Comparing the capacity of intraoral scanner and expert scoring in detecting potential deviations in guided endodontics: an in vitro study.

Introduction: Guided endodontics recently offers a conservative solution for conducting root canal treatment in cases of obliterated canals, but guide mispositioning remains a challenge. Recently, intraoral scanners (IOS) were proposed to detect deviations, but their effectiveness compared to expert visual assessments during guide insertion is uncertain. The objective of the present study was to primarily compare the risk of deviation predicted by an IOS versus expert assessment and secondarily identify factors influencing this risk.

Human cortical bone intrinsic permeability distribution based on 3D canalicular morphology.

Bone permeability is a key parameter that drives osteocyte-based mechanobiological modelling and remodelling. While previous experimental and numerical studies have estimated bone permeability based on the morphology of the lacuno-canalicular network, these studies often relied on simplified geometries. In the current study, bone permeability was characterized using more realistic canalicular geometry for the morphological data.

Prediction of relapse in a French cohort of outpatients with schizophrenia (FACE-SZ): Prediction, not association.

Background: Schizophrenia (SZ) commonly manifests through multiple relapses, each impeding the path to recovery and incurring personal and societal costs. Despite the identification of various risk factors associated to the risk of relapse, the development of accurate algorithms predictive of relapse has been limited, partly due to inadequate statistical methods. Additionally, despite the wealth of data showing strong associations between inflammation and schizophrenia, the two existing studies failed to demonstrate whether inflammatory parameters could predict relapse.

In vitro activity of rifampicin, rifapentine and rifabutin in combination with their 25-deacetyl-metabolites against various Mycobacterium tuberculosis lineages.

Objectives: Rifamycin agents (rifampicin (RIF), rifapentine (RFP), rifabutin (RFB)) are the cornerstone of tuberculosis (TB) therapy. Rifamycins are metabolized into 25-deacetyl-metabolites, which have been described has active and may contribute to in vivo drug effect. However, little is known about the combined effect of rifamycins and their metabolites across different Mycobacterium tuberculosis complex (MTBC) lineages.

Associations between dietary diversity and self-rated health in a transverse study of four local food systems (French Guiana, Guadeloupe, Portugal and Senegal).

Background: The nutrition transition is linked to the double-burden of malnutrition worldwide, and its impact on the quality of life is considerable. The dietary diversity score and self-rated health are two proxies that have been used to assess, for the former, nutrient adequacy and overall diet quality, and for the latter, health from a sociological, epidemiological and economical lens. The general aim of this study was to evaluate the relation between food and subjective health, and to test the hypothesis that greater dietary diversity is positively associated with a better perception of health.

Drosophila Alms1 proteins regulate centriolar cartwheel assembly by enabling Plk4-Ana2 amplification loop.

Centrioles play a central role in cell division by recruiting pericentriolar material (PCM) to form the centrosome. Alterations in centriole number or function lead to various diseases including cancer or microcephaly. Centriole duplication is a highly conserved mechanism in eukaryotes.

[Ethical issues in long-term follow-up of pediatric cancers].

Introduction: Advances in knowledge about late effects of childhood cancer treatments have led to implement long-term follow-up care. This raises the question of the ethical issues involved in providing information to survivors, and in proposals for long-term follow-up consultations.

Method: We conducted a two-part qualitative study: (1) A semi-directive interview survey to explore survivors' experiences of medical proposals for follow-up consultations; (2) The creation of a multidisciplinary ethical reflection group aimed at identifying the ethical issues associated with the systematization of follow-up care.

Atoms as Electron Accelerators for Measuring the Cross Section of e^{+}e^{-}→Hadrons.

The hadronic vacuum polarization contribution to (g-2)_{μ} can be determined via dispersive methods from e^{+}e^{-}→hadrons data. We propose a novel approach to measure the hadronic cross section σ_{had}(s) as an alternative to the initial-state radiation and energy scan techniques, which relies on positron annihilation off atomic electrons of a high Z target (^{238}U, Z=92). We show that by leveraging the relativistic electron velocities of the inner atomic shells, a high-intensity 12 GeV positron beam, such as the one foreseen at JLab, can allow measuring σ_{had}(s) with high statistical accuracy from the two-pion threshold up to above sqrt[s]∼1  GeV.

