Novel frameshift variants expand the map of the genetic defects in IRF2BP2.

Background: At present, the knowledge about disease-causing mutations in IRF2BP2 is very limited because only a few patients affected by this condition have been reported. As previous studies have described, the haploinsufficiency of this interferon transcriptional corepressors leads to the development of CVID. Very recently, a more accurate phenotype produced by truncating variants in this gene has been defined, manifesting CVID with gastrointestinal inflammatory symptoms and autoimmune manifestations.

Adjunctive Treatment with Interferon Alpha 2b in Conjunctival Melanoma.

Purpose: The aim of the study was to demonstrate the clinical outcomes after resection of conjunctival melanoma (CM) followed by topical interferon (IFN) alpha 2b after a long follow-up.

Methods: Two consecutive CM patients were treated using tumor excision followed by topical IFN alpha 2b (1,000,000 UI/mL) four times a day for 12 weeks. The second case presented positivity due to the presence of tumor cells in the lower margin of the resection.

Corneal endothelial cell density during diabetes mellitus and ocular diabetes complications treatment.

Diabetes mellitus may affect the cornea at various levels. Ocular surface changes and dry eye had been studied. Researchers are concerned that medical treatment of diabetes or retinal complications may result in endothelial damage and cell loss.

Calculation of iris-claw IOL power for correction of late in-the-bag IOL complex dislocation.

Background: To assess the constants and formula for aphakia correction with iris-claw IOLs to achieve the best refractive status in cases of late in-the-bag IOL complex dislocation.

Methods: A literature search was performed. The following data were obtained: Iris-claw IOL model, Iridal or retroiridal enclavation, A-constant, ultrasound or optical biometry, formula employed and refractive outcomes.

Pseudophakic cystoid macular edema: update 2016.

Pseudophakic cystoid macular edema (PCME) is the most common complication of cataract surgery, leading in some cases to a decrease in vision. Although the pathogenesis of PCME is not completely understood, the contribution of postsurgical inflammation is generally accepted. Consequently, anti-inflammatory medicines, including steroids and nonsteroidal anti-inflammatory drugs, have been postulated as having a role in both the prophylaxis and treatment of PCME.

Evaluation of the Ex-PRESS(®) P-50 implant under scleral flap in combined cataract and glaucoma surgery.

Aim: To evaluate the efficacy and safety of glaucoma drainage device Ex-PRESS(®) P-50 for combined cataract surgery and glaucoma.

Methods: Patients having cataract and open angle glaucoma or patients with open advanced glaucoma which needed two or more antiglaucoma medications were included. Combined cataract surgery and glaucoma with Ex-PRESS(®) P-50 model placed under scleral flap was performed.

Infectious crystalline keratopathy caused by Pseudomonas fluorescens.

Objective: To demonstrate a case of infectious crystalline keratopathy (ICK) caused by Pseudomonas fluoresecens (PF).

Methods: Case report description.

Results: A 15-year-old female contact lens wearer presented complaining of eye pain and redness in the left eye.

Piggyback multifocal IOLs for a hyperopic-presbyopic surprise after cataract surgery in high myopic patients.

Purpose: To demonstrate the utility of piggyback multifocal intraocular lenses (IOLs) for a hyperopic-presbyopic surprise after cataract surgery in highly myopic patients.

Methods: Case report.

Results: A 43-year-old woman with high myopia presented with dense subcapsular cataracts.

Pleomorphic adenoma with extensive myoepithelial component (myoepithelioma) of the lower eyelid.

A 58-year-old woman presented with a nodular lesion on the medial part of her left lower eyelid. The lesion had been removed 10 years ago, but showed subsequent recurrence with slow growth. The lesion was again partially removed at another institution prior to presentation.

Lattice corneal dystrophy type II: clinical, pathologic, and molecular study in a Spanish family.

Purpose: To report a family with lattice corneal dystrophy type II (LCD II) associated with systemic amyloidosis type V.

Methods: A 69-year-old woman presented a LCD II and marked dermachalasis. A lower blepharoplasty was performed.