Outcomes of Mechanical Thrombectomy in Patients With Acute Basilar Artery Occlusion With Mild to Moderate Symptoms.

Background And Objectives: The benefit of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) with basilar artery occlusion (BAO) and a baseline National Institute of Health Stroke Scale (NIHSS) score <10 is unclear because this subpopulation has been substantially excluded from large clinical trials. The aim of our study was to determine whether MT ± IV thrombolysis (IVT) improves functional outcomes compared with IVT alone in patients with BAO and a NIHSS score <10.

Methods: We emulated a hypothetical trial including adult patients with BAO, a baseline NIHSS score <10, and prestroke modified Rankin scale (mRS) scores 0-2, comparing MT (±IVT) with IVT alone.

Two birds with one stone: Degradation of pharmaceuticals and elimination of bacteria upon treatment of urban wastewater with a Fenton-like process, based on zero-valent iron at pH 4.

ZVI-Fenton, which is the combination of zero-valent iron (metallic Fe) and HO is a relatively cheap advanced oxidation process for the elimination of contaminants from wastewater. Here we experimentally tested the ZVI-Fenton reaction at pH 4 towards two crucial goals in the treatment of secondary (partially treated) urban wastewater: (i) degradation of pharmaceuticals such as anti-inflammatory drugs (ibuprofen) and antibiotics (cefazolin, sulfamethoxazole), and (ii) elimination of a considerable fraction of bacteria through a combination of acidic pH and strongly oxidising conditions. In detail, ZVI-Fenton at pH 4 achieved degradation of both primary contaminants and potentially problematic transformation intermediates.

Stroke thrombectomy in the elderly: A propensity score matched study on a nationwide real-world registry.

Introduction: Data on safety and efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke in older patients are limited and controversial, and people aged 80 or older were under-represented in randomized trials. Our aim was to assess EVT effect for ischemic stroke patients aged ⩾80 at a nationwide level.

Patients And Methods: The cohort included stroke patients undergoing EVT from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS).

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This study explores the potential use of ChatGPT, an AI-based language model, in assessing herbal-drug interactions (HDi) to enhance clinical decision-making. HDi can pose significant health risks by reducing drug efficacy or causing unwanted side effects. Clinical pharmacists play a key role in identifying these HDIs, and currently, there are limited tools available for checking drug interactions.

L.: literature quantitative research analysis.

Purslane ( L.) has always been considered a plant with excellent qualities; in fact, it has been consumed for centuries as an edible plant but also used in folk medicine. This work aims to give an updated shot of the main features and potentialities of purslane.

Coupled Perturbed Approach to Dual Basis Sets for Molecules and Solids. II: Energy and Band Corrections for Periodic Systems.

When trying to reach convergence of quantum chemical calculations toward the complete basis set limit, crystalline solids generally prove to be more challenging than molecules. This is due both to the closer packing of atoms─hence, to linear dependencies─and to the problematic behavior of Ewald techniques used for dealing with the infinite character of Coulomb sums. Thus, a dual basis set approach is even more desirable for periodic systems than for molecules.

An ultra-short-period super-Earth with an extremely high density and an outer companion.

We present the discovery and characterization of a new multi-planetary system around the Sun-like star K2-360 (EPIC 201595106). K2-360 was first identified in K2 photometry as the host of an ultra-short-period (USP) planet candidate with a period of 0.88 d.

QCD challenges from pp to AA collisions: 4th edition.

This paper is a write-up of the ideas that were presented, developed and discussed at the fourth International Workshop on QCD Challenges from pp to AA, which took place in February 2023 in Padua, Italy. The goal of the workshop was to focus on some of the open questions in the field of high-energy heavy-ion physics and to stimulate the formulation of concrete suggestions for making progresses on both the experimental and theoretical sides. The paper gives a brief introduction to each topic and then summarizes the primary results.

Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

A discrete two time scales model of a size-structured population of parasitized trees.

The work presented a general discrete-time model of a population of trees affected by a parasite. The tree population was considered size-structured, and the parasite was represented by a single scalar variable. Parasite dynamics were assumed to act on a faster timescale than tree dynamics.

An integrative network-based approach to identify driving gene communities in chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease (COPD) is an etiologically complex disease characterized by acute exacerbations and stable phases. We aimed to identify biological functions modulated in specific COPD conditions, using whole blood samples collected in the AERIS clinical study (NCT01360398). Considered conditions were exacerbation onset, severity of airway obstruction, and presence of respiratory pathogens in sputum samples.

Synthesis of a mixed-linker Ce-UiO-67 metal-organic framework.

Ce-based metal-organic frameworks (MOFs) have recently gained scientific interest, since Ce is the most abundant rare-earth element in the Earth's crust and since their synthesis has some advantages, including first of all their redox activity, the high porosity of these crystalline materials, and Ce availability. In particular, Ce(iv)-based MOFs, such as Ce-UiO-66 and Ce-UiO-67, are synthesised under mild conditions. For most applications, the presence of functional groups in the frameworks is needed; in this context, linkers containing N-functionalities have been highlighted, as they allow for the incorporation of a large variety of metal cations.

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

Observation of Enhanced Long-Range Elliptic Anisotropies Inside High-Multiplicity Jets in pp Collisions at sqrt[s]=13 TeV.

A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

The philosophical coming of age of science. Euler's role in Cassirer's early philosophy of space and time.

Cassirer's early philosophy of space and time, overshadowed by his later work on relativity, has been scarcely explored in the literature. This paper aims to bridge this gap. It argues that understanding Cassirer's point of view requires acknowledging the pivotal role he attributed to the work of Leonhard Euler in the philosophical 'coming of age' of modern science.

Unrevealing the Damage Fingerprint on Hazelnut Metabolome by Multiomic Platforms and AI-Aided Strategies.

The brown marmorated stink bug () poses a significant threat to hazelnut crops by affecting kernel development and causing quality defects, reducing the market value. While previous studies have identified bitter-tasting compounds in affected kernels, the impact of stink bug feeding on the hazelnut metabolome, particularly concerning aroma precursors, remains underexplored. This study aims to map the nonvolatile metabolome and volatilome of hazelnut samples obtained by caging on different cultivars in two locations to identify markers for diagnosing stink bug damage.

Predicting p Values of Para-Substituted Aniline Radical Cations vs. Stable Anilinium Ions in Aqueous Media.

The focus of p calculations has primarily been on stable molecules, with limited studies comparing radical cations and stable cations. In this study, we comprehensively investigate models with implicit solvent and explicit water molecules, direct and indirect calculation approaches, as well as methods for calculating free energy, solvation energy, and quasi-harmonic oscillator approximation for para-substituted aniline radical cations (R-PhNH) and anilinium cations (R-PhNH) in the aqueous phase. Properly including and positioning explicit HO molecules in the models is important for reliable p predictions.

Inference and design of antibody specificity: From experiments to models and back.

Exquisite binding specificity is essential for many protein functions but is difficult to engineer. Many biotechnological or biomedical applications require the discrimination of very similar ligands, which poses the challenge of designing protein sequences with highly specific binding profiles. Experimental methods for generating specific binders rely on in vitro selection, which is limited in terms of library size and control over specificity profiles.