3,773 results match your criteria: "Universite Bordeaux[Affiliation]"

Deep crustal production of hydrogen (H) is a potential source of primary energy if recoverable accumulations in geological formations are sufficiently large. We report direct measurements of an elevated outgassing rate of 84% (by volume) of H from the deep underground Bulqizë chromite mine in Albania. A minimum of 200 tons of H is vented annually from the mine's galleries, making it one of the largest recorded H flow rates to date.

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Article Synopsis
  • Hepatocellular adenomas (HCAs) are rare benign liver tumors with different subtypes linked to various mutation risks for malignant transformation, particularly the β-catenin-activated subtypes.
  • * A study revealed that the tumor rim exhibits increased glutamine synthetase and distinct vascular features compared to the tumor center, potentially indicating tumor heterogeneity.
  • * Using advanced imaging and analysis techniques, researchers found that while both tumor regions share the same mutations, their protein expressions differ significantly, suggesting that factors other than mutational status contribute to their varied characteristics.
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Evidence from personal ornaments suggest nine distinct cultural groups between 34,000 and 24,000 years ago in Europe.

Nat Hum Behav

March 2024

CNRS UMR 5199 De la Préhistoire à l'Actuel: Culture, Environnement, et Anthropologie (PACEA), Université Bordeaux, Bordeaux, France.

Article Synopsis
  • The study investigates the interplay between genetic and cultural evolution among European hunter-gatherers during the Gravettian period (34,000-24,000 years ago) using a new georeferenced dataset of personal ornaments.
  • Through advanced statistical analyses, the researchers found that the variability in these ornaments can't be solely explained by geographic distance, revealing nine distinct cultural groups across Europe.
  • The findings suggest a more intricate relationship between cultural diversity and genetic ancestry, indicating that some cultural entities exist in regions lacking genetic data while others are closely related to genetically similar populations.
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Acceleration and transport of relativistic electrons in the jets of the microquasar SS 433.

Science

January 2024

Centre for Space Research, North-West University, Potchefstroom 2520, South Africa.

SS 433 is a microquasar, a stellar binary system that launches collimated relativistic jets. We observed SS 433 in gamma rays using the High Energy Stereoscopic System (H.E.

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Aging is characterized by a decline in social behavior and cognitive functions leading to a decrease in life quality. In a previous study, we show that a fish hydrolysate supplementation prevents age-related decline in spatial short-term memory and long-term memory and anxiety-like behavior and improves the stress response in aged mice. The aim of this study was to determine the effects of a fish hydrolysate enriched with EPA/DHA or not on the cognitive ability and social interaction during aging and the biological mechanisms involved.

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Transient power dynamics in nematic electroconvection.

Chaos

December 2023

Department of Physics and Astronomy, George Mason University, Fairfax, Virginia 22030, USA.

We have observed the transient dynamics in nematic electroconvection during a sudden change in the driving voltage. The steady state dynamics of nematic electroconvection during a constant driving voltage are well characterized examples of spatiotemporal chaos, and thus are useful for the study of chaotic transients. For a set of starting conditions, we were able to show that the system can enter a long-lived transient state with a larger power dissipation rate.

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Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK.

Schizophr Res

June 2024

Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address:

Background: Pharmacovigilance studies indicate clozapine history is marked by adverse drug reactions (ADRs).

Objective: In a 2021 article, the United Kingdom (UK) had >90 % of European clozapine-related fatal outcomes in VigiBase, the World Health Organization's pharmacovigilance database. Two possibly opposing hypotheses could explain this disparity: 1) fewer reported fatal outcomes in other Western European countries mainly reflect underreporting to VigiBase, and 2) the higher number of UK reports reflects higher real relative mortality.

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Reply: The Mechanism of Brugada Syndrome: Is it Induced Only by Conduction Disturbance?

