Retinal structure and its relationship with premorbid, clinical, and cognitive variables in young Spanish patients with early course schizophrenia spectrum disorders.

Emerging evidence suggests that retinal structural alterations are present in schizophrenia spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and neurodegenerative processes. This cross-sectional study investigates retinal thickness and its clinical correlations in a sample of early-course SSD patients compared to healthy controls (HCs). One hundred-two eyes from 26 SSD cases and 25 age- and sex-matched HCs were included.

Contrasting genetic burden for bipolar disorder: Early onset versus late onset in an older adult bipolar disorder sample.

Older Adults with Bipolar Disorder (OABD) represent a heterogeneous group, including those with early and late onset of the disorder. Recent evidence shows both groups have distinct clinical, cognitive, and medical features, tied to different neurobiological profiles. This study explored the link between polygenic risk scores (PRS) for bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and major depressive disorder (PRS-MDD) with age of onset in OABD.

Mechanisms of alignment of lamellar-forming block copolymer under shear flow.

The potential applications of block copolymer thin films, utilising their self-assembly capabilities, are enhanced when achieving long-range ordering. In this study we explain the experimental alignment of lamellae under shear flow findings [S. Pujari , 2012, , 5258] and classify the alignment mechanisms based on shear rate and segregation, uncovering similarities to the systems subjected to electric fields, suggesting a common pathway of lamellae orientations.

A large-scale screening of hepatitis C among men who have sex with men in the community using saliva point-of-care testing.

Aim: To assess the feasibility and acceptability of massive hepatitis C virus (HCV) testing in point of care on the street using quick tests, determine the characteristics of the population included, and the prevalence of HCV infection in this population.

Methods: Cross-sectional community-based study including adult men who have sex with men (MSM) who attended the three most important LGTB+ events in Sitges (Catalonia, Spain) in 2022. Points of care were set up on tents on the street and attendees were offered voluntary anti-HCV antibody self-testing.

Hedonic Responses to Meal Ingestion in Patients With Functional Dyspepsia and Postprandial Symptoms.

Introduction: It is not clear whether patients with postprandial symptoms enjoy the meal.

Methods: Prospective trial in patients with postprandial distress syndrome and healthy controls, comparing their responses with stepwise ingestion of a comfort meal.

Results: Healthy individuals (N = 18) enjoyed the meal and experienced digestive well-being.

Silicon oxide microchips functionalized with fluorescent probes for quantitative real-time glutathione sensing in living cells.

Glutathione (GSH) plays a vital role in the regulation of intracellular functions which alterations in physiological glutathione levels are associated to various diseases. Molecular bioimaging is a sensitive method for GSH detection, but challenges persist in the development of fluorescent probes, mainly concerning long-term tracking of intracellular GSH concentration because of aggregation of molecular probes and their washout in cells. Engineered nanomaterials have shown great promise for increasing the disease diagnosis accuracy.

Worldwide comparison of carbon stocks and fluxes between native and non-native forests.

Climate change is one of the main challenges that human societies are currently facing. Given that forests represent major natural carbon sinks in terrestrial ecosystems, administrations worldwide are launching broad-scale programs to promote forests, including stands of non-native trees. Yet, non-native trees may have profound impacts on the functions and services of forest ecosystems, including the carbon cycle, as they may differ widely from native trees in structural and functional characteristics.

Long-Term Observations on the European Photopatch Test Baseline Series (EPTBS) in Real Clinical Practice: 11 Years of Results in a Spanish Cohort and Suggestions for an EPTBS Update.

Background: The European Photopatch Testing Baseline Series (EPTBS) was published in 2013. However, limited data exist regarding the real-world clinical application of the EPTBS.

Objectives: This study aims to describe the photopatch test experience with the EPTBS over 11 years at a tertiary hospital in Spain.

Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes.

Background: The global incidence of type 2 diabetes (T2D) is rapidly increasing, with retinopathy being its most common complication and a leading cause of preventable blindness. Although the precise mechanisms involved in the development of diabetic retinopathy (DR) are not fully understood, defective immunomodulation is a recognized key factor in its pathophysiology. Regulatory T cells (Treg) regulate inflammation and promote regeneration, and while they are known to have important anti-inflammatory and neuroprotective roles in other tissues, including central nervous system, their role in the diabetic retina remains largely unknown.

Is pancreatitis associated with meglumine antimoniate treatment for canine leishmaniosis? A multicentric prospective study.

