2,381 results match your criteria: "Universitatsklinikum Freiburg[Affiliation]"

We report the case of a young patient with severe hypoxic brain injury after cardiopulmonary resuscitation, resulting in brain death/death by neurologic criteria (BD/DNC). Consistent with the patient's expressed wishes, treatment was sustained to facilitate organ donation. However, in the context of a severe post-resuscitation syndrome and physiological disturbances resulting from BD/DNC, refractory circulatory shock ensued.

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[What should be considered in the case of previous operations or injections prior to hip and knee replacement?].

Orthopadie (Heidelb)

January 2025

Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Deutschland.

Background: Patients who have had prior injections, surgeries such as arthroscopies, and have existing osteosynthetic implants in the hip and knee have an increased risk of periprosthetic infections when undergoing hip (THA) or total knee arthroplasty (TKA).

Osteosynthesis: For patients with osteosynthetic implants in the knee joint, a two-stage procedure (implant removal followed by TKA) is recommended based on the available literature and the high colonization rates. A two-stage procedure is also recommended for patients with hip implants.

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[Challenges in neuroprognostication after extracorporeal membrane oxygenation].

Med Klin Intensivmed Notfmed

January 2025

Interdisziplinäre Medizinische Intensivtherapie (IMIT), Universitätsklinikum Freiburg, Hugstetterstraße 55, 79106, Freiburg, Deutschland.

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[Treatment of geriatric odontoid fractures].

Unfallchirurgie (Heidelb)

January 2025

Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Freiburg, Hugstetter Straße 55, 79106, Freiburg, Deutschland.

The treatment of odontoid fractures in geriatric patients, particularly type II fractures, remains controversial. In biologically young patients, studies suggest advantages of surgical treatment in terms of mortality; however, this advantage is not observed in geriatric patients. While the mortality appears to be higher after conservative treatment in patients aged 65-80 years, there are studies that have shown no differences in mortality for patients aged 80 years or older and even showed advantages of conservative treatment in this age group.

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The question of whether scuba diving is safe for patients with a history of venous thromboembolism (VTE) remains unanswered. Cases of VTE have been reported after decompression accidents but not following properly conducted dives. However, the risk of VTE and bleeding on anticoagulant therapy during diving has yet to be defined.

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[Trauma of the midface : Symptoms, diagnostics and treatment].

Radiologie (Heidelb)

January 2025

Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Freiburg, Freiburg, Deutschland.

Midface fractures present a clinical challenge in otorhinolaryngology due to their often complex injury pattern and nonspecific symptoms. Precise diagnostics, including differentiated imaging procedures, are required. Interdisciplinary consultation between otorhinolaryngology, maxillofacial surgery, neurosurgery, and ophthalmology is often necessary.

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[Temporobasal meningioma as possible cause of a cognitive disturbance with depression in old age].

Nervenarzt

December 2024

Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 5, 79104, Freiburg, Deutschland.

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In Germany, a substantial reform of emergency care is strictly recommended. Regulation of patient flows into the ambulatory and stationary sectors remains a major issue.In the OPTINOFA project funded by Innovationsfunds, a new triage system was developed for a structured primary evaluation of both urgency and care level of emergency cases.

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Participation in the Clinic for Child and Adolescent Psychiatry and Psychotherapy. Do Personality Traits Affect the Difference Between the Desire and Experience of Participation? Participation and codetermination are important rights of children and adolescents. The present study examined discrepancies between the desire and experience of participation, their relationship with treatment satisfaction, and which patient-related variables are associated with the reported discrepancies.

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[Treatment of cancer-related pain-From pharmacotherapy to invasive procedures].

Anaesthesiologie

December 2024

Sektion Schmerzmedizin, Klinik für Anästhesiologie, Medizinische Fakultät Heidelberg, Universität Heidelberg, Heidelberg, Deutschland.

Depending on the stage of the tumor up to 80% of the patients suffer from cancer-related pain but treatment is often inadequate. Multiple causes can trigger pain and these can be due to the tumor itself, its secondary consequences but also treatment related. A differentiated assessment and individually tailored treatment of cancer-related pain not only improve the quality of life but also reduce the risk of pain chronification.

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[Measuring Attitudes towards Health Services Research among Representatives of German Rehabilitation Facilities: The REHA-KNOWS Study].

Rehabilitation (Stuttg)

December 2024

Sektion Versorgungsforschung und Rehabilitationsforschung, Institut für Medizinische Biometrie und Statistik, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg.

Purpose: The REHA-KNOWS study explores the perceptions of practice representatives of rehabilitation facilities in Southwest Germany regarding (healthcare) research and shows benefits and barriers in knowledge transfer from the perspective of practice. For this purpose, an instrument with 12 5-level items was developed, which is exploratively examined in this paper. The instrument includes statements on the benefits, costs and added value of rehabilitation research projects as well as on the framework conditions in the facilities.

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[Speech development test for 2-year-olds (2;0-2;11 years)-evaluation of multicentric data of children after bilateral cochlear implant treatment : A retrospective longitudinal study].

HNO

December 2024

Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Sektion Implant Centrum Freiburg (ICF), Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Elsässerstraße 2n, 79110, Freiburg, Deutschland.