JACC Clin Electrophysiol

November 2023

IHU LIRYC, L'Institut de Rythmologie et Modélisation Cardiaque, Fondation Bordeaux Université, Bordeaux, France; Université Bordeaux, Inserm, Centre de Recherche Cardio-Thoracique de Bordeaux U1045, Bordeaux, France.

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The article introduces the enhancements made to the IsoArcH database for isotope paleopathology. This includes the addition of new metadata fields, which allow for describing abnormal anatomical or physiological conditions in humans and animals at either the individual or sample level. To showcase the novel features of the database, the article features a unique dataset of carbon and nitrogen isotope values obtained on bulk bone collagen from 42 clinically-documented cases of the Jedlička pathological-anatomical reference collection, dating from the 19th century CE and curated at the National Museum in Prague, Czechia.

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Re-examination of the Subalyuk Neanderthal remains uncovers signs of probable TB infection (Subalyuk Cave, Hungary).

Tuberculosis (Edinb)

December 2023

Department of Biological Anthropology, Institute of Biology, University of Szeged, Közép fasor 52, H-6726, Szeged, Hungary; Department of Anthropology, Hungarian Natural History Museum, Budapest, Hungary; Department of Biological Anthropology, Eötvös Loránd University, Budapest, Hungary. Electronic address:

In 1932, skeletal remains of two Neanderthal individuals, a young adult female and a 3-4-year-old child, were discovered in Subalyuk Cave in Northern Hungary [1,2]. Results of the anthropological examination were published some years after this important discovery. Methodological progress encouraged re-examination of the material during the last few years.

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Kidney Function Decline and Serious Adverse Drug Reactions in Patients With CKD.

Am J Kidney Dis

May 2024

Pharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens-Picardie University Medical Center, Amiens; MP3CV Laboratory, Jules Verne University of Picardie, Amiens. Electronic address:

Rationale & Objective: Adverse drug reactions (ADRs) are common in patients with chronic kidney disease (CKD). The impact of kidney function decline on serious ADR risk has been poorly investigated. We comprehensively describe ADRs and assess the relationship between estimated glomerular filtration rate (eGFR) and serious ADR risk.

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Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.

Elife

November 2023

Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Team Genetics Epigenetics and Therapies of Infertility, Grenoble, France.

Article Synopsis
  • * Researchers discovered homozygous variants linked to the condition in four unrelated patients, which disrupted the localization of certain proteins essential for sperm flagellum function.
  • * The study identified ZMYND12 as a new gene associated with asthenoteratozoospermia, which forms a complex with other proteins critical for sperm motility, affecting male fertility.
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Objective: Study the impact of 14th July 2016 Nice terrorist attack on Pediatric Emergency Department (PED) visits by youth under 18 years of age.

Methods: PED visits diagnoses (ICD10) were clustered and analyzed based on retrospective data from the syndromic surveillance system of the Children's university hospital of Nice (Southern France). The studied period ranges from 2013 to 2019, i.

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Critical Influence of Water on the Polymorphism of 1,3-Dimethylurea and Other Heterogeneous Equilibria.

Molecules

October 2023

Laboratoire Sciences et Méthodes Séparatives UR3233, Université Rouen Normandie, Normandie Université, F-76000 Rouen, France.

It is shown that the presence of hundreds of ppm of water in 1,3-dimethylurea (DMU) powder led to the large depression of the transition temperature between the two enantiotropically related polymorphic forms of DMU (Form II → Form I) from 58 °C to 25 °C, thus explaining the reported discrepancies on this temperature of transition. Importantly, this case study shows that thermodynamics (through the construction of the DMU-water temperature-composition phase diagram) rather than kinetics is responsible for this significant temperature drop. Furthermore, this work also highlights the existence of a monohydrate of DMU that has never been reported before with a non-congruent fusion at 8 °C.

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A wide variety of coils are available for vascular embolization. This study aimed to evaluate the safety and efficacy of a new Prestige coil. We carried out retrospective analysis of a multicenter's registry data collected between February 2022 and November 2022.

