A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.

Fasting metabolism and immunity are tightly linked; however, it is largely unknown how immune cells contribute to metabolic homeostasis during fasting in healthy subjects. Here, we combined cell-type-resolved genomics and computational approaches to map crosstalk between hepatocytes and liver macrophages during fasting. We identified the glucocorticoid receptor (GR) as a key driver of fasting-induced reprogramming of the macrophage secretome including fasting-suppressed cytokines and showed that lack of macrophage GR impaired induction of ketogenesis during fasting as well as endotoxemia.

[The new Parkinson's disease pain classification system (PD-PCS)].

Background: Chronic pain is a common non-motor symptom in patients with Parkinson's disease (PD).

Aim: To facilitate the diagnosis of pain in PD, we developed a new classification system the Parkinson's disease pain classification system (PD-PCS) and translated the corresponding validated questionnaire into German.

Methods: A causal relationship of the respective pain syndrome with PD can be determined by four questions before assigning it hierarchically into one of three pain categories (neuropathic, nociceptive and nociplastic).

Induction chemoimmunotherapy followed by CD8+ immune cell-based patient selection for chemotherapy-free radioimmunotherapy in locally advanced head and neck cancer.

Purpose: The first aim of the trial is to study feasibility of combined programmed death protein ligand 1/cytotoxic T-lymphocyte-associated protein 4 inhibition concomitant to radiotherapy. In addition, efficacy of the entire treatment scheme consisting of induction chemoimmunotherapy followed by chemotherapy-free radioimmunotherapy (RIT) after intratumoral CD8 +immune cell-based patient selection will be analyzed.

Methods: Patients with stage III-IVB head and neck squamous cell carcinoma were eligible for this multicenter phase II trial.

Improved team communication in endoscopic procedures by digital enhanced telecommunication during the COVID-19 pandemic.

Unbiased communication is crucial for excellent teamwork in high-quality endoscopy. Personal protective equipment (PPE) (FFP-masks and face-shields) worn by endoscopists that are ubiquitous in the current COVID-19 pandemic strikingly impair communication. Digital enhancement approaches to maintain team communication, especially during complex endoscopic procedures, are urgently warranted.

Utility of the Repeat and Point Test for Subtyping Patients With Primary Progressive Aphasia.

Background: Primary progressive aphasia (PPA) may present with three distinct clinical sybtypes: semantic variant PPA (svPPA), nonfluent/agrammatic variant PPA (nfvPPA), and logopenic variant PPA (lvPPA).

Objective: The aim was to examine the utility of the German version of the Repeat and Point (R&P) Test for subtyping patients with PPA.

Method: During the R&P Test, the examiner reads out aloud a noun and the participants are asked to repeat the word and subsequently point to the corresponding picture.

Chlorophyll- and anthocyanin-rich cell organelles affect light scattering in apple skin.

Apple skin contains several groups of strongly absorbing cell organelles with pigments that change dynamically in type and concentration during fruit maturation. Chlorophylls and carotenoids, both primarily involved in photosynthesis, are found in the grana of chloroplasts, while anthocyanin vacuolar inclusions (AVIs) accumulate for light protection in red-skinned cultivars. A Mie model describing light scattering by absorbing spherical particles in a non-absorbing medium allowed to theoretically investigate the explicit influence of grana and AVIs on the effective scattering coefficient [Formula: see text] and the absorption coefficient [Formula: see text].

Quantum computational advantage via high-dimensional Gaussian boson sampling.

Photonics is a promising platform for demonstrating a quantum computational advantage (QCA) by outperforming the most powerful classical supercomputers on a well-defined computational task. Despite this promise, existing proposals and demonstrations face challenges. Experimentally, current implementations of Gaussian boson sampling (GBS) lack programmability or have prohibitive loss rates.

The Association between Treatment Modality, Lipid Profile, Metabolic Control in Children with Type 1 Diabetes and Celiac Disease-Data from the International Sweet Registry.

Background And Aims: A higher frequency of dyslipidemia is reported in children with type 1 diabetes (T1D) and celiac disease (CD). Recently, continuous subcutaneous insulin infusion (CSII) has been associated with better lipid profiles in patients with T1D. The aim of this study was to investigate the association between treatment modality and lipid profile, metabolic control, and body mass index (BMI)-SDS in children with both T1D and CD.

[Case Report on the Treatment of Inner Restlessness with Biofeedback and Behavior Therapy].

Background: Inner restlessness is a frequently mentioned symptom in psychiatric-psychotherapeutic clinical practice, from which patients with various mental illnesses suffer.

Method: A patient with major depression was treated with a total of eight biofeedback sessions with the physiological parameter heart rate variability and three behavioral therapy sessions. Questionnaires were used to assess the symptom of inner restlessness and a possible success of the therapy.

Formation mechanism of Ruddlesden-Popper faults in compressive-strained ABO perovskite superlattices.

Ruddlesden-Popper (RP) faults have emerged as a promising candidate for defect engineering in epitaxial ABO perovskites. Functionalities could be fine-tuned by incorporating RP faults into ABO thin films and superlattices. However, due to the lattice expansion at AO-AO interfaces, it is generally believed that RP faults are only energetically favorable under tensile strain.

