Search for the Z Boson Decay to ττμμ in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for the Z boson decay to ττμμ at the CERN LHC is presented, based on data collected by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138  fb^{-1}. The data are compatible with the predicted background. For the first time, an upper limit at the 95% confidence level of 6.

Thrombosis in myeloproliferative neoplasms: a viewpoint on its impact on myelofibrosis, mortality, and solid tumors.

This viewpoint summarizes findings from analyses of large personal patient databases of myeloproliferative neoplasms (MPNs) to assess the impact of thrombosis on mortality, disease progression, and second cancers (SC). Despite advances, the current incidence of arterial and venous thrombosis remains a challenge. These events appear to signal a more aggressive disease course, as evidenced by their association with myelofibrosis progression and mortality using multistate models and time-dependent multivariable analysis.

From Geometry of Hamiltonian Dynamics to Topology of Phase Transitions: A Review.

In this review work, we outline a conceptual path that, starting from the numerical investigation of the transition between weak chaos and strong chaos in Hamiltonian systems with many degrees of freedom, comes to highlight how, at the basis of equilibrium phase transitions, there must be major changes in the topology of submanifolds of the phase space of Hamiltonian systems that describe systems that exhibit phase transitions. In fact, the numerical investigation of Hamiltonian flows of a large number of degrees of freedom that undergo a thermodynamic phase transition has revealed peculiar dynamical signatures detected through the energy dependence of the largest Lyapunov exponent, that is, of the degree of chaoticity of the dynamics at the phase transition point. The geometrization of Hamiltonian flows in terms of geodesic flows on suitably defined Riemannian manifolds, used to explain the origin of deterministic chaos, combined with the investigation of the dynamical counterpart of phase transitions unveils peculiar geometrical changes of the mechanical manifolds in correspondence to the peculiar dynamical changes at the phase transition point.

Tear levels of apoptotic, matrix-degrading and antioxidant biomarkers in patients with and without keratoconus: A cross sectional study.

Purpose: To assess the tear levels of a set of apoptotic, matrix-degrading and antioxidant biomarkers, including Metalloproteinase 9 (MMP9), High Mobility Group Box 1 (HMGB1) and Superoxide Dismutase 3-Extracellular (SOD3).

Methods: Sandwich-ELISA commercial kits were used to test the expression of the three tear biomarkers in the lacrimal fluid of eligible participants. Linear logistic regression analysis was performed todetermine whether the set of tear biomarkers could be associated with clinically manifest keratoconus.

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

Observation of Enhanced Long-Range Elliptic Anisotropies Inside High-Multiplicity Jets in pp Collisions at sqrt[s]=13 TeV.

A search for collective effects inside jets produced in proton-proton collisions is performed via correlation measurements of charged particles using the CMS detector at the CERN LHC. The analysis uses data collected at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 138  fb^{-1}. Jets are reconstructed with the anti-k_{T} algorithm with a distance parameter of 0.

Characterizing smartphone capabilities for seismic and structural monitoring.

As seismic events continue to pose significant threats to urban infrastructure, leveraging smartphones equipped with accelerometers for real-time monitoring has gained prominence. To ascertain the reliability and sensitivity of smartphone-based measurements, an in-depth characterization of their response is essential. This article presents a thorough characterization of the performance of typical accelerometers installed on three distinct smartphone models.

Universal Defects Statistics with Strong Long-Range Interactions.

Quasi-static transformations, or slow quenches, of many-body quantum systems across quantum critical points generate topological defects. The Kibble-Zurek mechanism regulates the appearance of defects in a local quantum system through a classical combinatorial process. However, long-range interactions disrupt the conventional Kibble-Zurek scaling and lead to a density of defects that is independent of the rate of the transformation.

and , in addition to , may cause Phomopsis cane and leaf spot disease in grapevine.

Phomopsis cane and leaf spot (PCLS) disease, affecting grapevines ( and spp.), has been historically associated with . Typical disease symptoms, comprising bleaching and black pycnidia, have also been associated with other spp.

Liquid-Liquid Transition in a Bose Fluid near Collapse.

