Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders.

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed by the current treatments. This review explores the emerging role of bile acids and the TGR5 receptor in the pathophysiology of psychiatric conditions, emphasizing their signaling within the gut-brain axis. We detail the synthesis and systemic functions of bile acids, their transformation by gut microbiota, and their impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety disorder, schizophrenia, autism spectrum disorder, and bipolar disorder.

Challenges and recommendations in the implementation of audiovisual telemedicine communication: a systematic review.

This systematic review aims to identify the elements of doctor-patient communication in telemedicine, emerging challenges, and proposed recommendations. Four databases, including Science Direct, PubMed, Cochrane, and ProQuest, were searched using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The inclusion criteria consisted of original research papers, availability of free full text, and publications during the past 10 years.

Targeting Circadian Protein Rev-erbα to Alleviate Inflammation, Oxidative Stress, and Enhance Functional Recovery Following Brain Trauma.

Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide, and its pathophysiology is characterized by oxidative stress and inflammation. Despite extensive research, effective treatments for TBI remain elusive. Recent studies highlighted the critical interplay between TBI and circadian rhythms, but the detailed regulation remains largely unknown.

A Scoping Review of Tabletop Role-Playing Game (TTRPG) as Psychological Intervention: Potential Benefits and Future Directions.

Purpose: The present study aimed to investigate how prior research of TTRPG revealed the benefits of TTRPG as a psychological intervention and how further studies can overcome the challenges and limitations of TTRPG in those previous studies.

Methods: The study used Scoping Review to explore the potential benefits of TTRPG. Three research questions were identified (1) the extent to which empirical research has been conducted regarding TTRPG as intervention, (2) the potential of TTRPG mentioned, and (3) the suggestions for future research.

Complete neurological recovery of spinal tuberculosis after spinal surgery and vitamin D supplementary: A case series.

Introduction And Importance: Deaths from tuberculosis (TB) in Indonesia are nearly 200,000 per year and higher than those from COVID-19. The problems associated with spinal TB are vitamin D deficiency, neurological deficit, disruption of daily living activities and long-term anti-TB treatment (24 months). Vitamin D acts as an anti-inflammatory, maintains vascular health, and increases calcium levels.

Unveiling the veil: exploring how wellbeing motivations shape anonymous and public prosocial behavior in Indonesia.

Indonesia is often regarded as a country with a strong inclination toward prosocial behavior, with both public and anonymous acts of kindness being commonplace. However, there is a notable gap in related research regarding the predictors of such behaviors. Previous studies have highlighted how individuals with diverse motives for wellbeing are inclined to either assist or hinder others.

How inter-ethnic relations are reproduced through everyday social practices: A perspective from the Javanese nasi pecel vendors in Mataraman cities.

There is growing scholarship on how ethnic groups with historical tensions recover and manage to build harmonious relationships. However, detailed accounts of the lived experiences of such relations are limited. We seek to address this gap by exploring everyday inter-ethnic relations between Javanese and Chinese Indonesians in Indonesia as exemplified in the practice of selling nasi pecel, the traditional food of Mataraman cities in East Java.

Letter to the Editor. Re: "[Indigenous dataset of Dayak, Malay, and Chinese communities in Sintang Regency, West Kalimantan, Indonesia by A. Gandasari et al., Data in Brief, 2024, 53, 110147]".

Gandasari and colleagues [1] open an important opportunity for us to consider how social scientists might contribute to preserving Indigenous cultures in Indonesia. The focus of these authors was on releasing for open use Indigenous data collected from Dayak, Malay, and Chinese communities in Sintang Regency, West Kalimantan, Indonesia. In this commentary, we respond to key issues raised by Gandasari and colleagues [1] to engage in a productive discussion regarding the broader ethical considerations and implications of publishing such Indigenous datasets in academic journals.

pH-dependent stability of major betalains in the encapsulated beetroot extracts (Beta vulgaris L.).

Betalain is a water-soluble pigment contained in Caryophyllales plants. It not only holds potential as a natural food colorant but also offers various health benefits, acting as an antioxidant. This study focused on analyzing the pH-dependent stability of encapsulated betalain pigments extracted from red beetroot (Beta vulgaris L.

The association between social support with compliance of IFA supplement intake among adolescent girls in Sidoarjo, Indonesia.

