Comparing quantile regression spline analyses and supervised machine learning for environmental quality assessment at coastal marine aquaculture installations.

Organic enrichment associated with marine finfish aquaculture is a local stressor of marine coastal ecosystems. To maintain ecosystem services, the implementation of biomonitoring programs focusing on benthic diversity is required. Traditionally, impact-indices are determined by extracting and identifying benthic macroinvertebrates from samples.

Nucleotide Limitation Results in Impaired Photosynthesis, Reduced Growth and Seed Yield Together with Massively Altered Gene Expression.

Nucleotide limitation and imbalance is a well-described phenomenon in animal research but understudied in the plant field. A peculiarity of pyrimidine de novo synthesis in plants is the complex subcellular organization. Here, we studied two organellar localized enzymes in the pathway, with chloroplast aspartate transcarbamoylase (ATC) and mitochondrial dihydroorotate dehydrogenase (DHODH).

Investigation of the stress reduction and temperature increase due to ultrasonic vibrations with different amplitudes during compression tests of steels with varying specimen sizes.

High-frequency vibrations in the ultrasonic range influence the plasticity of metals during metal forming: there is stress and force reduction during ultrasonic treatment compared to metal forming without ultrasound. Different reasons for this behavior are discussed: a combination of stress superposition, energy absorption in dislocations, temperature increase, and frictional changes. This investigation shows the influence of partially superimposed ultrasonic vibrations with amplitudes in the range of ∼ 1.

Identification of genomic biomarkers and their pathway crosstalks for deciphering mechanistic links in glioblastoma.

Glioblastoma is a grade IV pernicious neoplasm occurring in the supratentorial region of brain. As its causes are largely unknown, it is essential to understand its dynamics at the molecular level. This necessitates the identification of better diagnostic and prognostic molecular candidates.

Machine Learning and Explainable Artificial Intelligence Using Counterfactual Explanations for Evaluating Posture Parameters.

Postural deficits such as hyperlordosis (hollow back) or hyperkyphosis (hunchback) are relevant health issues. Diagnoses depend on the experience of the examiner and are, therefore, often subjective and prone to errors. Machine learning (ML) methods in combination with explainable artificial intelligence (XAI) tools have proven useful for providing an objective, data-based orientation.

Corrigendum: Position statement and updated international guideline for safe and effective whole-body electromyostimulation training-the need for common sense in WB-EMS application.

[This corrects the article DOI: 10.3389/fphys.2023.

Interrelated dataset of rebound numbers, ultrasonic pulse velocities and compressive strengths of drilled concrete cores from an existing structure and new fabricated concrete cubes.

Two test series were examined using nondestructive measuring methods by six independent laboratories before determining their compressive strength. The nondestructive test methods used were the rebound hammer and ultrasonic pulse velocity measurement. Two types of geometries were investigated: drilled cores and cubes.

Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis.

This study aimed to elucidate the gastro-protective effect of fucoidan against ethanol-induced gastric ulcer mediated via NLRP3-induced pyroptosis as an underlying mechanism, not yet assessed in prior research. Forty-eight male Albino mice were divided into six groups: Group I (normal control), group II (Ulcer/ethanol control), group III (Omeprazole + ethanol), group IV (fucoidan 25 mg + ethanol), group V (fucoidan 50 mg + ethanol) and group VI (fucoidan only). Fucoidan was administered orally for seven consecutive days followed by ulcer induction by a single oral dose of ethanol.

Characterization of brewer's spent grain extracts by tandem mass spectrometry and HPLC-DAD: Ferulic acid dehydrodimers, phenolamides, and oxylipins.

Brewer's spent grain (BSG) is a major by-product of the brewing industry which is generated in high amounts. In recent years, sustainable food production has become more and more important. BSG mainly used as cattle feed has gained high interest due to not only its valuable ingredients such as fiber and proteins but also secondary metabolites remaining in BSG after the brewing process and known for many biological effects.

Interfacial engineering of ferromagnetism in wafer-scale van der Waals FeGeTe far above room temperature.

