to antral follicles is well understood, the initiation of folliculogenesis remains elusive. Several processes have been described, and a new approach is mechanotransduction.

Exploring Dynamic Brain Oscillations in Motor Imagery and Low-frequency Sound.

Although both motor imagery (MI) and low-frequency sound listening have independently been shown to modulate brain activity, the potential synergistic effects that may arise from their combined application remains unexplored. Any further modulation derived from this combination may be relevant for motor learning and rehabilitation. We probed neurophysiological activity during these two processes, measuring alpha and beta band power amplitude by means of EEG recordings.

Passive hamstring muscles rigidity throughout the menstrual cycle and the effect of oral contraception.

Objectives: Female athletes have a lower risk of hamstring strain injuries than males. The variations in oestradiol and progesterone concentrations happening during the menstrual cycle and oral contraceptive use may influence muscle mechanical properties, potentially affecting muscle injury risk. However, to date, no study has combined an assessment of hamstring muscles' mechanical properties spread over the full knee range of motion with rigorous hormonal control of the menstrual cycle, electromyographic monitoring and inclusion of oral contraceptive users.