Anemia is a severe nutritional issue affecting people worldwide, including in Indonesia. One of the government's initiatives to alleviate anemia afflicting adolescent Indonesian girls is iron and folic acid supplementation (IFAS). However, this program has shown to be ineffective, which may be due to poor compliance of IFAS.

Retinal Vein Occlusion Amongst People Vaccinated by mRNA- and Viral Vector- COVID-19 Vaccines: A Systematic Review.

Vaccines are highly effective in lowering the mortality due to COVID-19. Although several suspected adverse events or side effects after vaccination including retinal vein occlusion (RVO) have been reported. We conducted a systematic review using PRISMA methods to analyze the occurrence of RVO among people vaccinated by COVID-19 mRNA- vs viral vector- vaccines on 4 databases from 1-1-2021 to 31-12-2022 using specified MeSH terms.

Patient Safety Culture, Infection Prevention, and Patient Safety in the Operating Room: Health Workers' Perspective.

Introduction: A hospital's patient safety culture affects surgical outcomes. Operating room safety culture has been overlooked despite the importance of patient safety. The AHRQ's Hospital Survey on Patient Safety Culture (HSOPSC) has been used worldwide to assess and enhance patient safety culture.

Could Purpose in Life Help Unmotivated Students to Thrive? When Motivation and Purpose in Life Matter for Peer Mentoring.

Purpose: The present study investigated the effect of extrinsic motivation, amotivation, the presence of and search for purpose, and their interaction effects on the perceived positive outcomes of being a peer mentor in college.

Methods: We tested a cross-sectional data using correlation design and moderation model. Participants were 232 undergraduate students who served as mentors for freshmen.

Antibodies against native proteins of Mycobacterium tuberculosis can detect pulmonary tuberculosis patients.

Accurate point-of-care testing (POCT) is critical for managing tuberculosis (TB). However, current antibody-based diagnosis shows low specificity and sensitivity. To find proper antigen candidates for TB diagnosis by antibodies, we assessed IgGs responsiveness to Mycobacterium tuberculosis proteins in pulmonary TB (PTB) patients.

Mental Health Status and Its Associated Factors Related to Pulmonary Tuberculosis Patients in Primary Health Care Centre in Surabaya, Indonesia.

Background: Mental disorders in TB patients are due to long-term treatment, drug side effects, and relapse. This study aimed to analyse the mental health status among TB patients and its associated factors.

Methods: The study was carried out on 107 Pulmonary TB patients from 5 Primary Healthcare centres in Surabaya, Indonesia.

New value creation and family business sustainability: Identification of an intergenerational conflict resolution strategy.

Unresolved tensions frequently lead to the failure of family businesses. Parents and their children should be able to work together to resolve protracted problems. This study intends to explore the intergenerational conflict resolution strategy in an effort to develop new family business values and ensure the sustainability of family enterprises.

Health Workers' Perspective on Patient Safety Incident Disclosure in Indonesian Hospitals: A Mixed-Methods Study.

Purpose: This study examined how health staff in Indonesian hospitals perceived open disclosure of patient safety incidents (PSIs).

Patients And Methods: This study employed a mixed method explanatory sequential approach. We surveyed 262 health workers and interviewed 12 health workers.

Compliance of Iron Supplementation and Determinants among Adolescent Girls: A Systematic Review.

Background: Iron deficiency anemia in children or women in pregnancy, is a public health problem in some countries. The World Health Organization (WHO) has called on all countries to achieve a 5% reduction in anemia in women of childbearing age, including adolescent girls, by 2025. One of the programs is iron supplementation.

The role of social support and interpersonal trust to improve compliance of iron supplementation amongst adolescent girls: A qualitative approach.

Context: Adolescence is a crucial phase in preventing and controlling anaemia. One of the efforts made by the Indonesian government to overcome adolescent girl's anaemia is the iron and folic acid (IFA) supplementation programme. This programme is one of the most effective interventions that various countries have used to overcome anaemia.

Star intrapreneurs:characteristics of Indonesian corporate entrepreneurs.

Global competition has been driving many companies globally, including in Indonesia, to develop intrapreneurship within their organizations. The current study offers the concept of star intrapreneurs to examine the intrapreneur character scale which operates at the individual level within the cultural context of Indonesia. The concept of intrapreneurship in this study consisted of two dimensions: the person and the interaction.