Vegetable-Enriched Brownies: A Healthier Twist on a Classic Treat.

Background/objectives: In response to concerns about high-fat and low-fiber diets, this study modified a traditional brownie recipe by replacing butter with plant-based ingredients, including sweet potatoes, red beans, beetroot, zucchini, pumpkin, lentils, and spinach. The goal was to increase vegetable consumption while identifying the best vegetable fat replacer using sensory and instrumental analyses.

Methods: Chemical analyses were conducted to measure dry matter, protein, fat, ash, and dietary fiber, alongside texture, color, and sensory evaluations.

The Positive Effects of Training and Time-Restricted Eating in Gut Microbiota Biodiversity in Patients with Multiple Myeloma.

Background: The physical activity of different groups of individuals results in the rearrangement of microbiota composition toward a symbiotic microbiota profile. This applies to both healthy and diseased individuals. Multiple myeloma (MM), one of the more common hematological malignancies, predominantly affects older adults.

Innovative Application of Fermented Red Bean Seeds in Constructing Foods with Increased Biological Activity.

Legumes are an interesting matrix for food production. The aim of this study was to develop functional plant-based snacks using fermented red bean (RBB) seeds enriched with the following additives: marjoram-RBM (2%); carrot-RBC (30%); and red beetroot-RBRB (15%). In the process of constructing the snacks, the focus was on the maximum use of the raw material, including aquafaba, to improve nutritional properties, sensory acceptability, and biological activity.

Houtt. Transformed Hairy Root Cultures as an Effective Platform for Producing Phenolic Compounds with Strong Bactericidal Properties.

Houtt. is the source of various phenolic compounds: phenolic acids, flawan-3-ols, and stilbenes, with a broad range of biological activity. The rhizome (underground organ of these plants) is abundant in secondary metabolites but, in natural conditions, may accumulate various toxic substances (such as heavy metals) from the soil.

Maximal Intensity Exercise Induces Adipokine Secretion and Disrupts Prooxidant-Antioxidant Balance in Young Men with Different Body Composition.

Maximal physical effort induces a disturbance in the body's energy homeostasis and causes oxidative stress. The aim of the study was to determine whether prooxidant-antioxidant balance disturbances and the secretion of adipokines regulating metabolism, induced by maximal intensity exercise, are dependent on body composition in young, healthy, non-obese individuals. We determined changes in the concentration of advanced protein oxidation products (AOPP), markers of oxidative damage to nucleic acids (DNA/RNA/ox), and lipid peroxidation (LPO); catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity, as well as concentrations of visfatin, leptin, resistin, adiponectin, asprosin, and irisin in the blood before and after maximal intensity exercise in men with above-average muscle mass (NFAT-HLBM), above-average fat mass (HFAT-NLBM), and with average body composition (NFAT-NLBM).

Design and Characterization of Novel Polymeric Hydrogels with Protein Carriers for Biomedical Use.

Hydrogels are three-dimensional polymeric matrices capable of absorbing significant amounts of water or biological fluids, making them promising candidates for biomedical applications such as drug delivery and wound healing. In this study, novel hydrogels were synthesized using a photopolymerization method and modified with cisplatin-loaded protein carriers, as well as natural extracts of nettle () and chamomile ( L.).

Synthesis of New Promising BNCT Agents Based on Conjugates of -Dodecaborate Anion and Aliphatic Diamino Acids.

In this work, a series of boronated amidines based on the -dodecaborate anion and amino acids containing an amino group in the side chain of the general formula [BHNHC(NH(CH)CH(NH)COOH)CH], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino and α-carboxyl groups recognized by the binding centers of the large neutral amino acid transporter (LAT) system, which serves as a target for the clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several approaches to synthesizing the target compounds, their acute toxicity studies, and tumor uptake studies in vivo in two tumor models.

The Immunophenotype and the Odontogenic Commitment of Dental Pulp Stem Cells Co-Cultured with Macrophages Under Inflammatory Conditions Is Modulated by Complex Magnetic Fields.

Dental inflammatory diseases remain a challenging clinical issue, whose causes and development are still not fully understood. During dental caries, bacteria penetrate the tooth pulp, causing pulpitis. To prevent pulp necrosis, it is crucial to promote tissue repair by recruiting immune cells, such as macrophages, able to secrete signal molecules for the pulp microenvironment and thus to recruit dental pulp stem cells (DPSCs) in the damaged site.

