Discrete Synaptic Events Induce Global Oscillations in Balanced Neural Networks.

Despite the fact that neural dynamics is triggered by discrete synaptic events, the neural response is usually obtained within the diffusion approximation representing the synaptic inputs as Gaussian noise. We derive a mean-field formalism encompassing synaptic shot noise for sparse balanced neural networks. For low (high) excitatory drive (inhibitory feedback) global oscillations emerge via continuous or hysteretic transitions, correctly predicted by our approach, but not from the diffusion approximation.

Cyclosporine A Delays the Terminal Disease Stage in the Tfam KO Mitochondrial Myopathy Mouse Model Without Improving Mitochondrial Energy Production.

Introduction And Aims: Mitochondrial myopathies are rare genetic disorders for which no effective treatment exists. We previously showed that the pharmacological cyclophilin inhibitor cyclosporine A (CsA) extends the lifespan of fast-twitch skeletal muscle-specific mitochondrial transcription factor A knockout (Tfam KO) mice, lacking the ability to transcribe mitochondrial DNA and displaying lethal mitochondrial myopathy. Our present aim was to assess whether the positive effect of CsA was associated with improved in vivo mitochondrial energy production.

Optimal dosage regimens of cefiderocol administered by short, prolonged or continuous infusion: a PK/PD simulation study.

Background And Objectives: Cefiderocol approved dosages are based on a prolonged infusion (PI) of 3 h that may not be adequate in all settings The objective of this study was to identify alternative cefiderocol dosage regimens based on short infusion (SI) or continuous infusion (CI).

Methods: We performed 1000-patient pharmacokinetic/pharmacodynamic (PK/PD) simulations based on a reference population model. Drug penetration into the epithelial lining fluid (ELF) was considered for pneumonia.

How can the reform of the activity-based payment system (T2A) help in financing innovative health products?

In France, the short-stay activities of public and private sector healthcare facilities have been financed since 2004 by activity-based pricing (T2A). The principle is to allow for payment determined primarily by the nature and volume of activities. T2A has enabled a major transformation compared to the old financing system, chiefly for public sector facilities that used to operate under a general allocation, and convergence between payment methods in the public and private sectors.

Muscle composition is not a prognostic factor for muscle strength recovery after anterior cruciate ligament surgery by hamstring tendon autograft.

Purpose: For the athlete, anterior Cruciate Ligament (ACL) rupture and its surgical management are often a turning point in their career. Success and time to return to sport are essential parameters for athletes and their support staff, so it is critical to understand the prognostic factors influencing return to sport after anterior cruciate ligament reconstruction (ACLR). The aim of this study was to determine the influence of hamstring muscle composition on muscle power following ACLR with autogenous hamstring grafts.

In patients with asthma, obesity status is associated with poor control and high exacerbation rates, which are reversed after bariatric surgery.

Background: In asthma, obesity status is associated with poor control and high exacerbation rates. The primary objective was to determine the effect of bariatric surgery (BS) on asthma control and exacerbations.

Methods: Retrospective study with a 3-year cohort of obese patients before and after BS: a baseline period (P0) covering the 12 months before BS and P1 and P2 periods covering the first and second years after BS, respectively.

Factors influencing the turnover of nurses in French intensive care unit-A multicenter interview survey.

Background: Nurse retention is a major concern in healthcare settings, especially among intensive care units (ICU), in which nurses are highly specialized. The objective was to describe the nurse courses after their entrance into the ICU, their motivation for leaving the ICU, and to identify the independent factors that influenced the nurse resignation from their units.

Methods: In 3 different centers, every ICU nurse working between 2013 and 2023 was telephonically contacted and was asked to describe their career and, when appropriate, the reasons that influenced their resignation from their units; they rated on a Likert scale of 14 factors that influenced their decision.

Mycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient.

This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spacer region. Long-term treatment with caspofungin for previous candidemia likely promoted the dissemination of this intrinsically echinocandin-resistant fungus from colonization sites in the lungs and rectal area.

Impact of pH on sodium caseinate binding and structural changes on montmorillonite surface.

The immobilization of proteins onto clay surfaces has proven beneficial for pharmaceutical and environmental applications. This study examines the adsorption of sodium caseinate (Cas), an amphiphilic protein widely used in pharmaceutical formulations, onto sodium montmorillonite (Mt). Adsorption isotherms and kinetics were examined at two pHs, above and below Cas isoelectric point (IEP).

De-escalating and discontinuing disease-modifying therapies in multiple sclerosis.

The development of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS) has been highly successful in recent decades. It is now widely accepted that early initiation of DMTs after disease onset is associated with a better long-term prognosis. However, the question of when and how to de-escalate or discontinue DMTs remains open and critical.

Fatigue-induced changes in electromyographic activity after repeated racing turns: a pilot study.

Purpose: Alpine skiing races are physically demanding events characterized by numerous repeated near-maximal activations of the lower limb muscles. Although this type of task is known to induce neuromuscular fatigue, electromyographic activity (EMG) adaptations after repeated maximal-intensity skiing have not been previously investigated.

Methods: Six skiers completed a 6-turns section with (FAT) and without performing 30 giant slalom (GS) turns (CONT).

Neural networks for predicting etiological diagnosis of uveitis.

Background/objectives: The large number and heterogeneity of causes of uveitis make the etiological diagnosis a complex task. The clinician must consider all the information concerning the ophthalmological and extra-ophthalmological features of the patient. Diagnostic machine learning algorithms have been developed and provide a correct diagnosis in one-half to three-quarters of cases.

Primary central nervous system lymphoma of the spinal cord: A LOC network cohort study.

