Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells.

Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed.

Use of fluorescence spectroscopy to study polymeric materials with porous structure based on imprinting by self-assembled fibrillar networks.

Different polymeric materials have been prepared from the organogels formed by a polymerizable methacrylic mixture (methyl methacrylate/ethylene glycol dimethacrylate, 1:1, w/w) and the macrocyclic pseudopeptide 1. The use of (2,4,6-trimethylbenzoyl)diphenylphosphine oxide as a very efficient radical initiator allows polymeric materials in which the structure of the fibrils formed by self-assembly of the organogelator 1 is truly preserved to be obtained. Removal of the pseudopeptidic molecule provides materials with a porous structure reflecting that of the original self-assembled fibrils.

Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells.

Spectroscopic analysis of the fluorescent probe 1,2-diaminoanthraquinone () provides information about the mechanism of nitric oxide imaging in living cells. Fluorescent aggregates of a reaction product of are thought to be responsible for the images obtained with confocal fluorescence microscopy.

A turn-on fluorescent indicator for citrate with micromolar sensitivity.

A turn-on fluorescent indicator for citric acid (citrate) has been developed, displaying high emission enhancement (+1500%) and low interference by other carboxylates. The sensor is based on the non-emissive copper(II) complex of a fluorescent amino amide, which, upon addition of citrate decomplexates to yield the emissive ligand. The detection limit estimated for this new chemosensing system is about 0.

Polymer supported ionic liquid phases (SILPs) versus ionic liquids (ILs): how much do they look alike.

The fluorescence of pyrene has been used for the first time to measure the static dielectric constant of a series of supported ionic liquids phases (SILPs) based on polymeric polystyrene networks.