7 results match your criteria: "Universitat Autonoma de Barcelona and Universitat Pompeu Fabra[Affiliation]"
Biofactors
November 2022
Department of Dermatology, Hospital del Mar, Universitat Autònoma de Barcelona and Universitat Pompeu Fabra, Barcelona, Spain.
The objective of the study was to assess the pathogenic and treatment relevance of Platelet Activating factor (PAF) in chronic spontaneous urticaria (CSU). The expression and cellular location of PAF receptor (PAFR) and serum levels of PAF and PAF acetylhydrolase (PAF-AH) in patients with moderate/severe CSU (n = 45) and healthy controls (HCs, n = 17) were studied. Skin samples from the active wheal (LS-CSU, 13 samples for qPCR and 33 for immunohistochemistry) and non-lesional skin (NLS-CSU, 13 samples) of CSU patients and HCs (13 samples and 5 for immunohistochemistry) were analyzed.
View Article and Find Full Text PDFOpen Forum Infect Dis
January 2020
Melinta Therapeutics, Lincolnshire, Illinois, USA.
Background: The clinical and economic burden of community-acquired bacterial pneumonia (CABP) is significant and is anticipated to increase as the population ages and pathogens become more resistant. Delafloxacin is a fluoroquinolone antibiotic approved in the United States for the treatment of adults with acute bacterial skin and skin structure infections. Delafloxacin's shape and charge profile uniquely impact its spectrum of activity and side effect profile.
View Article and Find Full Text PDFDrug Metab Dispos
February 2015
Bioanalysis Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Hospital del Mar Medical Research Institute, Barcelona, Spain (O.J.P.); Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain (M.I., J.V.S., F.H.); Human Pharmacology and Clinical Neurosciences Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Hospital del Mar Medical Research Institute, Universitat Autònoma de Barcelona and Universitat Pompeu Fabra, Barcelona, Spain (J.L.-B., M.F., E.P., R.d.l.T.); and Warwick Systems Biology Centre, University of Warwick, Coventry, United Kingdom (J.L.-B.).
In recent years, many new designer drugs have emerged, including the group of cathinone derivatives. One frequently occurring drug is mephedrone; although mephedrone was originally considered as a "legal high" product, it is currently banned in most Western countries. Despite the banning, abuse of the drug and seizures are continuously reported.
View Article and Find Full Text PDFInnate lymphoid cells (ILCs) regulate stromal cells, epithelial cells and cells of the immune system, but their effect on B cells remains unclear. Here we identified RORγt(+) ILCs near the marginal zone (MZ), a splenic compartment that contains innate-like B cells highly responsive to circulating T cell-independent (TI) antigens. Splenic ILCs established bidirectional crosstalk with MAdCAM-1(+) marginal reticular cells by providing tumor-necrosis factor (TNF) and lymphotoxin, and they stimulated MZ B cells via B cell-activation factor (BAFF), the ligand of the costimulatory receptor CD40 (CD40L) and the Notch ligand Delta-like 1 (DLL1).
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
January 2014
Department of Orthopaedic Surgery, Hospital del Mar-Parc de Salut Mar, Universitat Autonoma de Barcelona and Universitat Pompeu Fabra, Passeig Marítim 25-29, 08003, Barcelona, Spain,
Purpose: The purpose of this study was to report a comprehensive literature review on the risk factors for anterior cruciate ligament (ACL) injuries in male athletes.
Methods: All abstracts were read and articles of potential interest were reviewed in detail to determine on inclusion status for systematic review. Information regarding risk factors for ACL injuries in male athletes was extracted from all included studies in systematic fashion and classified as environmental, anatomical, hormonal, neuromuscular, or biomechanical.
J Epidemiol Community Health
October 2002
Institut Municipal d'Investigació Mèdica, Universitat Autònoma de Barcelona and Universitat Pompeu Fabra, Barcelona, Spain.
Cancer Lett
December 2000
Unitat de Biologia Cellular i Molecular, Institut Municipal d'Investigació Mèdica, Universitat Autònoma de Barcelona and Universitat Pompeu Fabra, Barcelona, Spain.
Small cell lung cancer (SCLC) expresses neuroectodermal markers including HuD, the best characterized member of the Hu gene family. The aim of this study is to optimize a simple and sensitive reverse transcriptase-polymerase chain reaction assay to detect circulating HuD-expressing cells for the early detection of SCLC recurrences. HuD-specific primers that selectively amplify the three HuD isoforms allowed the detection of one tumor cell/10(6) non-tumor cells.
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