1 results match your criteria: "Universitat de Valencia fCenter for Public Health Research-Valencia (CSISP-FISABIO)[Affiliation]"
Meta-analysis and systematic review of the effect of the donor and recipient CYP3A5 6986A>G genotype on tacrolimus dose requirements in liver transplantation.
Pharmacogenet Genomics
October 2013
aDepartment of Internal Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile bPharmacogenetic Unit, Drugs Clinical Area, Hospital Universitari i Politècnic La Fe e Instituto de Investigación Sanitaria La Fe. cHepatology Unit. Hospital Universitari i Politècnic La Fe dClinical Pharmacology Unit, Drugs Clinical Area, Hospital Universitari i Politècnic La Fe eDepartment of Pharmacology, Faculty of Medicine, Universitat de Valencia fCenter for Public Health Research-Valencia (CSISP-FISABIO), Health Services Research Network in Chronic Diseases (RESISSEC), Valencia, Spain.
Objective: A meta-analysis was carried out of published studies on the effect of the CYP3A5 6986A>G polymorphism in liver donors and transplant recipients on tacrolimus pharmacokinetics.
Methods: Cohort studies that evaluated the relationship between the CYP3A5 polymorphism in liver donors and transplant recipients and tacrolimus, trough blood concentration normalized for the daily dose (C) per kilogram body weight (D) (C/D, ng/ml/mg/kg/day) up to 1 year after transplantation, were included. Data were not restricted by patient age or the language or journal of publication.