Creep Resistance and Microstructure Evolution in P23/P91 Welds.

This paper summarizes the results of investigations into heterogeneous P23/P91 welds after long-term creep exposure at temperatures of 500, 550 and 600 °C. Two variants of welds were studied: In Weld A, the filler material corresponded to P91 steel, while in Weld B, the chemical composition of the consumable material matched P23 steel. The creep rupture strength values of Weld A exceeded those of Weld B at all testing temperatures.

Organic Optocoupler with Simple Construction as an Effective Linear Current Transceiver.

In this study, it is shown that an efficient organic optocoupler (OPC) can be fabricated using commercially available and solution-processable organic semiconductors. The transmitter is a single-active-layer organic light-emitting diode (OLED) made from a well-known polyparavinylene derivative, Super Yellow. The receiver is an organic light-emitting diode (OLSD) with a single active layer consisting of a mixture of the polymer donor PTB7-Th and the low-molecular-weight acceptor ITIC; the receiver operates without an applied reverse voltage.

Analyzing the Vibration Response of Adhesively Bonded Composite Cantilevers.

In this study, we investigated the vibration of adhesively bonded composite cantilevers consisting of two beech wood lamella and a bondline of flexible polyurethane. The beams had a constant total height, while the thickness of the adhesive layer varied. We analyzed both the driven and free vibration of a single cantilever beam and a cantilever with an additional mass attached to its end.

Analysis of Tool Wear in Finish Turning of Titanium Alloy Ti-6Al-4V Under Minimum Quantity Lubrication Conditions Observed with Recurrence Quantification Analysis.

Titanium alloys, particularly Ti-6Al-4V, are widely used in many industries due to their high strength, low density, and corrosion resistance. However, machining these materials is challenging due to high strength at elevated temperatures, low thermal conductivity, and high chemical reactivity. This study investigates Recurrence Plot (RP) and Recurrence Quantification Analysis (RQA) to analyze tool wear during the finish turning of Ti-6Al-4V.

Assessment of Radiological Safety of Ceramic Tiles Commonly Used in Polish Buildings.

The concentration of natural radionuclides Ra, Th and K in ceramic tiles manufactured in Poland is presented in this paper. The concentration of natural radioactive isotopes in the tested samples was determined using a low-level digital gamma ray spectrometer equipped with an HPGe semiconductor detector. The mean concentrations of Ra, Th and K in the analyzed samples were found to be 48 ± 3 Bq∙kg, 49 ± 3 Bq∙kg and 476 ± 23 Bq∙kg, respectively.

Experimental Determination of the Equivalent Moment of Inertia and Stresses of Aluminium Profiles with Thermal Breaks.

This paper presents the results of experimental tests and computer simulations on the stiffness of composite aluminium mullions used in unitised façades. The elements analysed were subjected to bending in order to simulate the actual operating conditions of aluminium façades subjected to significant wind pressure or suction loads. The basic mechanical and physical properties of the materials from which the analysed type of aluminium façade is made (Aluminium EN AW-6060 in the T66 temper and polyamide PA66 25GF), the test method, and the results obtained are described.

Near-Infrared Responsive Composites of Poly-3,4-Ethylenedioxythiophene with Fullerene Derivatives.

Electrochemical polymerization of 3,4-ethylenedioxythiophene in the presence of water-soluble fullerene derivatives was investigated. The electronic structure, morphology, spectroelectrochemical, electrochemical properties and near-IR photoconductivity of composite films of poly(3,4-ethylenedioxythiophene) with fullerenes were studied for the first time. It was shown that fullerene with hydroxyl groups creates favorable conditions for the formation of PEDOT chains and more effectively compensates for the positive charges on the PEDOT chains.

Functional Analysis of Durum Wheat GASA1 Protein as a Biotechnological Alternative Against Plant Fungal Pathogens and a Positive Regulator of Biotic Stress Defense.

Plants are frequently challenged by a variety of microorganisms. To protect themselves against harmful invaders, they have evolved highly effective defense mechanisms, including the synthesis of numerous types of antimicrobial peptides (AMPs). Snakins are such compounds, encoded by the (Gibberellic Acid-Stimulated Arabidopsis) gene family, and are involved in the response to biotic and abiotic stress.