Background: Meglumine antimoniate is used to treat canine leishmaniosis. In humans, it has been associated with pancreatitis. Although a few case reports have described acute pancreatitis secondary to antimonial treatment in dogs, some studies have concluded that pancreatitis is not an adverse effect of this medication.

Fishery and ecology-related knowledge about plants among fishing communities along Laguna Lake, Philippines.

Background: Ethnobotanical knowledge about plant roles in fisheries is crucial for sustainable resource management. Local ecological knowledge helps understand dynamics of the lake ecosystem. Fishers use plants based on availability and characteristics while adapting to the changes in the environment.

Merging and Clipping Nets for the Synthesis of Three- and Two-Merged Net Metal-Organic Frameworks.

Herein, we report how merging and clipping nets in metal-organic frameworks (MOFs) can be controlled in a single-crystal-to-single-crystal fashion using three different approaches─the merged net, clip-off chemistry, and linker reinstallation─to design and synthesize three- and two-merged net MOFs. Initially, we show the formation of three isoreticular three-merged net MOFs by linking a trimeric Sc cluster, Sc(μ-Ο)(-COO), with ditopic zigzag and tritopic linkers. The resulting MOFs exhibit three-merged edge-transitive nets─ + + ─for the first time.

Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023-2024: EPICOVIDEHA-EPIFLUEHA Report.

Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season.

Stabilizer Tensor Networks: Universal Quantum Simulator on a Basis of Stabilizer States.

Efficient simulation of quantum computers relies on understanding and exploiting the properties of quantum states. This is the case for methods such as tensor networks, based on entanglement, and the tableau formalism, which represents stabilizer states. In this Letter, we integrate these two approaches to present a generalization of the tableau formalism used for Clifford circuit simulation.

potentiation of tetracyclines in by RW01, a new cyclic peptide.

The pipeline for new drugs against multidrug-resistant remains limited, highlighting the urgent need for innovative treatments. New strategies, such as membrane-targeting molecules acting as adjuvants, aim to enhance antibiotic effectiveness and combat resistance. RW01, a cyclic peptide with low antimicrobial activity, was selected as an adjuvant to enhance drug efficacy through membrane permeabilization.

Undergraduate setup for measuring the Bell inequalities and performing quantum state tomography.

The growth of quantum technologies is attracting the interest of many students eager to learn concepts such as quantum entanglement or quantum superposition. However, the non-intuitive nature of these concepts poses a challenge to understanding them. Here, we present an entangled photon system which can perform a Bell test, i.

Urine analysis in monoclonal gammopathies at diagnosis: settling cut-off values.

Objectives: Laboratory testing has an extensive role in the diagnosis of monoclonal gammopathies. Since the last updates of the International Myeloma Working Group (IMWG) guidelines for the diagnosis of monoclonal gammopathies, debate has arisen as to whether urine analysis remains relevant for the diagnosis of these entities.

Methods: We carried out a retrospective study with data from 132 patients with a newly diagnosed serum M-protein.

The pan-cancer landscape of aldo-keto reductase1B10 reveals that its expression is diminished in gastric cancer.

Introduction: Aldo-keto reductase 1B10 (AKR1B10) is a multifunctional enzyme, which is important in cancer development and progression, but the landscape of AKR1B10 in pan-cancers and in tumor microenvironment is unclear.

Method: This study integrated the sequencing data of 33 cancer types, including gastric cancer, from TCGA project to explored the expression pattern and genetic and epigenetic alterations of AKR1B10. The association of AKR1B10 expression with clinical progression of cancers was evaluated by Kaplan-Meier analysis; the potential role of AKR1B10 in tumor microenvironment (TME) and immune-related gene expression were analyzed by PURITY, ESTIMATE, TIMER and CIBERSORT algorithms.

α-Synuclein Gene Hypomethylation in LRRK2 Parkinson's Disease Patients.

Background: α-Synuclein (SNCA) gene hypomethylation was reported in idiopathic Parkinson's disease (iPD). Based on a high clinical resemblance between iPD and leucine-rich repeat kinase 2 (LRRK2)-driven Parkinson's disease (L2PD), we investigated the epigenetic status of SNCA in an extensive LRRK2 clinical cohort from Spain.

Methods: We assessed the methylation levels of 23 CpG sites in the SNCA promoter region using peripheral blood DNA from L2PD patients (n = 151), LRRK2 nonmanifesting carriers (n = 55), iPD patients (n = 115), and healthy control subjects (n = 154) (total: N = 475).