Evaluating environmental benefits of low-cost biogas digesters in small-scale farms in Colombia: A life cycle assessment.

The aim of this study was to assess the environmental benefits of implementing low-cost digesters in small-scale farms in Colombia by using the LCA methodology. Four scenarios were taken into account considering two small-scale farms located in different areas: two (previous) scenarios where manure was stored in a manure pit and liquefied petroleum gas (LPG) was used for cooking; and two (current) scenarios where manure is treated in low-cost digesters, the digestate replaces the synthetic fertiliser and the biogas is used for cooking replacing the LPG. Results showed that digesters implementation considerably reduced (by up to 80%) potential environmental impacts associated with manure handling, fuel and fertiliser use in the small-scale Colombian farms.

Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell.

Cells rely on an interplay of subcellular elements for motility and migration. Certain regions of motile cells, such as the lamellipodium, are made of a complex mixture of actin monomers and filaments, which polymerize at the front of the cell, close to the cell membrane, and depolymerize at the rear. The dynamic actin turnover induces the so-called intracellular retrograde flow, and it is a fundamental process for cell motility.

Considerations about the Determination of the Depolarization Calibration Profile of a Two-Telescope Lidar and Its Implications for Volume Depolarization Ratio Retrieval.

We propose a new method for calculating the volume depolarization ratio of light backscattered by the atmosphere and a lidar system that employs an auxiliary telescope to detect the depolarized component. It takes into account the possible error in the positioning of the polarizer used in the auxiliary telescope. The theory of operation is presented and then applied to a few cases for which the actual position of the polarizer is estimated, and the improvement of the volume depolarization ratio in the molecular region is quantified.

An Architecture Providing Depolarization Ratio Capability for a Multi-Wavelength Raman Lidar: Implementation and First Measurements.

A new architecture for the measurement of depolarization produced by atmospheric aerosols with a Raman lidar is presented. The system uses two different telescopes: one for depolarization measurements and another for total-power measurements. The system architecture and principle of operation are described.

Inspiratory muscle activation increases with COPD severity as confirmed by non-invasive mechanomyographic analysis.

There is a lack of instruments for assessing respiratory muscle activation during the breathing cycle in clinical conditions. The aim of the present study was to evaluate the usefulness of the respiratory muscle mechanomyogram (MMG) for non-invasively assessing the mechanical activation of the inspiratory muscles of the lower chest wall in both patients with chronic obstructive pulmonary disease (COPD) and healthy subjects, and to investigate the relationship between inspiratory muscle activation and pulmonary function parameters. Both inspiratory mouth pressure and respiratory muscle MMG were simultaneously recorded under two different respiratory conditions, quiet breathing and incremental ventilatory effort, in 13 COPD patients and 7 healthy subjects.

MERITXELL: The Multifrequency Experimental Radiometer with Interference Tracking for Experiments over Land and Littoral-Instrument Description, Calibration and Performance.

MERITXELL is a ground-based multisensor instrument that includes a multiband dual-polarization radiometer, a GNSS reflectometer, and several optical sensors. Its main goals are twofold: to test data fusion techniques, and to develop Radio-Frequency Interference (RFI) detection, localization and mitigation techniques. The former is necessary to retrieve complementary data useful to develop geophysical models with improved accuracy, whereas the latter aims at solving one of the most important problems of microwave radiometry.

A Real-Time Method for Decoding the Neural Drive to Muscles Using Single-Channel Intra-Muscular EMG Recordings.

The neural command from motor neurons to muscles - sometimes referred to as the neural drive to muscle - can be identified by decomposition of electromyographic (EMG) signals. This approach can be used for inferring the voluntary commands in neural interfaces in patients with limb amputations. This paper proposes for the first time an innovative method for fully automatic and real-time intramuscular EMG (iEMG) decomposition.

Estimating bradykinesia severity in Parkinson's disease by analysing gait through a waist-worn sensor.

