Characterization and in vitro anticancer study of PEGylated liposome dually loaded with ferulic acid and doxorubicin.

Doxorubicin is an anthracycline antibiotic widely used in cancer therapy. However, its cytotoxic properties affect both cancerous and healthy cells. Combining doxorubicin with antioxidants such as ferulic acid reduces its side effects, while simultaneously enhancing therapeutic effectiveness.

Associations between tooth loss, denture use, and dementia in older Taiwanese adults.

Background: The literature has mainly focused on the association between tooth loss and dementia, and evidence regarding the separate and joint effects of tooth loss and denture use on the risk of dementia is limited. This study investigated the links among tooth loss, denture use, and dementia risk in Taiwanese adults aged 65 years or older.

Methods: This retrospective cohort study utilized data from the 2009 National Health Interview Survey and 2008-2017 National Health Insurance claim records, including the records of 2247 individuals free from dementia treatment in 2008-2009.

The Herpes Zoster Patient Pathway and Gaps in Current Vaccination Guidelines in Southeast Asia: Summary of a Zoster Experts' Network Scientific Workshop.

The burden of herpes zoster (HZ) is recognized worldwide; however, there is seemingly limited information on incidence and vaccination practices in Southeast Asia (SEA). A scientific workshop was held by the Zoster Experts' Network to exchange and consolidate insights on the burden of HZ and the patient pathway in SEA. The workshop included practicing clinical experts and public health specialists/epidemiologists from Indonesia, Malaysia, the Philippines, Thailand, and Vietnam.

The Role of Complete Blood Count-Derived Inflammatory Biomarkers as Predictors of Infection After Acute Ischemic Stroke: A Single-Center Retrospective Study.

: Although a wide range of hematological parameters are used as blood-based inflammatory biomarkers, the role of complete blood count-derived inflammatory biomarkers in infection after acute ischemic stroke (AIS) is modest. Therefore, this study aimed to explore complete blood count-derived inflammatory biomarkers as predictors of infection after AIS. : A single-center retrospective cross-sectional study was carried out at the National Brain Center Hospital Prof.

Greater return to sports after anterior cruciate ligament reconstruction combined with anterolateral ligament reconstruction compared with anterior cruciate ligament reconstruction alone: A systematic review and meta-analysis.

Purpose: This study aimed to compare the return to sports, return to competition, Tegner score and anterior cruciate ligament-return to sports injury (ACL-RSI) scores between patients who underwent ACL reconstruction (ACLR) combined with anterolateral ligament reconstruction (ALLR) and those who underwent ACLR alone.

Methods: Two independent reviewers conducted a literature search in PubMed (MEDLINE), EMBASE, Google Scholar and the Cochrane Library in July 2024, followed by data extraction and quality assessment. This study followed the Preferred Reporting Items for Systematic Reviews and meta-analysis guidelines.

Geospatial Access to Emergency Obstetric Surgery in Indonesia: Is Travel Time for Access Too Long?

Ensuring timely access to safe and affordable surgery within a travel time of a 2‑h drive or 30‑min walk is crucial for achieving universal health coverage, as endorsed by the Lancet Commission on Global Surgery (LCoGS). In this study, we aimed to quantify the percentage of Indonesian women of reproductive age (WRA) who can access a hospital with emergency obstetric and gynecological services within this time frame. In addition, we aimed to identify the underserved populations.

Calcium Carbonate from Anadara granosa Shells Stimulates FGF2, TGF-β1, and Collagen Type 1 Expression in Rat Dental Pulp.

Objectives:  Calcium carbonate (CaCO), a major inorganic component in bones and teeth, offers potential protection against demineralization. This study investigates the effect of CaCO from shells on the expression of fibroblast growth factor 2 (FGF2), transforming growth factor-β1 (TGF-β1), and collagen type 1 in the rat dental pulp.

Materials And Methods:  The first maxillary molars of were perforated and subsequently pulp capped with CaCO extracted from shells.

Exploring the Changes in Mild Cognitive Impairment Blood-Based Biomarkers after Local Antibiotic Periodontal Treatment in Diabetic Patients: Secondary Analysis of Data from a Randomized Controlled Trial.

Objectives:  This article investigates the changes in blood-based biomarkers associated with mild cognitive impairment (MCI) risk in type 2 diabetic patients following local antibiotic periodontal treatment.

Materials And Methods:  A secondary analysis of data from a 24-week randomized controlled trial was conducted, involving 27 patients with type 2 diabetes mellitus and periodontitis. Participants received periodontal treatment biweekly from baseline until the 6th week of the study.

Development and validation of trigger tools in primary care: A scoping review.

In primary care, trigger tools have been utilized to evaluate and identify patient safety events. The use of trigger tools could help clinicians and patients detect adverse events in a patient's medical record. Due to a lack of research on the process development of trigger tools in primary care, the purpose of this scoping review is to investigate the trigger development and validation process in primary care settings.

The Role of Moisturizer Containing Anti-inflammatory on Skin Hydration in Mild-Moderate Atopic Dermatitis Patients.

Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by eczema lesions and dry, itchy skin. Recent guidelines for the management of AD emphasize the importance of using moisturizers in the management of AD. This study is a double-blind clinical trial to determine the effectiveness of moisturizers containing anti-inflammatory ingredients compared with moisturizers without anti-inflammatory ingredients for skin hydration in mild to moderate adult AD patients for 14 days at the Dermatology and Venereology Outpatient Clinic at Dr.

Effect of leaf extract and its active components on heart muscle cell apoptosis induced by hyperglycemia.

