Multiple Lurias. Reconstructing Alexander Romanovich's Life-Writing.

While widely considered Alexander Luria's (1902-1977) autobiography, The Making of Mind. A Personal Account of Soviet Psychology, published posthumously in 1979, is not a true autobiography but rather an autobiography with heterobiographic elements. However, the largely overlooked Spanish book, Mirando hacia atrás.

[Unmet health care needs of younger and older people with intellectual, mental and multiple disabilities: A pilot study in a facility in the Ruhr area].

Introduction: Unmet health care needs are seen as a key indicator of equity in access to health care. With younger people, they can lead to poorer health outcomes in adulthood, and in older people they can be associated with an increased risk of mortality. The presence of a disability is considered a risk factor for unmet needs.

Manifestation of Rouse and Entanglement Dynamics in Non-Cross-Linked and Cross-Linked Polymers Studied by Field-Cycling and Multiple Quantum NMR.

Rubbers prepared from technical poly(butadiene) and natural poly(isoprene) are studied by field-cycling (FC) H NMR relaxometry to elucidate the changes of the relaxation spectrum. Starting with the non-cross-linked polymer successively cross-links are introduced via sulfur or peroxide vulcanization. Applying an advanced home-built relaxometer allows one to probe entanglement dynamics in addition to Rouse dynamics.

A protein interaction map of the myosin Myo2 reveals a role of Alo1 in mitochondrial inheritance in yeast.

Budding yeast cells multiply by asymmetric cell division. During this process, the cell organelles are transported by myosin motors along the actin cytoskeleton into the growing bud, while at the same time some organelles must be retained in the mother cell. The ordered partitioning of organelles depends on highly regulated binding of motor proteins to cargo membranes.

The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precursor Analogues.

Ketoreductases (KRs) are domains in the reductive loops of type I polyketide synthases (PKSs) and are responsible for the majority of stereocenters in reduced polyketides. Although the highly stereoselective reduction of ACP-bound β-ketothioester intermediates by KRs is crucial for the overall functioning of PKSs, the substrate-dependent stereoselectivity of KRs is a factor that is not yet fully understood, especially for KR domains in late PKS modules that act on biosynthetic precursors with complex polyketidic moieties. We present studies on the three KR domains FosKR7, PlmKR6, and EryKR6 from the biosynthetic pathways of fostriecin, phoslactomycin, and erythromycin by in vitro assays using close surrogates of the octaketidic FosKR7 biosynthetic precursor, complex derivatives and a diketide in the form of their biomimetic -acetylcysteamine thioesters.

Gauge Invariance of Equilibrium Statistical Mechanics.

We identify a recently proposed shifting operation on classical phase space as a gauge transformation for statistical mechanical microstates. The infinitesimal generators of the continuous gauge group form a noncommutative Lie algebra, which induces exact sum rules when thermally averaged. Gauge invariance with respect to finite shifting is demonstrated via Monte Carlo simulation in the transformed phase space which generates identical equilibrium averages.

Exploring Cationic Substitutions in the Solid Electrolyte NaAlCl with Density Functional Theory.

NaAlCl is an established solid electrolyte in high-temperature Na-based battery systems, but its ionic conductivity is not sufficiently high for room-temperature applications. We employ density functional theory and thermodynamic corrections to evaluate the efficacy of various elements for substitution, utilizing on-the-fly machine-learned potentials to accelerate the required phonon calculations by 1 order of magnitude at a minor error of -0.7 ± 1.

The 'Sandwich' meta-framework for architecture agnostic deep privacy-preserving transfer learning for non-invasive brainwave decoding.

. Machine learning has enhanced the performance of decoding signals indicating human behaviour. Electroencephalography (EEG) brainwave decoding, as an exemplar indicating neural activity and human thoughts non-invasively, has been helpful in neural activity analysis and aiding paralysed patients via brain-computer interfaces.

Why hyperdensity functionals describe any equilibrium observable.

We give an introductory account of the recent hyperdensity functional theory for the equilibrium statistical mechanics of soft matter systems (Sammüller2024098201). Hyperdensity functionals give access to the behaviour of arbitrary thermal observables in spatially inhomogeneous equilibrium many-body systems. The approach is based on classical density functional theory applied to an extended ensemble using standard functional techniques.

Microwave-assisted preparation of yeast cells for ultrastructural analysis by electron microscopy.

Budding yeast is widely used as a model organism to study the biogenesis and architecture of organellar membranes, which can be visualized by transmission electron microscopy (TEM). Preparation of yeast cells for TEM can be quite challenging and time-consuming. Here, we describe an optimized protocol for conventional fixation of yeast cells with potassium permanganate combined with cell wall permeabilization with sodium metaperiodate and embedding in Epon.

[Climate change and vector-borne disease-significance for intensive care and emergency medicine].

Tropical diseases are becoming increasingly important in medical care in Germany due to climate change and the spread of vectors and viruses. The widely distributed Culex mosquitoes in Germany can transmit the West Nile virus, which causes West Nile fever. Severe neuroinvasive disease courses with acute flaccid paralysis, meningitis, and encephalitis are possible.

