Impact of functionalized particle structure on roll compaction/dry granulation and tableting of calcium carbonate.

The influence of a functionalized raw material particle structure on the granulation behavior and tabletabilty of calcium carbonate (CaCO) was investigated. Therefore, a milled grade of CaCO was compared to different binary mixtures of milled and functionalized CaCO. Relevant properties of raw materials, ribbons and granules were measured.

Development of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation.

Raman spectroscopy was evaluated as a process analytical technology (PAT) tool for continuous API quantification during twin-screw wet granulation. Therefore, a Raman probe was implemented in front of the granulator barrel. This setup enabled the collection of Raman spectra upon a constant granule flow.