2,949 results match your criteria: "Universitaria Pisana[Affiliation]"
Clin Microbiol Infect
December 2024
Department of Clinical and Experimental Medicine, Infectious Diseases Unit, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy; StopTB Italia ODV, Milan, Italy. Electronic address:
Background: Advanced HIV disease (AHD) is increasing, with late presentation accounting for half of newly diagnosed people with HIV (PWH) in Europe. Mortality in late-presenting PWH remains high, and Mycobacterium avium complex (MAC) disease, among other opportunistic infections, presents several diagnostic and treatment challenges that lead, ultimately, to a poor clinical outcome.
Objectives: We aimed to provide guidance on the diagnosis and treatment of disseminated MAC disease (dMACd) in PWH.
Clin Microbiol Infect
August 2024
Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Italy. Electronic address:
Background: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are associated with high mortality rates. Optimal antibiotic dosage plays a crucial role in reducing MRSA burden; thus, the use of therapeutic drug monitoring (TDM) in the clinical practice, especially of new drugs such as ceftobiprole, ceftaroline, dalbavancin, and oritavancin, should be implemented.
Objectives: We aim to examine and summarize the available evidence about TDM of anti-MRSA molecules, with a focus on pneumonia, endocarditis and vascular infections, and bone and joint infections.
Seizure
October 2024
Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
EuroIntervention
August 2024
Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
Genes (Basel)
July 2024
Department of Human Pathology of Adulthood and Childhood G. Barresi, University of Messina, 98125 Messina, Italy.
Brain Sci
July 2024
Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), 56100 Pisa, Italy.
Background: Lumbar foraminal stenosis (LFS) involves the narrowing of neural foramina, leading to nerve compression, significant lower back pain and radiculopathy, particularly in the aging population. Management includes physical therapy, medications and potentially invasive surgeries such as foraminotomy. Advances in diagnostic and treatment strategies are essential due to LFS's complexity and prevalence, which underscores the importance of a multidisciplinary approach in optimizing patient outcomes.
View Article and Find Full Text PDFEur Heart J Cardiovasc Imaging
December 2024
HerzZentrum Hirslanden, Hirslanden Clinic, Zurich, Switzerland.
Invest Ophthalmol Vis Sci
August 2024
Department of Biology, University of Pisa, Pisa, Italy.
Purpose: In response to hypoxia, sympathetic fibers to the retina activate β-adrenoceptors (β-ARs) that play an important role in the regulation of vascular and neuronal functions. We investigated the role of β3-AR using the mouse model of oxygen-induced retinopathy (OIR).
Methods: Mouse pups were exposed to 75% oxygen at postnatal day 7 (PD7) followed by a return to room air at PD12.
Eur Heart J Cardiovasc Imaging
November 2024
Cardiac Intensive Care Unit, Heart Center, Copenhagen University Hospital, Rigshospitalet and Clinical Institute Copenhagen University, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Dig Liver Dis
December 2024
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Unit of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Background: Most patients receiving atezolizumab-bevacizumab (AB) for hepatocellular carcinoma will eventually experience disease progression. Randomized clinical trials (RCTs) are undergoing to identify second-line treatments. Where RCTs are unavailable or patients are non-eligible, sorafenib is often prescribed based on approval and reimbursement policies.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2024
Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
Surgery
December 2024
Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy; Department of Surgery, University Hospital Southampton NHS, United Kingdom. Electronic address:
Am J Gastroenterol
August 2024
Centre for Oesophageal Diseases, Guy's and St. Thomas Hospital, London, UK.
Expert Opin Pharmacother
August 2024
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Introduction: Oncogenic tyrosine kinases (TK) are enzymes that play a key role in cell growth and proliferation and their mutations can lead to uncontrolled cell growth and development of aggressive cancer. This knowledge has led to the development of new classes of drugs, Tyrosine kinase inhibitors (TKI). They target oncogenic kinases who are associated with advanced radioactive iodine (RAI) refractory TC, which is not able to uptake RAI anymore and/or still grows between consecutive treatments with Iodine 131 (I131).
View Article and Find Full Text PDFAtherosclerosis
October 2024
Fondazione Pisana per la Scienza ONLUS, San Giuliano Terme (PI), Italy. Electronic address:
Background And Aims: Lipids constitute one of the main components of atherosclerosis lesions and are the mediators of many mechanisms involved in plaque progression and stability. Here we tested the hypothesis that lipids known to be involved in plaque development exhibited associations with plaque vulnerability. We used spatial lipidomics to overcome plaque heterogeneity and to compare lipids from specific regions of symptomatic and asymptomatic human carotid atherosclerotic plaques.
View Article and Find Full Text PDFJ Anesth Analg Crit Care
August 2024
Department of Anesthesia and Intensive Care, University Hospital of Modena, Modena, Italy.
Eur Heart J Cardiovasc Imaging
November 2024
Cardiovascular Department, Fondazione Toscana Gabriele Monasterio, Via G. Moruzzi 1, Pisa 56126, Italy.
Curr Opin Infect Dis
December 2024
Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy.
Purpose Of Review: To correlate the resistance mechanisms and the susceptibility to new antibiotics in Pseudomonas aeruginosa .
Recent Findings: Definition of antibiotic resistance in Pseudomonas aeruginosa is still debated. Carbapenem-resistant Pseudomonas aeruginosa (CRPA) and difficult-to-treat resistant Pseudomonas aeruginosa (DTR-PA) are used but which of them better correlate with the risk of mortality remains debated.
Br J Oral Maxillofac Surg
October 2024
Maxillofacial Surgery Unit Terni, "Santa Maria" Hospital, V.le Tristano di Joannuccio, 05100, Terni, Italy.
We know of few studies in the international scientific literature that specifically address the evaluation of surgical and clinical progress among physicians undergoing specialist training in maxillofacial surgery. Identifying a reliable tool to accurately assess both theoretical knowledge and surgical skills of trainees is essential. The primary aim of this study therefore was to design a comprehensive assessment tool that is capable of evaluating both the theoretical and practical skills of physicians undergoing specialist training in maxillofacial surgery.
View Article and Find Full Text PDFSci Transl Med
August 2024
Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, 75006 Paris, France.
Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam binding inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that is secreted in a nonconventional, autophagy-dependent fashion. Here, we show that low ACBP/DBI plasma concentrations are associated with poor prognosis in patients with anorexia nervosa, a frequent and often intractable eating disorder. In mice, anorexia induced by chronic restraint stress (CRS) is accompanied by a reduction in circulating ACBP/DBI concentrations.
View Article and Find Full Text PDFAnn Oncol
October 2024
Medical Oncology Department, Vall d'Hebron Hospital Campus, Barcelona, Spain; Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. Electronic address:
Seizure
October 2024
IRCCS Istituto delle Scienze Neurologiche di Bologna, U.O.C. Neuropsichiatria dell'età pediatrica, Member of the ERN EpiCare, Bologna, , Italy; Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy. Electronic address:
ACS Appl Mater Interfaces
August 2024
Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy.
Head and neck squamous cell carcinomas are characterized by a high incidence of recurrence, especially in patients with locally advanced disease. Standard treatment strategies can be associated with severe side effects to healthy tissues that can negatively impact the patient's quality of life. Hyperthermia (HT) is a noninvasive treatment modality that has improved the effectiveness of chemotherapy (CT) and/or radiotherapy (RT) for the management of some solid neoplasms.
View Article and Find Full Text PDFNeurol Sci
January 2025
Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.