Exploring the potential of in Alzheimer's disease treatment: An approach.

Objectives: Alzheimer's disease (AD) is posing an increasing global threat and currently lacks effective treatments. Therefore, this study was aimed at exploring phytochemicals in () as inhibitors of acetylcholinesterase (AChE), β-site APP cleavage enzyme 1 (BACE1), and TNF-α converting enzyme (TACE) in AD. contains various bioactive compounds, such as chlorogenic acid, linalool, and catechins, which are known for their detoxification properties, capacity to resist and manage harmful moisture buildup, and therapeutic roles in COVID-19.

Play Behavior Varies with Age, Sex, and Socioecological Context in Wild, Immature Orangutans ( spp.).

Unlabelled: Play is thought to serve different purposes at different times during ontogeny. The nature and frequency of play are expected to change accordingly over the developmental trajectory and with socio-ecological context. Orangutans offer the opportunity to disentangle the ontogenetic trajectories of solitary and social play with their extended immature phase, and socio-ecological variation among populations and species.

Immunoinformatic of novel self-amplifying mRNA vaccine lipid nanoparticle against SARS-CoV-2.

We developed innovative self-amplifying mRNA (sa-mRNA) vaccine based on the derivative of S and Nsp3 proteins, which are considered crucial adhering to human host cells. We performed B-cell, Major histocompatibility complex (MHC) I, and II epitope which were merged with the KK and GPGPG linker. We also incorporated 5' cap sequence, Kozak sequence, replicase sequence, 3'/5' UTR, and poly A tail within the vaccine structure.

Vocal complexity in the long calls of Bornean orangutans.

Vocal complexity is central to many evolutionary hypotheses about animal communication. Yet, quantifying and comparing complexity remains a challenge, particularly when vocal types are highly graded. Male Bornean orangutans () produce complex and variable "long call" vocalizations comprising multiple sound types that vary within and among individuals.

Active self-treatment of a facial wound with a biologically active plant by a male Sumatran orangutan.

Although self-medication in non-human animals is often difficult to document systematically due to the difficulty of predicting its occurrence, there is widespread evidence of such behaviors as whole leaf swallowing, bitter pith chewing, and fur rubbing in African great apes, orangutans, white handed gibbons, and several other species of monkeys in Africa, Central and South America and Madagascar. To the best of our knowledge, there is only one report of active wound treatment in non-human animals, namely in chimpanzees. We observed a male Sumatran orangutan (Pongo abelii) who sustained a facial wound.

Design and performance evaluation of an off-grid hybrid solar system in a remote location: A case study of Legundi Island.

Legundi Island, located in Lampung Bay, Indonesia, has high solar energy potential but still relies on Diesel Power Plants. This research aims to design a hybrid Solar Power Plant and Diesel Power plant system that is environmentally friendly and reliable. Analysis was conducted using the Homer software.

Impacts of fire and prospects for recovery in a tropical peat forest ecosystem.

Uncontrolled fires place considerable burdens on forest ecosystems, compromising our ability to meet conservation and restoration goals. A poor understanding of the impacts of fire on ecosystems and their biodiversity exacerbates this challenge, particularly in tropical regions where few studies have applied consistent analytical techniques to examine a broad range of ecological impacts over multiyear time frames. We compiled 16 y of data on ecosystem properties (17 variables) and biodiversity (21 variables) from a tropical peatland in Indonesia to assess fire impacts and infer the potential for recovery.

Investigating technology development in the energy sector and its implications for Indonesia.

Innovations for a low-carbon economy and carbon neutrality are the focal points of technology development in the energy sector. This paper aims to investigate the progress of technology and advancements in the energy sector and the implications for Indonesia via two routes, viz., renewable energy and energy efficiency.

Flanged males have higher reproductive success in a completely wild orangutan population.

Male orangutans (Pongo spp.) exhibit bimaturism, an alternative reproductive tactic, with flanged and unflanged males displaying two distinct morphological and behavioral phenotypes. Flanged males are larger than unflanged males and display secondary sexual characteristics which unflanged males lack.

Orangutan males make increased use of social learning opportunities, when resource availability is high.

Humans' colonization of diverse habitats relied on our ancestors' abilities to innovate and share innovations with others. While ecological impacts on innovations are well studied, their effect on social learning remains poorly understood. We examined how food availability affects social learning in migrant orangutan unflanged males, who may learn from local orangutans through peering (i.

Growth performance of Indonesian three-breed cross chicken associated with growth hormone and insulin-like growth factor 2 genes.

Background And Aim: Poultry, such as chickens, is an important source of animal protein, producing eggs and meat. Local chickens are able to adapt to the hot weather and become more resistant to disease. However, it has relatively slow growth and low egg production.

Wild and captive immature orangutans differ in their non-vocal communication with others, but not with their mothers.

Abstract: In many group-living species, individuals are required to flexibly modify their communicative behaviour in response to current social challenges. To unravel whether sociality and communication systems co-evolve, research efforts have often targeted the links between social organisation and communicative repertoires. However, it is still unclear which social or interactional factors directly predict communicative complexity.

Reproductive success of Bornean orangutan males: scattered in time but clustered in space.