Despite recent advances in exfoliated vdW ferromagnets, the widespread application of 2D magnetism requires a Curie temperature (T) above room temperature as well as a stable and controllable magnetic anisotropy. Here we demonstrate a large-scale iron-based vdW material FeGeTe with the T reaching ~530 K. We confirmed the high-temperature ferromagnetism by multiple characterizations.

Open system control of dynamical transitions under the generalized Kruskal-Neishtadt-Henrard theorem.

Useful dynamical processes often begin through barrier-crossing dynamical transitions; engineering system dynamics in order to make such transitions reliable is therefore an important task for biological or artificial microscopic machinery. Here, we first show by example that adding even a small amount of back-reaction to a control parameter, so that it responds to the system's evolution, can significantly increase the fraction of trajectories that cross a separatrix. We then explain how a post-adiabatic theorem due to Neishtadt can quantitatively describe this kind of enhancement without having to solve the equations of motion, allowing systematic understanding and design of a class of self-controlling dynamical systems.

Position statement and updated international guideline for safe and effective whole-body electromyostimulation training-the need for common sense in WB-EMS application.

Whole-Body Electromyostimulation (WB-EMS) is a training technology that enables simultaneous stimulation of all the main muscle groups with a specific impulse intensity for each electrode. The corresponding time-efficiency and joint-friendliness of WB-EMS may be particularly attractive for people unable or unmotivated to conduct (intense) conventional training protocols. However, due to the enormous metabolic and musculoskeletal impact of WB-EMS, particular attention must be paid to the application of this technology.

How to foster STEM learning during Covid-19 remote schooling: Combining virtual and video experiments.

Understanding scientific concepts is a fundamental aim of science education. Conceptual understanding can be fostered through inquiry learning with experiments. However, during the Covid-19 pandemic school closures hands-on experiments could hardly be realized.

Reference Values for Sagittal Clinical Posture Assessment in People Aged 10 to 69 Years.

Poor posture is a well-known problem in all age groups and can lead to back pain, which in turn can result in high socio-economic costs. Regular assessment of posture can therefore help to identify postural deficits at an early stage in order to take preventive measures and can therefore be an important tool for promoting public health. We measured the posture of 1127 symptom-free subjects aged 10 to 69 years using stereophotogrammetry and determined the sagittal posture parameters (FC), (FL), and kyphosis index (KI) as well as the values standardized to the trunk height (FC%, FL%, KI%).

Periodic Mesoporous Organosilica Nanomaterials with Unconventional Structures and Properties.

Periodic mesoporous organosilicas (PMOs) are high surface area organic-inorganic hybrid nanomaterials that have found broad applications in various fields of research such as in (bio)chemistry or material science. By choosing suitable organic groups in the framework of these materials, their surface properties such as polarity, optical/electrical characteristics and adsorption capacity can be tuned. This critical review provides an overview of the current state of the art in the developments and applications of some PMO nanomaterials in diverse fields of research.

Geographic characteristics and environmental variables determine the diversities and assembly of the algal communities in interconnected river-lake system.

Algal blooms in lakes are a major hazard worldwide. Although various geographical and environmental patterns affect algal communities during river-lake transit, a thorough understanding of what patterns shape the algal communities is still rarely researched, particularly in complex interconnected river-lake systems. In this study, focusing on the most typical interconnected river-lake system in China, the Dongting Lake, we collected paired water and sediment samples in summer, when algal biomass and growth rate are at high levels.

Effect of Cholesterol on the Structure and Composition of Glyco-DIBMA Lipid Particles.

Different amphiphilic co-polymers have been introduced to produce polymer-lipid particles with nanodisc structure composed of an inner lipid bilayer and polymer chains self-assembled as an outer belt. These particles can be used to stabilize membrane proteins in solution and enable their characterization by means of biophysical methods, including small-angle X-ray scattering (SAXS). Some of these co-polymers have also been used to directly extract membrane proteins together with their associated lipids from native membranes.

In Vivo Monitoring of Acute and Intermittent Fatigue in Sport Climbing Using Near-Infrared Spectroscopy Wearable Biosensors.