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Fluorinated species have a pivotal role in semiconductor material chemistry and some of them have been detected beyond the Earth's atmosphere. Achieving good energy accuracy on fluorinated species using quantum chemical calculations has long been a challenge. In addition, obtaining direct experimental thermochemical quantities has also proved difficult.

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Article Synopsis
  • Intensive insulin therapy is effective for managing diabetes but can lead to dangerous hypoglycemia, primarily detected by the ventromedial hypothalamus (VMH) in the brain.
  • The study aimed to explore the role of serotonin (5-HT) neurons in regulating the counter-regulatory response (CRR) to hypoglycemia.
  • Results indicated that insulin increases activity in dorsal raphe 5-HT neurons and affects glucagon secretion, highlighting a significant role of the serotonin network in responding to insulin-induced low blood sugar levels.
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Segment Anything by Meta as a foundation model for image segmentation: a new era for histopathological images.

Pathology

December 2023

ImmunoConcEpT, CNRS, Université Bordeaux, UMR 5164, Bordeaux, France; CHU de Bordeaux, Service de Néphrologie-Transplantation-Dialyse-Aphéréses, Hôpital Pellegrin, Bordeaux, France.

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We identify an acoustic process in which the conversion of angular momentum between its spin and orbital form takes place. The interaction between an evanescent wave propagating at the interface of two immiscible fluids and an isolated droplet is considered. The elliptical motion of the fluid supporting the incident wave is associated with a simple state of spin angular momentum, a quantity recently introduced for acoustic waves in the literature.

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Aims: The primary aim of this study was to evaluate the impact of drug consumption rooms (DCRs) in France on injection equipment-sharing, while the secondary aims focused upon their impact on access to hepatitis C virus (HCV) testing and opioid agonist treatment (OAT).

Design: The COhort to identify Structural and INdividual factors associated with drug USe (COSINUS cohort) was a 12-month longitudinal study of 665 people who inject drugs (PWID), conducted in Bordeaux, Marseille, Paris and Strasbourg. We used data from face-to-face interviews at enrolment and at 6-month and 12-month visits.

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The predicted increase of drought intensity in South-East Asia has raised concern about the sustainability of rubber (Hevea brasiliensis Müll. Arg.) cultivation.

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Update on the management of endometriosis-associated pain in France.

J Gynecol Obstet Hum Reprod

November 2023

C Chapron, Service de Chirurgie Gynécologique II et Médecine de la Reproduction, AP-HP, Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Université Paris-Cité, Faculté de Médecine Paris-Centre, Paris, France.

Article Synopsis
  • The French National College of Obstetricians and Gynecologists updated their guidelines in 2018 to manage endometriosis pain, now incorporating new therapies and research up to 2021.
  • A new diagnostic approach using patient questionnaires and saliva analysis may help identify pelvic pain issues without the need for surgery.
  • Dienogest (DNG) is recognized as an effective first-line treatment for endometriosis pain, and new oral GnRH antagonists are expected to hit the French market soon, offering rapid results with easier administration compared to existing treatments.
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Objective: We optimized the spectrophotometric micromethod for the determination of arginase activity based on the Corraliza et al. modification of Schimke's method. Arginase activity in sera from patients suffering from human African trypanosomiasis, in macrophage lysates from trypanosome-infected mice, and in purified bovine liver arginase was compared using the conventional and optimized micromethods.

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The "A Randomized Trial of Induction Versus Expectant Management" trial (ARRIVE trial) published in 2018 suggested that induction of labor can be considered a "reasonable option" for low-risk nulliparous women at ≥39 weeks of gestation. The study results led some professional societies to endorse the option for elective induction of labor at 39 weeks of gestation in low-risk nulliparas, and this has begun to change obstetrical practice. The ARRIVE trial provided valuable information supporting the benefits of induction of labor; however, the trial is insufficient to serve as the primary justification for widespread elective induction of labor at 39 weeks of gestation in low-risk nulliparas because of concerns about external validity.

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