Multilateral Use of Dandelion in Folk Medicine of Central-Eastern Europe.

Background: Dandelion ( sect. , also referred to as F.H.

Mechanistic Aspects of [3+2] Cycloaddition Reaction of Trifluoroacetonitrile with Diarylnitrilimines in Light of Molecular Electron Density Theory Quantum Chemical Study.

In this study, we investigated the [3+2] cycloaddition reaction of CFCN (TFAN) with nitrilimine (NI) to produce 1,2,4-triazole and compared the resulting isomers. We determined the preferred reaction pathway by examining the electrophilic and nucleophilic properties of the reaction substrates, performing thermodynamic calculations for the individual pathways, and comparing them with the experimental results.

Chiropractic international research collaborative (CIRCuit): the development of a new practice-based research network, including the demographics, practice, and clinical management characteristics of clinician participants.

Objectives: To describe the structure and development of a new international, chiropractic, practice-based research network (PBRN), the Chiropractic International Research Collaborative (CIRCuit), as well as the demographic, practice, and clinical management characteristics of its clinician participants. An electronic survey was used to collect information on their demographics, practice, and clinical management characteristics from clinicians from 17 October through 28 November 2022. Descriptive statistics were used to report the results.

The tree-ring width and interval trend values as indicators of sensitivity to temperature and precipitation in different provenances of European larch.

The study assessed the sensitivity of 20 provenances of European larch (Larix decidua Mill.) growing at provenance experimental trials located in lowland (Siemianice) and upland (Bliżyn) climate in Central Poland to air temperature and precipitation, including drought. The measure of the tree' sensitivity was their radial growth reactions, i.

The response of Petunia × atkinsiana 'Pegasus Special Burgundy Bicolor' to mechanical stress encompassing morphological changes as well as physiological and molecular factors.

In 1973, Jaffe identified and characterized the phenomenon of thigmomorphogenesis, also referred to as mechanical stress (MS) or mechanical stimulation in plants. Previous studies on petunia plants demonstrated that MS significantly affects growth dynamics. As a response to MS, petunias exhibit increased levels of indole-3-acetic acid (IAA) oxidase and peroxidase, although the active transport of endogenous IAA remains unaffected.

[When tuberculosis makes you deaf].

Introduction: Tuberculous otomastoiditis is a rare and serious infection that most often occurs in association with pulmonary involvement. It is easy to diagnose when the two pathologies are associated and isolated. We herein report the case of a patient initially hospitalized for Pseudomonas aeruginosa necrotising otitis externa (NOE), which delayed the diagnosis of tuberculous otomastoiditis.

Multiple plastid losses within photosynthetic stramenopiles revealed by comprehensive phylogenomics.

Ochrophyta is a vast and morphologically diverse group of algae with complex plastids, including familiar taxa with fundamental ecological importance (diatoms or kelp) and a wealth of lesser-known and obscure organisms. The sheer diversity of ochrophytes poses a challenge for reconstructing their phylogeny, with major gaps in sampling and an unsettled placement of particular taxa yet to be tackled. We sequenced transcriptomes from 25 strategically selected representatives and used these data to build the most taxonomically comprehensive ochrophyte-centered phylogenomic supermatrix to date.

Implementation of a novel method for the determination of plasma protein binding of highly bound compounds using the equilibrium dialysis method coupled with extraction to the organic phase and its comparison to known methods.

Accurate determination of plasma protein binding (PPB) is crucial in understanding the pharmacokinetics and pharmacodynamics of drugs, particularly for highly bound compounds where traditional methods may fall short. In this study, we present a pioneering approach for the precise determination of PPB that takes advantage of the lipophilicity of highly bound compounds. Twenty four highly bound compounds (with a fraction unbound (f) from 10 to 10) were tested with the most commonly used method, i.

EEG alpha activity as predictor for TBS-rTMS treatment outcome in depression.

Repetitive transcranial magnetic stimulation (rTMS) is an established psychiatric procedure for patients suffering from treatment-resistant depression (TRD). Biomarker identification to predict rTMS outcomes may assist the clinician in optimizing treatment selection. In recent years, different electrophysiological markers, in particular electroencephalographic (EEG) markers, were shown to yield discriminative power between responders and non-responders to various TRD treatments.