Magnetic colloidal single particles and dumbbells on a tilted washboard moiré pattern in a precessing external field.

We measure the dynamical behavior of colloidal singlets and dumbbells on an inclined magnetic moiré pattern, subject to a precessing external homogeneous magnetic field. At low external field strength single colloidal particles and dumbbells move everywhere on the pattern: at stronger external field strengths colloidal singlets and dumbbells are localized in generic locations. There are however nongeneric locations of flat channels that cross the moiré Wigner Seitz cell.

Immiscible metamorphic water and methane fluids preserved in carbonated eclogite.

Subduction zones metamorphic fluids are pivotal in geological events such as volcanic eruptions, seismic activity, mineralization, and the deep carbon cycle. However, the mechanisms governing carbon mobility in subduction zones remain largely unresolved. Here we present the first observations of immiscible HO-CH fluids coexisting in retrograde carbonated eclogite from the Western Tianshan subduction zone, China.

A Catalytic Version of the Knorr Pyrrole Synthesis Permits Access to Pyrroles and Pyridines.

Aromatic -heterocycles, such as pyrroles and pyridines, are important natural products and bulk and fine chemicals with numerous applications as active ingredients of pharmaceuticals and agrochemicals, as catalysts, and in materials sciences. We report here a catalytic version of the Knorr pyrrole synthesis in which simple and diversely available starting materials, such as 1,2-amino alcohols or 1,3-amino alcohols and keto esters, undergo a dehydrogenative coupling to form pyrroles and pyridines, respectively. Our reaction forms hydrogen as a collectible (and usable) byproduct and is mediated by a well-defined Mn catalyst.

Neural density functionals: Local learning and pair-correlation matching.

Recently, Dijkman et al. [arXiv:2403.15007] proposed training classical neural density functionals via bulk pair-correlation matching.

Hydrophobic assembly of molecular catalysts at the gas-liquid-solid interface drives highly selective CO electromethanation.

Molecular catalysts offer tunable active and peripheral sites, rendering them ideal model systems to explore fundamental concepts in catalysis. However, hydrophobic designs are often regarded as detrimental for dissolution in aqueous electrolytes. Here we show that established cobalt terpyridine catalysts modified with hydrophobic perfluorinated alkyl side chains can assemble at the gas-liquid-solid interfaces on a gas diffusion electrode.

The Ni isotopic composition of Ryugu reveals a common accretion region for carbonaceous chondrites.

The isotopic compositions of samples returned from Cb-type asteroid Ryugu and Ivuna-type (CI) chondrites are distinct from other carbonaceous chondrites, which has led to the suggestion that Ryugu/CI chondrites formed in a different region of the accretion disk, possibly around the orbits of Uranus and Neptune. We show that, like for Fe, Ryugu and CI chondrites also have indistinguishable Ni isotope anomalies, which differ from those of other carbonaceous chondrites. We propose that this unique Fe and Ni isotopic composition reflects different accretion efficiencies of small FeNi metal grains among the carbonaceous chondrite parent bodies.

Age-dependent variation of aedeagal morphology in Agabusuliginosus and the status of A.lotti (Coleoptera, Dytiscidae).

A doubt has arisen about the taxonomic status of within the species group due to morphological similarities and lack of molecular data. In this study, a comprehensive morphological and molecular analysis of specimens from Central Europe was conducted, focusing on the Hungarian population. Morphological comparisons of genital structures revealed age-dependent variations, suggesting a gradual transition from to .

Phase transition kinetics of superionic HO ice phases revealed by Megahertz X-ray free-electron laser-heating experiments.

HO transforms to two forms of superionic (SI) ice at high pressures and temperatures, which contain highly mobile protons within a solid oxygen sublattice. Yet the stability field of both phases remains debated. Here, we present the results of an ultrafast X-ray heating study utilizing MHz pulse trains produced by the European X-ray Free Electron Laser to create high temperature states of HO, which were probed using X-ray diffraction during dynamic cooling.

[Stress fractures of the growth plates in the fingers of adolescent rock climbers].

Background: Primary periphyseal stress injuries (PPSI) of the hand and fingers are a rare condition overall but are most commonly seen in adolescent rock climbers and is the most common sport-specific injury in young climbers. Early diagnosis and treatment are crucial for a good treatment outcome and to avoid chronic sport-related injury.

Objective: The aim of the study is to introduce the injury to a wider audience.

Hyperdensity Functional Theory of Soft Matter.

We present a scheme for investigating arbitrary thermal observables in spatially inhomogeneous equilibrium many-body systems. Extending the grand canonical ensemble yields any given observable as an explicit hyperdensity functional. Associated local fluctuation profiles follow from an exact hyper-Ornstein-Zernike equation.

Plant Phytochrome Interactions Decode Light and Temperature Signals.

Plant phytochromes perceive red and far-red light to elicit adaptations to the changing environment. Downstream physiological responses revolve around red-light-induced interactions with phytochrome-interacting factors (PIF). Phytochromes double as thermoreceptors, owing to the pronounced temperature dependence of thermal reversion from the light-adapted Pfr to the dark-adapted Pr state.