Bradykinesia is a cardinal symptom of Parkinson's disease (PD) and describes the slowness of movement revealed in patients. Current PD therapies are based on dopamine replacement, and given that bradykinesia is the symptom that best correlates with the dopaminergic deficiency, the knowledge of its fluctuations may be useful in the diagnosis, treatment and better understanding of the disease progression. This paper evaluates a machine learning method that analyses the signals provided by a triaxial accelerometer placed on the waist of PD patients in order to automatically assess bradykinetic gait unobtrusively.

An experimental study of ultrasonic vibration and the penetration of granular material.

This work investigates the potential use of direct ultrasonic vibration as an aid to penetration of granular material. Compared with non-ultrasonic penetration, required forces have been observed to reduce by an order of magnitude. Similarly, total consumed power can be reduced by up to 27%, depending on the substrate and ultrasonic amplitude used.

Home detection of freezing of gait using support vector machines through a single waist-worn triaxial accelerometer.

Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, which may not accurately map the severity of this symptom. The use of a non-invasive system to monitor the activities of daily living (ADL) and the PD symptoms experienced by patients throughout the day could provide a more accurate and objective evaluation of FoG in order to better understand the evolution of the disease and allow for a more informed decision-making process in making adjustments to the patient's treatment plan.

SNR and Standard Deviation of cGNSS-R and iGNSS-R Scatterometric Measurements.

This work addresses the accuracy of the Global Navigation Satellite Systems (GNSS)-Reflectometry (GNSS-R) scatterometric measurements considering the presence of both coherent and incoherent scattered components, for both conventional GNSS-R (cGNSS-R) and interferometric GNSS-R (iGNSS-R) techniques. The coherent component is present for some type of surfaces, and it has been neglected until now because it vanishes for the sea surface scattering case. Taking into account the presence of both scattering components, the estimated Signal-to-Noise Ratio (SNR) for both techniques is computed based on the detectability criterion, as it is done in conventional GNSS applications.

Detection of Multiple Innervation Zones from Multi-Channel Surface EMG Recordings with Low Signal-to-Noise Ratio Using Graph-Cut Segmentation.

Knowledge of the location of muscle Innervation Zones (IZs) is important in many applications, e.g. for minimizing the quantity of injected botulinum toxin for the treatment of spasticity or for deciding on the type of episiotomy during child delivery.

Critical review: Injectability of calcium phosphate pastes and cements.

Unlabelled: Calcium phosphate cements (CPC) have seen clinical success in many dental and orthopaedic applications in recent years. The properties of CPC essential for clinical success are reviewed in this article, which includes properties of the set cement (e.g.

Reuse of Textile Dyeing Effluents Treated with Coupled Nanofiltration and Electrochemical Processes.

The reactive dye Cibacron Yellow S-3R was selected to evaluate the feasibility of combining nanofiltration membranes with electrochemical processes to treat textile wastewater. Synthetic dyeing effluents were treated by means of two nanofiltration membranes, Hydracore10 and Hydracore50. Up to 98% of dye removal was achieved.

A methodology to quantify the differences between alternative methods of heart rate variability measurement.

This work proposes a systematic procedure to report the differences between heart rate variability time series obtained from alternative measurements reporting the spread and mean of the differences as well as the agreement between measuring procedures and quantifying how stationary, random and normal the differences between alternative measurements are. A description of the complete automatic procedure to obtain a differences time series (DTS) from two alternative methods, a proposal of a battery of statistical tests, and a set of statistical indicators to better describe the differences in RR interval estimation are also provided. Results show that the spread and agreement depend on the choice of alternative measurements and that the DTS cannot be considered generally as a white or as a normally distributed process.

Myopia Control with a Novel Peripheral Gradient Soft Lens and Orthokeratology: A 2-Year Clinical Trial.

Objective: To evaluate the degree of axial elongation with soft radial refractive gradient (SRRG) contact lenses, orthokeratology (OK), and single vision (SV) spectacle lenses (control) during a period of 1 year before treatment and 2 years after treatment.

Methods: This was a prospective, longitudinal, nonrandomized study. The study groups consisted of 30, 29, and 41 children, respectively.