Purpose: Primary central nervous system lymphoma (PCNSL) mainly affects the brain (>90% cases); there are very little data pertaining to PCNSL involving the spinal cord.

Methods: We retrospectively selected from the French LOC network database adult immunocompetent patients diagnosed with PCNSL involving the spinal cord between 2011 and 2022.

Results: Of the 2043 patients records retrieved from the database, 16 patients (median age: 62.

Revealing the composition and optical properties of marine carbonaceous aerosols: A case of the eastern China marginal seas.

Marine aerosols are major components of atmospheric aerosols, playing substantial roles in influencing the regional and global environment and climate. Marine aerosols are not only produced by seawater directly, but also by indirect processes such as atmospheric oxidation of marine bioactive gases as well as terrestrial transport. Over the Eastern China Marginal Seas (ECMS), marine aerosols are strongly affected by marine emission and transport of terrestrial aerosols.

Guidelines for cerebrovascular segmentation: Managing imperfect annotations in the context of semi-supervised learning.

Segmentation in medical imaging is an essential and often preliminary task in the image processing chain, driving numerous efforts towards the design of robust segmentation algorithms. Supervised learning methods achieve excellent performances when fed with a sufficient amount of labeled data. However, such labels are typically highly time-consuming, error-prone and expensive to produce.

PAM-13 in clinical cancer care: A systematic review.

Background: The Patient Activation Measure-13 (PAM-13) assesses patients' ability to manage their healthcare. This systematic review aimed to summarize the relationship between the PAM-13 and patient characteristics, as well as program effectiveness.

Methods: A systematic literature search was conducted using the PubMed database and following the PRISMA guidelines.

Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial.

Background And Objectives: Data from randomized trials on the treatment effect of pure thrombolysis in patients with vessel occlusion are lacking. We examined data from a corresponding subsample of patients from the multicenter, randomized, placebo-controlled WAKE-UP trial to determine whether MRI-guided IV thrombolysis with alteplase in unknown-onset ischemic stroke benefits patients presenting with vessel occlusion.

Methods: Patients with an acute ischemic lesion visible on MRI diffusion-weighted imaging but no marked parenchymal hyperintensity on fluid-attenuated inversion recovery images were randomized to treatment with IV alteplase or placebo.

Loss of Sult1a1 reduces body weight and increases browning of white adipose tissue.

Background And Objective: Overweight and obesity affects millions of individuals worldwide and consequently represents a major public health concern. Individuals living with overweight and obesity have difficulty maintaining a low body weight due to known physiological mechanisms which prevent further weight loss and drive weight regain. In contrast, mechanisms which promote low body weight maintenance receive less attention and are largely unknown.

Human Endogenous Retroviruses Expression in Autoimmunity.

In relation to ancient infections, a substantial number of retroviral sequences with persistent immunogenic potential were integrated within the human genome (HERVs). Under physiological conditions, coding sequences from HERVs can participate in cell/tissue homeostasis and physiological functions in an epigenetically controlled manner. However, HERV expression is susceptible to contribute to various pathologies, including autoinflammatory and autoimmune disorders, when reprogrammed by exogenous stimuli such as drugs or microbial infections.

Changes in Respiratory Syncytial Virus-Associated Hospitalisations Epidemiology After Nirsevimab Introduction in Lyon, France.

Background: Respiratory Syncytial Virus (RSV) is a major health concern, particularly for infants. In France, Nirsevimab, a long-acting monoclonal antibody to prevent RSV-associated lower respiratory tract infections (LRTI) was available from September 2023. We described RSV-associated LRTI hospitalisations during the 2023-2024 season among infants younger than six months born at the Hospices Civils de Lyon (HCL), and evaluated the effectiveness of Nirsevimab against RSV-LRTI hospitalisation.

A modular machine learning tool for holistic and fine-grained behavioral analysis.

Artificial intelligence techniques offer promising avenues for exploring human body features from videos, yet no freely accessible tool has reliably provided holistic and fine-grained behavioral analyses to date. To address this, we developed a machine learning tool based on a two-level approach: a first lower-level processing using computer vision for extracting fine-grained and comprehensive behavioral features such as skeleton or facial points, gaze, and action units; a second level of machine learning classification coupled with explainability providing modularity, to determine which behavioral features are triggered by specific environments. To validate our tool, we filmed 16 participants across six conditions, varying according to the presence of a person ("Pers"), a sound ("Snd"), or silence ("Rest"), and according to emotional levels using self-referential ("Self") and control ("Ctrl") stimuli.

Metacognition biases information seeking in assessing ambiguous news.

How do we assess the veracity of ambiguous news, and does metacognition guide our decisions to seek further information? In a controlled experiment, participants evaluated the veracity of ambiguous news and decided whether to seek extra information. Confidence in their veracity judgments did not predict accuracy, showing limited metacognitive ability when facing ambiguous news. Despite this, confidence in one's judgment was the primary driver of the demand for additional information about the news.

Congenital toxoplasmosis: Fewer clinical signs at 3 years of age over the last 15 years but stable risk of materno-fetal transmission.

Risk and severity of congenital toxoplasmosis were estimated using data from 2,455 consecutive mother/child pairs. Clinical signs at 3 years were halved in the 177 children born since 2009 compared to 1996-2008 (OR=0.49; 95% Confidence interval 0.

Does what we find depend on how we sample? Measured streambed microplastic concentrations can be affected by the choice of sampling method.

Microplastics (MPs) are prevalent in rivers worldwide and can adversely impact riverine ecosystems. To sample for MPs in streambeds, a variety of different sampling techniques is applied, including (i) scooping, (ii) coring, (iii) freeze coring, (iv) resuspension method, and (v) piezometer sampling. These common sampling techniques capture different parts of the streambed and different sampling volumes.