Use of letermovir in off-label indications: Infectious Diseases Working Party of European Society of Blood and Marrow Transplantation retrospective study.

Letermovir (LMV) is licensed for prophylaxis of CMV infection in allogeneic hematopoietic cell transplant adult CMV-seropositive patients. Due to its favorable safety profile, LMV brings potential for use in other clinical situations, outside the approved indication. The objective of the study was to analyze the efficacy and safety of the use of LMV in off-label indications in EBMT centers.

The First Organ-Based Ontology for Arthropods (Ontology of Arthropod Circulatory Systems - OArCS) and its Integration into a Novel Formalization Scheme for Morphological Descriptions.

Morphology, the oldest discipline in the biosciences, is currently experiencing a renaissance in the field of comparative phenomics. However, morphological/phenotypic research still suffers on various levels from a lack of standards. This shortcoming, first highlighted as the "linguistic problem of morphology", concerns the usage of terminology and also the need for formalization of morphological descriptions themselves, something of paramount importance not only to the field of morphology but also when it comes to the use of phenotypic data in systematics and evolutionary biology.

Nervous system development in Spinicaudata and Cyclestherida (Crustacea, Branchiopoda)--comparing two different modes of indirect development by using an event pairing approach.

Cladocera are the ecologically most important group within the Branchiopoda. They are unquestionably branchiopods but their evolutionary origin remains unclear. One favored explanation of their origin is that they evolved from a reproductive larva of a clam shrimp-like ancestor.

Experimental investigations of the insertion and deformation behavior of press-fit and threaded acetabular cups for total hip replacement.

Background: The deformation behavior of threaded and press-fit acetabular cups in correlation with the applied torques and forces to insert the cups has not been widely investigated. The aim of this experimental study was to analyze the deformation behavior of threaded (BICON-PLUS) and press-fit (EP FIT PLUS and Metal shell) acetabular cup designs during insertion and extraction with regard to the possibility of cup failure.

Methods: The experiments were carried out using artificial bone and human acetabular bone.

Pitfalls in the use of acetabular reinforcement rings in total hip revision.

Introduction: For the reconstruction of acetabular bone defects different types of acetabular reinforcement rings are being used. In clinical practice, these implants showed to some extent good long-term results. In the present work pitfalls and complications after the implantation of acetabular reinforcement rings as well as possible solutions are being discussed.