Background: Hyperglycemia is a condition in which blood sugar levels increase excessively due to a variety of factors, one of which is the body's inability to regulate insulin properly. Diabetes closely relates to this condition, which significantly contributes to premature death and disability. Long-term diabetes treatment accompanied by a strict diet provides real results in controlling blood glucose levels but can cause side effects.

Detection of the methicillin-resistant gene encoding in nasal swabs of cats in Surabaya, Indonesia.

Background: The most susceptible group of people to spread methicillin-resistant (MRSA) among domestic cats is their owners' relatives.

Aim: Considering the aforementioned, research at the Surabaya City Animal Hospital is necessary to determine whether the A gene may be detected in cat nasal swabs.

Methods: Samples were taken using a sterile cotton swab, and the transport medium was buffered peptone water.

A comprehensive review of paratuberculosis in animals and its implications for public health.

Paratuberculosis is an infectious disease caused by subspecies (MAP). Typically, ruminant animals including cattle, buffalo, goats, and sheep are infected with MAP. Animals get infected with MAP in a number of ways, such as by eating or drinking contaminated food or water, or by nursing from an infected mother who may have contaminated teats or directly shed the organism in milk or colostrum.

Bovine trichomoniasis: A hidden threat to reproductive efficiency.

Bovine trichomoniasis is a reproductive illness that affects cattle causing pyometra, early to mid-pregnancy miscarriages, and lower birth rates. is a flagellated protozoan which first discovered in France in 1888 and composts three phases during its lifecycle including trophozoite, cyst, and pseudocyst. In addition, several factors contributed to the prevalence of trichomoniasis and fall into three categories are management, cow, and bull-related factors.

Ultrastructural morphology of second and third-stage larvae of inside paratenic host tissue.

Background: is a known cause of a zoonotic infectious illness called toxocariasis. Parathenic hosts are important as they can transmit larvae 2 (L) through direct transmission. Scanning electron microscope (SEM) techniques are needed to provide a three-dimensional image of each stage of larvae.

Development of peptone-based serum-free media to support Vero CCL-81 cell proliferation and optimize SARS-CoV2 viral production.

Background: Developing an optimal media for Vero cell lines is crucial as it directly influences cell survival, proliferation, and virus production. The use of serum in cell culture raises safety concerns in biological production. The United States Food and Drug Administration (FDA) and the European Medicines Agency have implemented stricter regulations on the use of animal-derived components in commercial protein manufacturing to ensure patient safety.

Estimation of the wetting induced settlement of loess soils from the wetting soil-water characteristic curve.

Collapsible loess soils, known for their significant volume reduction upon the wetting, pose critical challenges in the geotechnical engineering. The estimation of the wetting-induced settlement is crucial for the foundation design and the determination of the negative skin friction on the pile. In this paper, a new method is proposed to estimate the wetting induced collapse from the wetting soil-water characteristic curve (SWCC) and the index properties of the loess soils.

Massive hydropyonephrosis on pediatric patient: A case report of management and source control.

Introduction And Importance: Dilation and stretching of the collecting system of the kidney due to obstruction of urine flow is called hydronephrosis. This case may be accompanied by the presence of pus known as pyonephrosis. This case report reporting massive pyonephrosis in pediatrics related to management and source of control.

Positive deviance/hearth intervention in collaboration between academia and NGOs: a realist evaluation.

Numerous NGOs and donors from high-income countries (HICs) offer diverse funding to assist LMICs. A collaborative effort in nutrition programs in urban communities was conducted by an international NGO with a local university, representing the NGO's first mode of partnership with academia. This study used realist evaluation to understand how and why Positive Deviance/Hearth intervention conducted by NGOs collaborated with university work or failed to work in urban population.

Characterization of a biocomposite film using coconut jelly powder to improve arrowroot starch and sodium alginate film forming properties.

Composite polymers are promising solution to structural setbacks of starch and alginate-based films due to their hydrophilic attributes. Hence, this study aimed to investigate young coconut jelly powder (CJP), an under-utilized by-waste, as a filler using the casting method to develop a novel biocomposite from increments of CJP (1-3 %) to a blended resin of arrowroot starch, sodium alginate, and glycerol. Moreover, the films were characterized by physicomechanical (visual aspect, thickness, color, moisture content, tensile strength, and elongation at break); surface microstructure; water barrier (water vapor permeability, water solubility, and water activities); thermal, crystallinity, and functional group properties; soil, river water, and seawater biodegradability; and coating application in cherry tomato.

Absenteeism and Productivity Loss Due to Influenza or Influenza-like Illness in Adults in Europe and North America.

Healthy working-age adults are susceptible to illness or caregiving requirements resulting from annual seasonal influenza, leading to considerable societal and economic impacts. The objective of this targeted narrative review is to understand the societal burden of influenza in terms of absenteeism and productivity loss, based on the current literature. This review includes 48 studies on the impact of influenza and influenza-like illness (ILI) and reports on the effect of influenza vaccination, age, disease severity, caring for others, comorbidities, and antiviral prophylaxis on absenteeism and productivity loss due to influenza/ILI, focusing on publications originating from Canada, Europe, and the United States.

Mental Health Literacy Among Female Community Health Workers: A Multi-setting Cross-sectional Study.

Background: Mental health literacy among lay community health workers (CHWs) is crucial to ensuring that mental health services are accessible to all. This research explores the mental health literacy of community health workers in Indonesia.

Methods: A cross-sectional study was carried out among 454 female community health workers from various villages.