The objectification of acute fatigue (during isometric muscle contraction) and cumulative fatigue (due to multiple intermittent isometric muscle contractions) plays an important role in sport climbing. The data of 42 participants were used in the study. Climbing performance was operationalized using maximal climbing-specific holding time (CSHT) by performing dead hangs.

Fucoidan in Pharmaceutical Formulations: A Comprehensive Review for Smart Drug Delivery Systems.

Fucoidan is a heterogeneous group of polysaccharides isolated from marine organisms, including brown algae and marine invertebrates. The physicochemical characteristics and potential bioactivities of fucoidan have attracted substantial interest in pharmaceutical industries in the past few decades. These polysaccharides are characterized by possessing sulfate ester groups that impart negatively charged surfaces, low/high molecular weight, and water solubility.

[Relational dealing with crisis of youth welfare professionals in casework regarding the effects of the Covid 19 pandemic].

There is still little empirical knowledge about the impact of the Covid 19 pandemic on the casework of youth welfare offices. However, qualitative studies provide a number of indications on the importance of teamwork, on explicit and implicit ways of acting as well as on decision-making practices (sense-making) of professionals in child protection. These aspects were largely limited by the lockdowns and the pandemic-related protective measures.

Quantifying the effect of delaying the second COVID-19 vaccine dose in England: a mathematical modelling study.

Background: The UK was the first country to start national COVID-19 vaccination programmes, initially administering doses 3 weeks apart. However, early evidence of high vaccine effectiveness after the first dose and the emergence of the SARS-CoV-2 alpha variant prompted the UK to extend the interval between doses to 12 weeks. In this study, we aimed to quantify the effect of delaying the second vaccine dose in England.

Ultrafast spectroscopy of Ru polypyridine complexes in the gas phase and the liquid phase: [Ru(2,2'-bipyridine)(nicotinamide)].

[Ru(bipyridine)(nicotinamide)] (1) and its monoaqua-complex [Ru(bipyridine)(nicotinamide)(HO)] (2) were spectroscopically studied for the first time in the gas phase by static and time resolved UV photodissociation spectroscopy, observing nicotinamide and HO ligand dissociation for 1 and 2, respectively. Both processes and their ultrafast dynamics were investigated in parallel by transient absorption spectroscopy in aqueous solution. The latter data were newly acquired for the long-wavelength MLCT band excitation of 1 and provide novel ultrafast ligand dissociation results for 2, confirming the gas phase results, , exclusive HO cleavage over nicotinamide loss.

Stability analysis of a multiscale model of cell cycle dynamics coupled with quiescent and proliferating cell populations.

In this paper, we perform a mathematical analysis of our proposed nonlinear, multiscale mathematical model of physiologically structured quiescent and proliferating cell populations at the macroscale and cell-cycle proteins at the microscale. Cell cycle dynamics (microscale) are driven by growth factors derived from the total cell population of quiescent and proliferating cells. Cell-cycle protein concentrations, on the other hand, determine the rates of transition between the two subpopulations.

Characterization and Cytotoxic Activity of Microwave-Assisted Extracted Crude Fucoidans from Different Brown Seaweeds.

Microwave-assisted extraction (MAE) is recognized as a green method for extraction of natural products. The current research aimed to explore the MAE for fucoidans extraction from different brown seaweeds, including , , and . Following several solvent-extraction pre-treatment steps and MAE optimization, the algal biomasses were extracted in a ratio of 1:25 in 0.

Polyphenol-Rich Beverage Consumption Affecting Parameters of the Lipid Metabolism in Healthy Subjects.

Polyphenols are a diverse and widely distributed class of secondary metabolites, which possess numerous beneficial properties including a modulation of glucose and lipid metabolism. This placebo-controlled human intervention study was performed to explore effects of polyphenol-rich beverage (PRB) uptake on lipid metabolism, as well as DNA integrity. In this case, 36 healthy men were randomly divided to consume either 750 mL of a PRB (containing 51% chokeberry, cranberry, and pomegranate) or a placebo drink daily for eight weeks.