Processing Diabetes Mellitus Composite Events in MAGPIE.

The focus of this research is in the definition of programmable expert Personal Health Systems (PHS) to monitor patients affected by chronic diseases using agent oriented programming and mobile computing to represent the interactions happening amongst the components of the system. The paper also discusses issues of knowledge representation within the medical domain when dealing with temporal patterns concerning the physiological values of the patient. In the presented agent based PHS the doctors can personalize for each patient monitoring rules that can be defined in a graphical way.

Monitoring sleep depth: analysis of bispectral index (BIS) based on polysomnographic recordings and sleep deprivation.

The assessment and management of sleep are increasingly recommended in the clinical practice. Polysomnography (PSG) is considered the gold standard test to monitor sleep objectively, but some practical and technical constraints exist due to environmental and patient considerations. Bispectral index (BIS) monitoring is commonly used in clinical practice for guiding anesthetic administration and provides an index based on relationships between EEG components.

Multiple characterization study on porosity and pore structure of calcium phosphate cements.

Unlabelled: Characterization of the intricate pore structure of calcium phosphate cements is a key step to successfully link the structural properties of these synthetic bone grafts with their most relevant properties, such as in vitro or in vivo behaviour, drug loading and release properties, or degradation over time. This is a challenging task due to the wide range of pore sizes in calcium phosphate cements, compared to most other ceramic biomaterials. This work provides a critical assessment of three different techniques based on different physical phenomena, namely mercury intrusion porosimetry (MIP), Nitrogen sorption, and thermoporometry (TPM) for the detailed characterization of four calcium phosphate cements with different textural properties in terms of total porosity, pore size distribution (PSD), and pore entrance size distribution (PESD).

Different Organization of Type I Collagen Immobilized on Silanized and Nonsilanized Titanium Surfaces Affects Fibroblast Adhesion and Fibronectin Secretion.

Silanization has emerged in recent years as a way to obtain a stronger and more stable attachment of biomolecules to metallic substrates. However, its impact on protein conformation, a key aspect that influences cell response, has hardly been studied. In this work, we analyzed by atomic force microscopy (AFM) the distribution and conformation of type I collagen on plasma-treated surfaces before and after silanization.

Relevance of Toxicity Assessment in Wastewater Treatments: Case Study-Four Fenton Processes Applied to the Mineralization of C.I. Acid Red 14.

Fenton and Fenton-like processes, both in homogeneous and heterogeneous phases, have been applied to an aqueous solution containing the dye AR 14 in order to study the mineralization and toxicity of the solutions generated after color elimination. The mineralization of AR 14 occurred slower than the decolorization. The Microtox analysis of the treated solutions showed low toxicity intrinsic to the chemicals used in the process rather than the degradation products obtained after the treatment of the dye solution.

Evaluation of multiple comparison correction procedures in drug assessment studies using LORETA maps.

The identification of the brain regions involved in the neuropharmacological action is a potential procedure for drug development. These regions are commonly determined by the voxels showing significant statistical differences after comparing placebo-induced effects with drug-elicited effects. LORETA is an electroencephalography (EEG) source imaging technique frequently used to identify brain structures affected by the drug.

Photo-Electrochemical Treatment of Reactive Dyes in Wastewater and Reuse of the Effluent: Method Optimization.

In this work, the efficiency of a photo-electrochemical method to remove color in textile dyeing effluents is discussed. The decolorization of a synthetic effluent containing a bi-functional reactive dye was carried out by applying an electrochemical treatment at different intensities (2 A, 5 A and 10 A), followed by ultraviolet irradiation. The combination of both treatments was optimized.

SVM-based feature selection to optimize sensitivity-specificity balance applied to weaning.

Classification algorithms with unbalanced datasets tend to produce high predictive accuracy over the majority class, but poor predictive accuracy over the minority class. This problem is very common in biomedical data mining. This paper introduces a Support Vector Machine (SVM)-based optimized feature selection method, to select the most relevant features and maintain an accurate and well-balanced sensitivity-specificity result between unbalanced groups.