Value of non-invasive test dynamics in guiding HCC surveillance decisions after HCV cure in patients with cirrhosis.

Background And Aims: The objective was to describe the dynamics of noninvasive tests (NITs) in cirrhotic patients following sustained virological response (SVR) and to assess their correlation with hepatocellular carcinoma (HCC) risk.

Methods: The dynamics of NITs (Fib4, APRI and LSM) were described in patients with cirrhosis after SVR included between 2006 and 2015 in two prospective French multicentre cohorts (ANRS CO22 Hepather and CO12 CirVir). To assess their relationship with the risk of HCC, a joint modeling approach was employed using both standard and flexible models adjusted for age and sex.

Effect of the aspect ratio and wall heterogeneities on the mechanical behaviour of the aneurysm wall: Experimental investigation on phantom arteries.

The management of unruptured intracranial aneurysms (UIA) involves assessing the risk of rupture, which requires a thorough understanding of risk factors such as the geometric characteristics of the neck (neck size) or local structural heterogeneities. This study explores the impact of neck size on the rupture risk of the aneurysmal sac and examines how local heterogeneities, such as calcifications or variations in tissue composition, influence the mechanical response of the wall of a saccular aneurysm during the insertion of an innovative arterial wall deformation device (DDP). The results reveal that high aspect ratios (AR) are associated with increased hemodynamic stress, thereby raising the risk of rupture.

Relationship between point-of-care ultrasound venous congestion assessment parameters, intravenous pressure, and venous return: a post-hoc analysis of a prospective cohort study.

Background: A recent study suggested that point-of-care ultrasound (POCUS) venous congestion assessment poorly describes the changes in venous return during a fluid challenge. The aim of the present study was to explore the relationship between POCUS venous congestion assessment parameters and the determinants of venous return in steady state and during a fluid challenge.

Methods: This study is a post-hoc analysis of a single-centre prospective cohort study of patients presenting acute circulatory failure and venous congestion.

Turing patterns on polymerized membranes: coarse-grained lattice modelling with an internal degree of freedom for polymer direction.

We numerically study Turing patterns (TPs) on two-dimensional surfaces with a square boundary in using a surface model for polymerized membranes. The variables used to describe the membranes correspond to two distinct degrees of freedom: an internal degree of freedom for the polymer directions in addition to the positional degree of freedom. This generalised surface model enables us to identify non-trivial interference between the TP system and the membranes.

Modulating the surface chemistry of gold nanoparticles produced laser ablation in liquids by favored oxidative processes in the presence of Br anions.

In this study, we explore the influence of bromide anions concentration on the surface chemistry of colloidal gold nanoparticles synthesized pulsed laser ablation in liquids (PLAL). Using X-ray photoelectron spectroscopy (XPS) in a controlled environment, by probing a beam of free-standing gold nanoparticles, we quantitatively characterize the surface composition of the nanoparticles, revealing that bromide adsorption significantly contributes to surface oxidation independently of counterion type and pH for alkaline solution. Additionally, our findings demonstrate the adjustability of halogen coverage post-synthesis, offering a versatile method for controlling nanoparticle properties.

A Temporal Graph Dataset of Bitcoin Entity-Entity Transactions.

Research on Bitcoin (BTC) transactions is a matter of interest for both economic and network science fields. Although this cryptocurrency is based on a decentralized system, making transaction details freely accessible, making raw blockchain data analyzable is not straightforward due to the Bitcoin protocol specificity and data richness. To address the need for an accessible dataset, we present ORBITAAL, the first comprehensive dataset based on temporal graph formalism.

DiCART device to measure capillary refill time: a validation study in patients with acute circulatory failure.

Capillary Refill Time (CRT) is a valuable metric to assess cutaneous perfusion. Its prognostic value in patients with acute circulatory failure has been reported as improved when the measurement is standardized. The DiCART™ device is a fully automated CRT measurement tool requiring validation.

[Clinical research in oncology in French Overseas Territories: Challenges, strengths, and available resources].

Introduction: Reducing territorial inequalities in access to care and innovations in oncology is an objective of the ten-year strategy to fight cancer. The populations of Overseas Territories (OT) face limits in terms of access to clinical research in oncology (CRO).