Discovering novel emergent behavior in quantum many-body systems is a main objective of contemporary research. In this Letter, we explore the effects on phases and phase transitions of the proximity to a Ruelle-Fisher instability, marking the transition to a collapsed state. To accomplish this, we study by quantum Monte Carlo simulations a two-dimensional system of soft-core bosons interacting through an isotropic finite-ranged attraction, with a parameter η describing its strength.

Measurement of Energy Correlators inside Jets and Determination of the Strong Coupling α_{S}(m_{Z}).

Energy correlators that describe energy-weighted distances between two or three particles in a hadronic jet are measured using an event sample of sqrt[s]=13  TeV proton-proton collisions collected by the CMS experiment and corresponding to an integrated luminosity of 36.3  fb^{-1}. The measured distributions are consistent with the trends in the simulation that reveal two key features of the strong interaction: confinement and asymptotic freedom.

Energetics and quantumness of Fano coherence generation.

In a multi-level quantum system Fano coherences stand for the formation of quantum coherences due to the interaction with the continuum of modes characterizing an incoherent process. In this paper we propose a V-type three-level quantum system on which we certify the presence of genuinely quantum traits underlying the generation of Fano coherences. We do this by determining work conditions that allows for the loss of positivity of the Kirkwood-Dirac quasiprobability distribution of the stochastic energy changes within the discrete system.

The use of reduced DOAC doses in atrial fibrillation patients does not always lead to good anticoagulation levels and avoid adverse events.

Background: The MAS study (Blood Advances 2024) showed that a high proportion of Italian AF patients treated with direct oral anticoagulants (DOACs) receive reduced doses. This sub-analysis of MAS data aimed to analyze the effects of reduced (appropriate or not)- or standard-dose use on DOAC activity assessed at baseline and the occurrence of thrombotic or bleeding complications during follow-up.

Methods: The MAS study design, the methods for DOAC measurement, the results, and the adverse events during follow-up, are described in detail elsewhere.

Measurement of multijet azimuthal correlations and determination of the strong coupling in proton-proton collisions at .

A measurement is presented of a ratio observable that provides a measure of the azimuthal correlations among jets with large transverse momentum . This observable is measured in multijet events over the range of - based on data collected by the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 , corresponding to an integrated luminosity of 134 . The results are compared with predictions from Monte Carlo parton-shower event generator simulations, as well as with fixed-order perturbative quantum chromodynamics (pQCD) predictions at next-to-leading-order (NLO) accuracy obtained with different parton distribution functions (PDFs) and corrected for nonperturbative and electroweak effects.

Improving hidradenitis suppurativa management: consensus statements from physicians and patients' perspectives.

Hidradenitis suppurativa (HS) is a frequent chronic inflammatory skin condition primarily affecting areas rich in apocrine sweat glands, presenting with comedones, papules, nodules, and abscesses, as well as tunnels and hypertrophic scarring. Despite its prevalence and impact on quality of life, the pathogenesis of HS remains incompletely understood. Notably, its diagnosis often suffers from delays and misidentification, therefore an improved education for healthcare providers is mandatory.

Entrance channels to coproheme in coproporphyrin ferrochelatase probed by exogenous imidazole binding.

Iron insertion into porphyrins is an essential step in heme biosynthesis. In the coproporphyrin-dependent pathway, specific to monoderm bacteria, this reaction is catalyzed by the monomeric enzyme coproporphyrin ferrochelatase. In addition to the mechanistic details of the metalation of the porphyrin, the identification of the substrate access channel for ferrous iron to the active site is important to fully understand this enzymatic system.

Constraints on anomalous Higgs boson couplings from its production and decay using the WW channel in proton-proton collisions at .

A study of the anomalous couplings of the Higgs boson to vector bosons, including -violation effects, has been conducted using its production and decay in the WW channel. This analysis is performed on proton-proton collision data collected with the CMS detector at the CERN LHC during 2016-2018 at a center-of-mass energy of 13 TeV, and corresponds to an integrated luminosity of 138 . The different-flavor dilepton final state is analyzed, with dedicated categories targeting gluon fusion, electroweak vector boson fusion, and associated production with a W or Z boson.