Cytoskeletal regulation on polycaprolactone/graphene porous scaffolds for bone tissue engineering.

Understanding cellular mechanics requires evaluating the mechanical and chemical cues that regulate the actin cytoskeleton, particularly filopodia and lamellipodia. Therefore, this study aims to investigate the effect of scaffolds properties on cell migration. The results showed that scaffolds toughness, strain, and strength played a key role in promoting cell movement by stimulating the dynamic formation of filopodia and lamellipodia.

Addressing diversity and multicultural competence in integrative counseling for oncology patients: A commentary on Klafke et al.

This correspondence builds upon the significant findings presented by Klafke et al. regarding the qualitative analysis of interprofessional patient-nurse-physician. interactions in counseling lifestyle medicine in oncology.

In silico and in vitro Characterizations of Rodent Tuber (Typhonium flagelliforme) Mutant Plant Isolates against FXR Receptor on MCF-7 Cells.

Typhonium flagelliforme (T. flagelliforme) is an Indonesian rodent tuber plant traditionally used to treat cancer diseases. Although gamma-ray irradiation has been used to increase the content in the chemical compounds of the T.

NMR-based metabolic profiling and antioxidant activity of ethanol extract.

The metabolite profile of the ethanol extract from was assessed using the 1D NMR approach amalgamated with 2D NMR. an indigenous plant found in Indonesia, possesses considerable promise as a raw material for medicinal products. We examined the antioxidant capacity of the extract using DPPH and ABTS methods.

Acute toxicity, secondary metabolites, and antioxidant activity of from post-coal mining and non-mining areas in East Kalimantan, Indonesia.

Coal plays a crucial role in Indonesia's foreign exchange and East Kalimantan's revenue sharing, yet its environmental impacts, including soil acidification, raises concerns. Reclamation measures involve revegetation with pioneer plants such as ., known for their medicinal properties.

A promising poly (e-caprolactone)/graphene-based scaffold as an antibacterial in regenerating bone tissue.

Scaffolds are 3D biomaterials that provide an environment for cell regeneration. In the context of bone remodeling, poly(e-caprolactone) (PCL) combined with graphene has been developed as the scaffold. It is imperative for scaffolds to possess antibacterial properties in order to properly reduce the risk of potential infections.

Pharmacological evaluation of anti-inflammatory, antipyretic, analgesic, and antioxidant activities of leaf fractions (water, ethyl acetate, and -hexane fractions): the potential medicinal plants from North Sumatra, Indonesia.

Background And Purpose: Inflammation, fever, and pain can be associated with several diseases, and the synthetic drugs used in the treatment of these conditions often have severe side effects. As a result, there is a need for effective, economical, and safe alternative drugs, such as those derived from medicinal plants. Therefore, this study aimed to evaluate the anti-inflammatory, antipyretic, analgesic, and antioxidant activities of leaf fractions (CcLF), as well as its acute toxicity.

Total synthesis of [β-HIle]-nodupetide: effect of ester to amide substitution on its antimicrobial activity.

The increasing prevalence of deaths due to multidrug-resistant bacteria (MDRB) in infectious disease therapy has become a global health concern. This led to the development of new antimicrobial therapeutic agents that can combat resistance to pathogenic bacteria. The utilization of natural peptide compounds as potential antimicrobial agents is very promising.

Evaluation of the antiplasmodial and anti-Toxoplasma activities of several Indonesian medicinal plant extracts.

Ethnopharmacological Relevance: Malaria, caused by Plasmodium parasites, remains a significant global health challenge, particularly in tropical and subtropical regions. At the same time, the prevalence of toxoplasmosis has been reported to be 30% worldwide. Traditional medicines have long played a vital role in discovering and developing novel drugs, and this approach is essential in the face of increasing resistance to current antimalarial and anti-Toxoplasma drugs.

and King fruit peel extract: Secondary metabolite composition, antioxidant, and elastase inhibitory activity evaluation.

and King are native plants from Indonesia and have tremendous potential as a source of raw medicines based on local wisdom. However, scientific data for strengthening pharmaceuticals are still limited. Therefore, it is necessary to conduct a study to strengthen and develop the potential of both plants using the approach of traditional medicine.

