Endangering the integrity of science by misusing unvalidated models and untested assumptions as facts: General considerations and the mineral and phosphorus scarcity fallacy.

Unlabelled: There is increasing demand for science to contribute to solving societal problems (solutionism). Thereby, scientists may become normative activists for solving certain problems (advocacy). When doing this, they may insufficiently differentiate between scientific and political modes of reasoning and validation (de-differentiationism), which is sometimes linked to questionable forms of utilizing the force of facts (German: ).

Impact of Different Scan Bodies and Scan Strategies on the Accuracy of Digital Implant Impressions Assessed with an Intraoral Scanner: An In Vitro Study.

Purpose: Sufficient data are not currently available on how the various geometries of scan bodies and different scan strategies affect the quality of digital impressions of implants. The purpose of this study was to present new data on these two topics and give clinicians a basis for decision making.

Materials And Methods: A titanium master model containing three Nobelreplace Select™ implants (Nobelbiocare Services AG, Zurich, Switzerland) was digitized using an ATOS industrial noncontact scanner.

DAPK1 loss triggers tumor invasion in colorectal tumor cells.

Colorectal cancer (CRC) is one of the leading cancer-related causes of death worldwide. Despite the improvement of surgical and chemotherapeutic treatments, as of yet, the disease has not been overcome due to metastasis to distant organs. Hence, it is of great relevance to understand the mechanisms responsible for metastasis initiation and progression and to identify novel metastatic markers for a higher chance of preventing the metastatic disease.

Epigenetic Regulation of p21 in Human Cancer.

p21 is a central regulator of cell cycle control and survival. While mutations are rare, it is commonly dysregulated in several human cancers due to epigenetic mechanisms influencing its transcriptional control. These mechanisms include promoter hypermethylation as well as additional pathways such as histone acetylation or methylation.

Hsp90 inhibition by AUY922 as an effective treatment strategy against myxoid liposarcoma.

Liposarcoma is one of the most common soft tissue sarcomas in adults. Recognized histological subtypes include well differentiated/dedifferentiated liposarcoma (WD/DDLS), myxoid liposarcoma (MLS) and pleomorphic liposarcoma. Currently, there are no proper subtype-specific treatments due to the genetic, histological and clinical heterogeneity of the liposarcoma subentities.

"The Dose Makes the Poison": Informing Consumers About the Scientific Risk Assessment of Food Additives.

Intensive risk assessment is required before the approval of food additives. During this process, based on the toxicological principle of "the dose makes the poison,ˮ maximum usage doses are assessed. However, most consumers are not aware of these efforts to ensure the safety of food additives and are therefore sceptical, even though food additives bring certain benefits to consumers.

High-resolution assessment of land use impacts on biodiversity in life cycle assessment using species habitat suitability models.

Agricultural land use is a main driver of global biodiversity loss. The assessment of land use impacts in decision-support tools such as life cycle assessment (LCA) requires spatially explicit models, but existing approaches are either not spatially differentiated or modeled at very coarse scales (e.g.

Reconstructing the 2003/2004 H3N2 influenza epidemic in Switzerland with a spatially explicit, individual-based model.

Unlabelled: world has not faced a severe pandemic for decades, except the rather mild H1N1 one in 2009, pandemic influenza models are inherently hypothetical and validation is, thus, difficult. We aim at reconstructing a recent seasonal influenza epidemic that occurred in Switzerland and deem this to be a promising validation strategy for models of influenza spread.

Methods: We present a spatially explicit, individual-based simulation model of influenza spread.

Development and validation of a short, consumer-oriented nutrition knowledge questionnaire.

A short scale was developed and validated that assesses consumers' knowledge about nutrition. Sixty-four nutrition knowledge items were derived from consumer interviews and expert recommendations about healthy eating. Items were administered as a postal survey to a sample of consumers randomly drawn from the directory (response rate=37%, N=1043).

A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spread.

Background: Mathematical models and simulations of disease spread often assume a constant per-contact transmission probability. This assumption ignores the heterogeneity in transmission probabilities, e.g.

Models of epidemics: when contact repetition and clustering should be included.

Background: The spread of infectious disease is determined by biological factors, e.g. the duration of the infectious period, and social factors, e.

Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics.

The search for inherited cancer susceptibility factors is a major focus of epidemiologic cancer studies. Analyses of single-nucleotide polymorphisms (SNP) in a variety of genes revealed a correlation between a specific allele variant and cancer predisposition. Human mouse double-minute 2 protein (Mdm2) is a cellular E3 ligase capable of ubiquitination and degradation of p53.

On-site testing of illicit drugs: the use of the drug-testing device "Toxiquick".

Since 1998, driving under the influence of drugs such as amphetamine, MDMA, MDE, cannabis, cocaine, heroine and morphine is sanctioned due to Section 24a of the Road Traffic Regulations of Germany. Therefore, from December 2000 to June 2002 altogether 751 roadside tests with the immunochemical test device Toxiquick were conducted on 302 drivers (273 male and 29 female) on oral fluid samples obtained during control actions in Franconia. The results of the tests are compared to the results obtained through quantification of corresponding blood samples by GC/MS.