Methods: The article aims to share an exhaustive inventory of the challenges observed in the development of CRO in the OT but also the means identified to respond to them, illustrated with recent successes in terms of setting up a CRO program.

Nutritional value of organic food in children.

In Europe, organic food must comply with specific regulations which do not include nutritional criteria. The ability of organic food to meet the nutritional needs of children is not assessed. This narrative review discusses the nutritional composition (macronutrients, micronutrients) of organic food compared to conventional products and its clinical relevance with a pediatric focus, and the health impact of these differences and of contaminants which interfere with metabolism.

Multiparametric MRI: can we assess renal function differently?

We are lacking tools to evaluate renal performance. In this review, we presented the current knowledge and potential future applications in nephrology of new magnetic resonance imaging (MRI) techniques, focusing on diffusion-weighted (DWI) MRI, blood oxygen level-dependent (BOLD) MRI, and magnetic resonance relaxometry (T1 and T2 mapping). These sequences are sensitive to early changes in biological processes such as perfusion, oxygenation, edema, or fibrosis without requiring contrast medium injection and avoids irradiation and nephrotoxicity.

DYRK1A Up-Regulation Specifically Impairs a Presynaptic Form of Long-Term Potentiation.

Chromosome 21 DYRK1A kinase is associated with a variety of neuronal diseases including Down syndrome. However, the functional impact of this kinase at the synapse level remains unclear. We studied a mouse model that incorporated YAC 152F7 (570 kb), encoding six chromosome 21 genes including .

Pressure-induced amorphous-amorphous transition in pre-densified silica glass: an experimental exploration of the potential energy landscape.

Despite the difficulty of experimentally studying polyamorphic transitions in high-Tg glasses, it is well known that silica glass has two high-density phases: the cold-compressed and hot-compressed high-density amorphous phases (c-HDA and h-HDA). By means of vibrational spectroscopy techniques under pressure, we first evidence that the yield strength under hydrostatic pressure is identical for glasses of similar density, whatever the thermo-mechanical history, showing that the elastic limit of a silica glass depends solely of its density. Our results also reveal the changes in the energy landscape of amorphous silica under high pressure.

Increasing Participation and Completion Rates in Questionnaire Surveys of Primary Care Patients: Cluster-Randomized Study.

Background: Participation and completion rates in questionnaire-based surveys are often low.

Objective: This study aims to assess participation and completion rates for a survey using paper and mixed mode questionnaires with patients recruited by research assistants in primary care waiting rooms.

Methods: This cluster-randomized study, conducted in 2023 in France, involved 974 patients from 39 practices randomized into 4 groups: "paper with incentive" (n=251), "paper without incentive" (n=368), "mixed mode with tablet" (n=187), and "mixed mode with QR code" (n=168).

Abnormal Brain MRI in Anti-NMDA Receptor Encephalitis: Clinical and Prognostic Implications.

Background And Objectives: Abnormal brain MRI is associated with poor outcomes in anti-N-methyl-d-aspartate receptor encephalitis (NMDARE). We aimed to characterize the lesions on brain MRI in NMDARE and to assess the clinical and prognostic associations.

Methods: This retrospective cohort study included patients with NMDARE identified at the French Reference Center for Autoimmune Encephalitis, with at least a one-year follow-up, and with available brain MRI results.

Cryoconcentration of olive mill wastewater for application in leather tanning process: an alternative end to protect the environment and save raw materials consumption.

The aim of this work is the cryoconcentration of olive mill wastewater (OMW) to produce highly concentrated polyphenols solutions that can be applied in the tanning industry. The treatment by cryoconcentration consists of four steps: cooling, freezing, sweating, and melting. The operation purifies the ice in depth by partially melting the impure zones trapped in the pockets of concentrated solutions formed in the ice.

Traffic collisions and micromobility: A comparison between personal mobility devices and bicycles based on police reports.

Introduction: The recent increase in the use of bicycles and personal mobility devices (PMDs), including mostly E-scooters, is associated with a rapid rise in injuries. Understanding the main crash scenarios leading to these injuries is essential to evaluate and improve preventive and protective measures, especially for PMDs, which are often equated with bicycles. The objective of this study is to identify and compare the most common two-party collision scenarios for bicycles and PMDs, and to identify factors affecting injury severity.