In Vitro Anti-Inflammatory Study of Limonoids Isolated from Plants.

plants from the family Meliaceae have traditionally been used to treat several diseases; however, scientific evidence is limited. The most abundant chemical constituents of this plant are the limonoids, which are known for their various biological activities, including anti-inflammatory effects. However, the anti-inflammatory effects and underlying mechanisms of action of the constituents of plants have not been fully explored.

Kappaphycus alvarezii as a renewable source of kappa-carrageenan and other cosmetic ingredients.

Kappa-carrageenan is one of the most traded marine-derived hydrocolloids used in the food-and-beverage, pharmaceuticals, and personal care/cosmetics industries. K. alvarezii (previously known as Kappaphycus alvarezii) is arguably the most important natural producer based on annual production size and near-homogeneity of the product (i.

New Insight of Scaffold Based on Hydroxyapatite (HAp)/Bacteria's Nanocellulose (BN) for Dental Tissue Engineering.

Objective:  Bacterial nanocellulose (BN), derived from ATCC 237672, is a polymer that offers several desirable characteristics for scaffolds applications. To further enhance the characteristic of the BN scaffold, hydroxyapatite (HAp) from and can be incorporated. Therefore, the aim of the study was to characterize the physical properties of a three-dimensional (3D) scaffold made of HAp and BN.

Natural Deep Eutectic Solvent based Ultrasound-assisted extraction: A green approach for extraction of sulfhydryl and mimosine from (Lam) de Wit seeds.

(Lam.) de Wit seeds, also known as river tamarind, contain sulfhydryl compounds that exhibit antioxidant effects. However, these seeds also possess a toxic effect from mimosine.

Coarse-grained molecular dynamics-guided immunoinformatics to explain the binder and non-binder classification of Cytotoxic T-cell epitope for SARS-CoV-2 peptide-based vaccine discovery.

Epitope-based peptide vaccine can elicit T-cell immunity against SARS-CoV-2 to clear the infection. However, finding the best epitope from the whole antigen is challenging. A peptide screening using immunoinformatics usually starts from MHC-binding peptide, immunogenicity, cross-reactivity with the human proteome, to toxicity analysis.

Quality Control and Authentication of Black Betel Leaf Extract ( Blume) from East Kalimantan as an Antimicrobial Agent Using a Combination of High-Performance Liquid Chromatography and Chemometric Fourier Transform Infrared.

Black betel leaf from East Kalimantan contains various secondary metabolites such as alkaloid saponins, flavonoids, and tannins. A compound, piperenamide A, which has antimicrobial activity, is also found in black betel leaf. This study aims to identify and authenticate the compound piperenamide A found in black betel leaf extract in other types of betel plant using HPLC and FTIR-chemometrics.

Retrofitting of concrete for rigid pavement using bacterial: A meta-analysis.

Cracking in tension causes damage to regular concrete. When the surface of the concrete cracks, liquids can enter and damage the structure. Remediating concrete in rigid pavements is time-consuming, costly, and challenging.

Uniportal vats approach to bronchogenic cyst, East Borneo experience: A case report.

Introduction: Abnormalities in the development of the ventral foregut may result in bronchogenic cysts. Depending on the extent of aberrant budding, the location of a bronchogenic cyst might vary. The location and, more crucially, the size of the mass determine the onset of symptoms in individuals with bronchogenic cysts.

The Cytotoxic Activity of Dammarane-Type Triterpenoids Isolated from the Stem Bark of (Meliaceae).

The genus, a member of the Meliaceae family, is generally recognized to include a number of secondary metabolite compounds with diverse structures and biological activities, including triterpenoids. Among the members of this genus, has been reported to have unique properties and thrives exclusively in mangrove ecosystems. This plant is also known to contain various metabolites, such as flavaglines, bisamides, and diterpenoids, but there are limited reports on the isolation of triterpenoid compounds from its stem bark.

Optimization of microwave-assisted extraction on polyphenol metabolite from (Mill.) urb. bulbs using response surface methodology.

bulbs, an endemic plant in Indonesia, have enormous potential as raw materials for pharmaceutical products. Therefore, it is necessary to strengthen and develop extraction methods that are easy, rapid, and efficient to enrich targeted secondary metabolites. This study aims to optimize the microwave-assisted extraction (MAE) method conditions for polyphenol metabolite from bulbs.