Supporting the continuous development and use of a patient partnership framework in European rare disease networks (ERNs): a scoping review of frameworks in the scientific literature.

The European Reference Networks (ERNs) for rare and complex diseases offer significant potential for building, maintaining and evaluating patient partnership, for which the recently developed ERN Patient Partnership Framework may serve as guidance. This scoping review aims to identify and describe relevant frameworks published in scientific literature, capturing key learning points to inform future updates of the ERN Patient Partnership Framework and promote its use in practice. MEDLINE, Embase, and the Web of Science Core Collection were searched to identify recently published frameworks (2013-2023) focused on patient partnership and aligned with at least one core ERN activity.

Active and passive material response of urinary bladder smooth muscle tissue in uniaxial and biaxial tensile testing.

The urinary bladder is a hollow organ that undergoes significant deformation as it receives, stores, and releases urine. To understand the organ mechanics, it is necessary to obtain information about the material properties of the tissues involved. In displacement-controlled tensile tests, tissue samples are mounted on a device that applies stretches to the tissue in one or more directions, resulting in a specific stress response.

Age-friendly community environments and the age trajectories of long-term care dependency among Chinese older adults.

In the context of rapid global aging, the importance of age-friendly community environments for promoting healthy aging and "aging in place" continues to increase. Using data from the 2011-2020 China Health and Retirement Longitudinal Study, this study investigated the impact of an age-friendly community environment on the age trajectories of late-life long-term care (LTC) dependency among older Chinese adults aged 60+ years. Age-friendly community environments were defined according to three levels (poor, moderate, or good) based on the World Health Organization's age-friendly city and community framework, and LTC dependency was classified as level 1 (high), level 2 (medium), or level 3 (low) according to activities of daily living and instrumental activities of daily living scores.

Unraveling the Bonding and Aromaticity of Pentazole, Pentaphosphole, and Cyclopentadiene Anions: A Comprehensive Study.

This study investigates π-delocalization, π-bonding situations, and aromaticity of the pentazolate anion ([cyclo-N], ()), which was detected by Christe in 2002. To gain a broader perspective, we investigated the iso-π-electronic species [cyclo-P] () and [cyclo-(CH)] (). VB analyses reveal that the three studied molecules display significant resonance stabilization, as indicated by their high resonance energy values.

Bending Moiré in Twisted Bilayer Graphene.

Moiré potentials caused by lattice mismatches significantly alter electrons in two-dimensional materials, inspiring the discovery of numerous unique physical properties. While strain modulates the structure and symmetry of the moiré potential, serving as a tuning mechanism for interactions, the impact of out-of-plane deformation, e.g.

Scalable production of ultraflat and ultraflexible diamond membrane.

Diamond is an exceptional material with great potential across various fields owing to its interesting properties. However, despite extensive efforts over the past decades, producing large quantities of desired ultrathin diamond membranes for widespread use remains challenging. Here we demonstrate that edge-exposed exfoliation using sticky tape is a simple, scalable and reliable method for producing ultrathin and transferable polycrystalline diamond membranes.

Toward a resilience selection index with indicator traits in German Holstein dairy cattle.

Resilience expresses the ability of an individual to cope with short-term disturbances and to recover quickly by returning to the original level of performance. It can be measured by variance-based parameters and by the autocorrelation of daily milk yields in dairy cows. The design of resilience indicator traits and their heritabilities and genetic correlations have been studied in detail in recent years.

Rehabilitation after surgical release of the stiff elbow: A literature review.

Background: Elbow stiffness poses a significant challenge for surgeons as well as physiotherapists during and after surgery. To date, there is no consensus regarding the subsequent rehabilitation after surgical release of the stiff elbow.

Objective: The aim is to evaluate the most important therapeutic strategies following open or arthroscopic release of the stiff elbow based on a comprehensive literature review, and to develop a consensus for or against specific therapeutic methods with the help of a survey among elbow experts of the D-A-CH Association for Shoulder and Elbow Surgery (DVSE).

Increasing incidence of mycotoxicosis in South-Eastern Germany: a comprehensive analysis of mushroom poisonings at a University Medical Center.

Background: Mushrooms, an integral component of human diets, range from esteemed delicacies to potentially lethal toxins. The risk of severe poisoning from misidentified species, poses a significant challenge. For clinicians, recognizing mushroom poisoning amidst nonspecific symptoms and determining the specific mushroom ingested are critical yet complex tasks.

The origin and evolution of shrews (Soricidae, Mammalia).

Shrews are among the most speciose of mammalian clades, but their evolutionary history is poorly understood. Their fossil record is fragmentary and even the anatomy of living groups is not well documented. Here, we incorporate the oldest, most complete fossil shrew yet known into the first phylogenetic analysis of the group to include molecular, morphological and temporal data.

Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.

Background: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.

Methods: Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance imaging, or nonimaging exercise tolerance test.