Abstract: The social and mating systems of orangutans, one of our closest relatives, remain poorly understood. Orangutans ( spp) are highly sexually dimorphic and females are philopatric and maintain individual, but overlapping home ranges, whereas males disperse, are non-territorial and wide-ranging, and show bimaturism, with many years between reaching sexual maturity and attaining full secondary sexual characteristics (including cheek pads (flanges) and emitting long calls). We report on 21 assigned paternities, among 35 flanged and 15 unflanged, genotyped male Bornean orangutans (), studied from 2003 to 2018 in Tuanan (Central Kalimantan, Indonesia).

Immune status of people living in the Tande-Tande sub-village (Indonesia), an area with high indoor radon concentration.

On Earth, there are significant variations in terms of exposure to naturally occurring radiation among different areas. Radon, a naturally-occurring radioactive gas that is the primary cause of lung cancer in nonsmokers and the second most prevalent cause among smokers, poses a considerable risk. Indoor radon, in particular, constitutes the most substantial source of natural radiation to which individuals are exposed.

γ-H2AX and phospho-ATM enzyme-linked immunosorbent assays as biodosimetry methods for radiation exposure assessment: a pilot study.

In the event of a radiological incident, a fast and accurate biological dosimetry (biodosimetry) method for evaluating people who have been potentially exposed to ionising radiation is crucial. Among the many biodosimetry methods available, the immunodetection of phosphorylated H2AX (γ-H2AX) stands as a promising method to be used in the triage of patients exposed to radiation. Currently, the most common way to measure γ-H2AX levels is through fluorescence microscopy.

The inflammation process of gout arthritis and its treatment.

Gout arthritis is an inflammatory condition that occurs suddenly in joints affected by high uric acid levels (hyperuricemia). The uric acid levels in this disease fluctuate throughout its various phases, resulting in frequent or recurrent attacks. This study aims to review some aspects of gout arthritis, such as its pathophysiology, treatment goals, and adverse drug reactions.

Ecological, social, and intrinsic factors affecting wild orangutans' curiosity, assessed using a field experiment.

The readiness to interact with and explore novel stimuli-i.e., curiosity-is the cornerstone of innovation.

Sea swimming and snorkeling in tropical coastal blue spaces and mental well-being: Findings from Indonesian island communities during the COVID-19 pandemic.

Unlabelled: The COVID-19 pandemic has considerable mental health impacts. Immersive nature-based interventions, such as swimming or snorkeling, may help mitigate the global mental health crisis caused by the pandemic. To investigate this, we collected cross-sectional data from residents of coastal villages (n = 308) in Kepulauan Selayar, Indonesia.

Additively Manufactured Parts from AA2011-T6 Large-Diameter Feedstocks Using Friction Stir Deposition.

The current work investigates the possibility of fabricating additive manufacturing products in solid-state form, from AA2011-T6 of 40 mm diameter rods as a feedstock, using an additive friction stir deposition (A-FSD) technique. The use of large diameter feedstocks, especially high-strength aluminum alloys (2XXX series), is a challenge, as it necessitates high power and the critical selection of the optimal A-FSD parameters, such as feed rate and spindle rotation speed. The study included applying a wide range of spindle rotation speeds, ranging from 400 to 1200 rpm, at three levels of feeding rates of 1, 3, and 5 mm/min.

Alternative reproductive tactics of unflanged and flanged male orangutans revisited.

In many slowly developing mammal species, males reach sexual maturity well before they develop secondary sexual characteristics. Sexually mature male orangutans have exceptionally long periods of developmental arrest. The two male morphs have been associated with behavioral alternative reproductive tactics, but this interpretation is based on cross-sectional analyses predominantly of Northwest Sumatran populations.

Wildfire smoke linked to vocal changes in wild Bornean orangutans.

Tropical peatlands are the sites of Earth's largest fire events, with outsized contributions to greenhouse gases, toxic smoke, and haze rich with particulate matter. The human health risks from wildfire smoke are well known, but its effects on wildlife inhabiting these ecosystems are poorly understood. In 2015, peatland fires on Borneo created a thick haze of smoke that blanketed the region.

LCF and HCF of Short Carbon Fibers Reinforced AE42 Mg Alloy.

Lightweight magnesium alloys and magnesium matrix composites have recently become more widespread for high-efficiency applications, including automobile, aerospace, defense, and electronic industries. Cast magnesium and magnesium matrix composites are applied in many highly moving and rotating parts, these parts can suffer from fatigue loading and are consequently subjected to fatigue failure. Reversed tensile-compression low-cycle fatigue (LCF) and high-cycle fatigue (HCF) of short fibers reinforced and unreinforced AE42 have been studied at temperatures of 20 °C, 150 °C, and 250 °C.

Mother-offspring proximity maintenance as an infanticide avoidance strategy in bornean orangutans (Pongo pygmaeus wurmbii).

Sexually-selected infanticide by males is widespread across primates. Maternal protection is one of many infanticide avoidance strategies employed by female primates. Bornean orangutan (Pongo pygmaeus wurmbii) mothers with younger offspring are less social with males than mothers with older offspring.