Is there evidence behind pre- or perioperative cognitive training in gynaecological patients on the prevention of perioperative cognitive dysfunction? A review.

Purpose: Perioperative cognitive dysfunction can be observed in all age groups of patients. Sometimes, this is more stressful to the patient than the actual surgical wound. Enhanced recovery after surgery pathways screen for patients at risk and lead to early post-surgical intervention.

Second sound in the crossover from the Bose-Einstein condensate to the Bardeen-Cooper-Schrieffer superfluid.

Second sound is an entropy wave which propagates in the superfluid component of a quantum liquid. Because it is an entropy wave, it probes the thermodynamic properties of the quantum liquid. Here, we study second sound propagation for a large range of interaction strengths within the crossover between a Bose-Einstein condensate (BEC) and the Bardeen-Cooper-Schrieffer (BCS) superfluid, extending previous work at unitarity.

[Peer Support: Utilization and Benefit in Severe Mental Illness - Results from an Observational, Cross-Sectional Study].

Objective: Peer support is playing an increasing role in the treatment of severely mentally ill people. International findings are available on its effectiveness. However, little is known about knowledge, use and benefit assessment in Germany.

Performance of intermittently scanned continuous glucose monitoring systems in people with type 1 diabetes: A pooled analysis.

Aims: To conduct a pooled analysis to assess the performance of intermittently scanned continuous glucose monitoring (isCGM) in association with the rate of change in sensor glucose in a cohort of children, adolescents, and adults with type 1 diabetes.

Material And Methods: In this pooled analysis, isCGM system accuracy was assessed depending on the rate of change in sensor glucose. Clinical studies that have been investigating isCGM accuracy against blood glucose, accompanied with collection time points were included in this analysis.

[Fatherhood and Depression: Dealing with Depression in the Family from the Fathers' Perspective - A Qualitative Study].

Objective: Investigation of the experiences of depressed fathers in dealing with their depressive disorder in the family.

Methods: 17 semi-structured narrative interviews were conducted and analyzed following a Grounded Theory Approach.

Results: Fathers describe individual coping strategies in dealing with their depressive disorder that aim at independently coping from their family (self-management, [non])disclosure of the disorder).

Liquid Phase Exfoliation of Rubrene Single Crystals into Nanorods and Nanobelts.

Liquid phase exfoliation (LPE) is a popular method to create dispersions of two-dimensional nanosheets from layered inorganic van der Waals crystals. Here, it is applied to orthorhombic and triclinic single crystals of the organic semiconductor rubrene with only noncovalent interactions (mainly π-π) between the molecules. Distinct nanorods and nanobelts of rubrene are formed, stabilized against aggregation in aqueous sodium cholate solution, and isolated by liquid cascade centrifugation.

[Predictors of the Use of Different Occupational Rehabilitation Measures: A Comparison of Integration Measures, Partial Qualifications and Full Training].

Purpose: Occupational rehabilitation is an essential part of supporting return to work by the statutory pension insurance institutes. It is useful if health-related restrictions threaten the ability to work. There are various forms of occupational rehabilitation which differ considerably in terms of content, structure, duration, intensity of care and costs.

SU(2) hadrons on a quantum computer via a variational approach.

Quantum computers have the potential to create important new opportunities for ongoing essential research on gauge theories. They can provide simulations that are unattainable on classical computers such as sign-problem afflicted models or time evolutions. In this work, we variationally prepare the low-lying eigenstates of a non-Abelian gauge theory with dynamically coupled matter on a quantum computer.

[Disease-modifying treatment approaches in Huntington disease : Past and future].

Huntington disease (HD) is the most frequent monogenetic neurodegenerative disease and can be unequivocally diagnosed even in the preclinical stage, at least in all individuals in whom the CAG expansion mutation in the huntingtin gene (HTT) is in the range of full penetrance. Therefore, important preconditions for an intervention early in the disease process are met, rendering modification of the course of the disease in a clinically meaningful way possible. In this respect, HD can be viewed as a model disorder for exploring neuroprotective treatment approaches.

Correction: AGO Recommendations for the Surgical Therapy of the Axilla After Neoadjuvant Chemotherapy: 2021 Update.

[This corrects the article DOI: 10.1055/a-1499-8431.].

Convergence Rates for the Quantum Central Limit Theorem.

Various quantum analogues of the central limit theorem, which is one of the cornerstones of probability theory, are known in the literature. One such analogue, due to Cushen and Hudson, is of particular relevance for quantum optics. It implies that the state in any single output arm of an -splitter, which is fed with copies of a centred state with finite second moments, converges to the Gaussian state with the same first and second moments as .

DYW domain structures imply an unusual regulation principle in plant organellar RNA editing catalysis.

RNA editosomes selectively deaminate cytidines to uridines in plant organellar transcripts-mostly to restore protein functionality and consequently facilitate mitochondrial and chloroplast function. The RNA editosomal pentatricopeptide repeat proteins serve target RNA recognition, whereas the intensively studied DYW domain elicits catalysis. Here we present structures and functional data of a DYW domain in an inactive ground state and activated.