Background: Age-appropriate speech development is a primary aim of the rehabilitation of children treated with cochlear implants (CI). Various assessment tools are available, including the speech development test for 2‑year-olds (SETK-2). All tests are normalized to normal-hearing children; additionally, results are evaluated according to age and the duration of CI (hearing age).

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Article Synopsis
  • Duchenne muscular dystrophy is a common genetic disease in children that results in loss of motor skills, heart issues, and respiratory challenges.
  • Respiratory care by pediatric pulmonologists is crucial, including lung function monitoring, sleep studies, and managing ventilation support.
  • The article highlights the importance of collaboration among specialists to improve the treatment and quality of life for children with neuromuscular diseases like Duchenne muscular dystrophy.
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[Interventional radiology - Training and career opportunities].

Radiologie (Heidelb)

January 2025

Klinik für Radiologie, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland.

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[Prioritization of research questions in health crises-presentation of a concept developed during the COVID-19 pandemic].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz

January 2025

Institut für Evidenz in der Medizin, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Deutschland.

In acute crises such as the COVID-19 pandemic, scientific questions need to be addressed quickly in order to protect the health of the population and to maintain the function of the healthcare system. The prevailing urgency and the large number of issues to be addressed, combined with the limitation of time, personnel, or monetary resources make prioritization indispensable. In the COVID-19 Evidence Ecosystem (CEOsys) project initiated by the University Medicine Network (NUM), a procedure for the rapid prioritization of questions was used specifically for evidence syntheses and clinical guideline recommendations, which was further developed in the follow-up project PREparedness and Pandemic Response in Germany (PREPARED).

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[Skin fragility].

Dermatologie (Heidelb)

December 2024

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

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Introduction: The aim of the study was to evaluate the effectiveness of cerclage in women with previous late miscarriages or premature births. The primary aim was to prolong pregnancy and achieve a term delivery. Secondarily, it was investigated whether an intervention after an early pathological 75-g-oGTT result influences these endpoints.

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An important prerequisite for ascertaining rational antibiotic prescribing is the availability and evaluation of antibiotic use data. In this study we report evolving trends of antibiotic use in German hospitals during the last decade.Using drug dispensing data from acute care hospital pharmacies, we calculated yearly antibiotic use density values for the period from 2012/13 through to 2021/22.

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[Genetic diseases with skin fragility in children].

Dermatologie (Heidelb)

December 2024

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

Article Synopsis
  • Genetic diseases that cause skin fragility are diverse in their symptoms and genetic causes, making it crucial for healthcare professionals to differentiate them from more common conditions like infections or burns.
  • The classification of these rare diseases is guided by their clinical presentation, histological characteristics, and genetic mutations, with most treatments being symptomatic rather than curative.
  • Advances in genetic testing have integrated the study of these rare diseases into everyday clinical practice, emphasizing the need for collaboration among specialists to ensure proper diagnosis and care for affected children.
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[Summary of the S1 guideline on sustainability in intensive care and emergency medicine].

Med Klin Intensivmed Notfmed

February 2025

Medizinische Fakultät und Uniklinik Köln, Klinik I für Innere Medizin, Centrum für Integrierte Onkologie Aachen Bonn Köln Düsseldorf, Universität zu Köln, Köln, Deutschland.

Background: Man-made climate change is one of the greatest challenges of the future. The course is being set in the current generation. As the healthcare sector contributes a considerable proportion of greenhouse gas emissions, measures to counteract this must be introduced as a matter of urgency.

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Background: The patterns and intensity of inpatient antibiotic prescribing vary according to medical specialty.

Objectives: Analysis of recent data on antibiotic use density in hospital departments of urology in Germany.

Methods: Annual surveillance data of 107 departments for the period 2022/2023 were evaluated.

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Bruton's tyrosine kinase (BTK) and matrix metalloproteinase-9 (MMP-9) regulate NLRP3 inflammasome-dependent cytokine and neutrophil extracellular trap responses in primary neutrophils.

J Allergy Clin Immunol

November 2024

Institute of Immunology, Department of Innate Immunity, University of Tübingen, Tübingen, Germany; iFIT-Cluster of Excellence (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies, " University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Partner Site Tübingen, Tübingen, Germany; CMFI-Cluster of Excellence (EXC 2124) "Controlling Microbes to Fight Infection, " University of Tübingen, Tübingen, Germany. Electronic address:

Article Synopsis
  • Inflammation is essential for protecting the body but can also damage it; neutrophils play a key role in this process by releasing proteins and forming structures called NETs.
  • The study investigated the role of Bruton's tyrosine kinase (BTK) in regulating the NLRP3 inflammasome in neutrophils, as this aspect had not been previously explored.
  • Findings revealed that when BTK was absent or inhibited, there was an increase in the inflammatory responses in neutrophils, suggesting that BTK negatively regulates NLRP3 activation, which could have implications for using BTK inhibitors in treatment.
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[Skin aging and dermatoporosis-the chronic skin fragility syndrome].

Dermatologie (Heidelb)

December 2024

Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland.

Skin aging is divided into intrinsic and extrinsic aging, encompassing pigmentary, vascular, connective tissue, and fat tissue aspects that contribute to this complex process. Aging is genetically determined but is influenced by environmental factors such as ultraviolet radiation, air pollution, and smoking. Skin aging has not only cosmetic but also functional implications, as the loss of the extracellular matrix, especially hyaluronate, impairs the mechanical functions of the skin.

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