[Rehabilitative short-term care (REKUP): acceptance and practicability of a new care concept].

Background: Rehabilitative short-term care (REKUP) is aimed at geriatric patients in need of rehabilitation but not (yet) capable of rehabilitation after acute inpatient hospitalization with a positive rehabilitation prognosis. It was tested at two geriatric rehabilitation clinics from October 2020 to March 2022.

Objective: Qualitative process evaluation with respect to acceptance (service providers, health insurance), adoption (implementation at the start of the project), practicability (processes, contents, structures) and observed patient satisfaction.

The Ukrainian version of the Perceived Injustice Questionnaire: A psychometric evaluation.

Introduction: Perceived injustice is increasingly recognized as a key factor influencing mental health in war survivors. This cross-sectional study aimed to evaluate the psychometric properties of the Ukrainian translation of the Perceived Injustice Questionnaire (PIQ) among individuals directly exposed to the war in Ukraine.

Methods: 170 war-exposed Ukrainians completed the Ukrainian PIQ and measures of post-traumatic tress disorder (PCL-5), depression (PHQ-9), generalized anxiety disorder (GAD-7), and potentially traumatic life events (LEC-5).

Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial.

Background: Rhabdomyosarcoma and other soft tissue sarcomas (STS) with high-risk features are still associated with an unsatisfactory outcome. We evaluated the efficacy of oral maintenance therapy added at the end of standard therapy in patients with high-risk rhabdomyosarcoma and STS.

Methods: CWS-2007-HR was a multicentre, open-label, randomised controlled, phase 3 trial done at 87 centers in 5 countries.

Interdisciplinary Fascia Therapy: A Proof-of-Concept Pilot Study for a New Myofascial Approach for Chronic Low Back Pain.

Chronic low back pain (CLBP) is highly prevalent and relevant in all medical fields. This study evaluated the safety and effectiveness of interdisciplinary fascia therapy (IFT) for CLBP, focusing on its potential to reduce pain intensity, disability, and regulate autonomic nervous system (ANS) activity. Nine participants with CLBP each underwent nine sessions of IFT, twice weekly.

[Geriatric traumatology-Principles of orthogeriatrics].

The number of patients with fragility fractures will continue to increase in the future. The multimorbidity of these patients places high demands on the treatment. The treatment of this complex group of patients in specialized centers is therefore recommended.

The selective estrogen receptor modulator clomiphene inhibits sterol biosynthesis in Arabidopsis thaliana.

Sterols are produced via complex, multistep biosynthetic pathways involving similar enzymatic conversions in plants, animals and fungi, yielding a variety of sterol metabolites with slightly different chemical properties to exert diverse and specific functions. A tremendously diverse landscape of sterols, and sterol-derived compounds, can be found across the plant kingdom, determining a wide spectrum of functions. Resolving the underlying biosynthetic pathways is thus instrumental to understanding the function and use of these molecules.

Calcium Chemistry as A New Member of Post-Lithium Battery Family: What Can We Learn from Sodium and Magnesium Systems.

The development of next-generation battery technologies needs to consider their environmental impact throughout the whole cycle life, which has brought new chemistries based on earth-abundant elements into the spotlight. Rechargeable calcium batteries are such an emerging technology, which shows the potential to provide high cell voltage and high energy density close to lithium-ion batteries. Additionally, the use of Ca as a charge carrier renders significant sustainable values.

Synthesis and Characterization of Novel Perfluoro Aromatic Side Chain Sulfonated PSU Ionomers.

Polyethersulfone (PSU) as a commercially available polymer offers many different opportunities for functionalization for diverse fields of application, for example, electrophilic substitutions like sulfonation and bromination or nucleophilic reactions such as lithiation. This study presents three different polysulfone derivatives, first functionalized by a lithiation reaction, followed by a reaction with carbonyl compounds containing pentafluorophenyl groups. In the last step, the pentafluorophenyl moieties of the modified PSU were sulfonated by thiolation and subsequent oxidation to sulfonic acid groups.

Rethinking the physiological cross-sectional area of skeletal muscle reveals the mechanical advantage of pennation.

The shape of skeletal muscle varies remarkably-with important implications for locomotor performance. In many muscles, the fibres are arranged at an angle relative to the tendons' line of action, termed the pennation angle. These pennate muscles allow more sarcomeres to be packed side by side, enabling the muscle to generate higher maximum forces for a given muscle size.

Structural characterization of surface immobilized platinum hydrides by sensitivity-enhanced Pt solid state NMR spectroscopy and DFT calculations.

Supported single-site platinum hydride compounds are promising heterogeneous catalysts for organic transformations. Few methods exist to describe the structures of single-site Pt catalysts with atomic resolution because of their disordered structures and low Pt loadings. Here, we study the compounds formed when bis(tri--butylphosphino)platinum, Pt(P Bu), is supported on dehydroxylated SiO or SiO-AlO.